Recent content by Canuto

Parati dude.

Raise your topical dose and you will still accomplish your goal with no extra burden on the liver, even if you will achieve the same 5-ar suicidal inhibition throughout the whole body. There's a point in which more drug won't lead to a higher 5-ar inhibition anyway.

Delivery it's not hard at all. The 500 Dalton rule has always been misinterpreted. We have data showing that it lowers s app DHT even when dissolved in Trichosol, with no penetration enhancer. So if you get liposomes you will have a really good amount of local DHT inhibition, with reduced...

I've explained it several times why it's pointless to use both and why topical is superior. With topical duta, I would personally use a topical AA, but you can start with it in monotherapy amd see how it goes.

CB won't affect none of the 2 if it's genuine CB, so, with metabolite being a corticosteroid, the only necessary thing to check is adrenal function. The rest is optional.

Can you post your latest blood work again? I recall seeing it in the past and you had hypothyroidism and you were anaemic. No surprise 5-ar inhibitors and anti-androgens are not doing anything to you. You probably don't even have Androgenetic Alopecia.

It depends where you live.

Try CB, but get a baseline ACTH, cortisol and DHEA-S levels and retest after 2 weeks to see if they got affected.

Ha! To make it simple, when you introduce an exogenous hormone in the body and your body senses it (through the receptors) it will shutdown the correspondent pathway. So in the case of CB0301, if cortexolone (a corticosteroid and metabolite of clascoterone) gets too high in the bloodstream and...

It could work, but if there's no 5-ar (or little left) you're still inhibiting the first pathway, which is progesterone to DHP, so that won't lead to any allopregnanolone synthesis.

Alone won't do much I think, but you know the bro-science on the internet is hard to die. You still have people swallowing oral 5-ar inhibitors to target a single tissue.

They will need to clarify that in phase III obviously. To be an HPA suppressant, it should work the same way as as Dexamethasone when used to diagnose the Cushing's syndrome. It's a glucocorticoid that binds to the corticosteroids receptors in the hypothalamus, which in turn signal the...

Dismiss whatever you read on that forum. Progesterone works binding to 5-ar to get 5-a reduced to DHP and then to allopregnanolone though 3α-HSD. So, differently from finasteride, it will actually have a calming and cognitive enhancement function. If it gets too high in the bloodstream though...

Keep your lifestyle choices the same, even if they are poor. Get a baseline blood test within 1 or 2 hours after awakening in the morning. Repeat blood test the day after the application and 7 days before application, on the day you're supposed to apply it again (if you're doing once weekly...

Next one is my hedgehog. But I'm concerned his spikes won't get as hard and straight as before due to side effects.