Recent content by Feelsbadman.jpg

Something else I was curious about was the affinity that 5AR1 has for T and P. Since men have higher T than women, I thought P would have to compete with T for 5AR availability more so in men than women. I managed to find this: https://jme.bioscientifica.com/view/journals/jme/36/2/0360239.xml...

This is from the other thread. ------------------------------------------------------------------------------------------------------------------------------------------------------------ To expand on the above, the increase in allopregnanolone levels during the luteal phase of the menstrual...

More evidence Dutasteride does not produce any form of cognitive/neurological impairment. https://link.springer.com/article/10.1007/s40261-018-0720-7 Evidence to support the claim that allopregnanolone can have detrimental cognitive effects. It is a stress hormone, like I have been saying...

I am not looking to feed this troll but just to clarify this misinformation being pushed to others who may read this thread: This study uses Finasteride which does not inhibit 5 Alpha Reductase type 1 to any significant degree. 5AR type 1 is the primary type of 5AR in the brain. This is common...

You weren't even capable, and still aren't, of understanding the argument. Your mind can only process lower allopregnanolone = bad. The one comment you're referring to in the HMI-115 thread is an objective correction of basic logic syntax that reiterates my point you have no business commenting...

The hair quality definitely looks worse and it looks like you receded but the angles are different. Here is my best guess/hypothesis as to what happened to you, assuming your dutasteride was legitimate: You nuked your estrogen receptor beta stimulation in your hair follicles. Due to low levels...

Don't you mean understatement? Overstatement implies that highly unlikely is an exaggeration. Understatement would mean that Pegasus is "under" estimating the improbability of his claim.

None that don't require 5 alpha reductase from I've seen. Even the so called "back door" pathway still uses 5AR. This is what confuses me about the 40% reduction. I suppose the giga prostates are just pumping enormous amounts of 5AR and DHEA is being converted to T to provide ample substrate in...

You're not able to follow a logical argument. I had to explain to you what a limit is and how it applies to steady state drug levels. You are obsessed with the notion that any reduction in allopregnanolone is bad when the truth is far more nuanced (actual levels don't matter so much as...

dutasteride has been shown to be neuroprotective. I had brain fog on finasteride. On dutasteride, I have a very clear mind, possibly better than before any 5AR. This is anecdotal, but there is another thread in this section where I explain why I think the whole allopregnanolone/brain fog hype with dutasteride is way...

T increased roughly the same amount as in other studies. The real concern is the lack of DHT inhibition. Only about 40%. The authors state that it was due to increased DHEA conversion to T then to DHT but I don't understand how as this still requires 5AR. They did this study on men with very...

Thanks

https://journals.sagepub.com/doi/abs/10.1177/2051415820926301 Does anyone have access to the full study and mind sharing?

This. Also it looks like at least one of the compounds would suitable for transdermal delivery as avg mass is < 500 da. http://www.chemspider.com/Chemical-Structure.426351.html benzo[d]imidazo[2,1-b]thiazole Molecular FormulaC9H6N2S Average mass174.222 Da Monoisotopic mass174.025162 Da...

https://www.amazon.com/Harmine-Harmaline-HCL-1-GR/dp/B08PQBC1H6 Looks to be easily procured and cheap.