i was just wondering why is nizoral shampoo in the big 3 with minoxidil and propecia. i havent read of any cases where ppl have had success with nizoral on its own? but i did read of ppl having success with other products not in the top 3 on their own, like revivogen. so whats good about nizoral? any ideas.
why is nizoral in the big 3
- Thread starter jimjohn
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The Gardener
Senior Member
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Two reasons.
Nizoral annihilates the Malaseezia yeast that is naturally occurring on human scalps. This yeast, although an endemic human parasite, is irritative to humans and is a known causative factor for seborrheic dermatitis and dandruff. It's presence stimulates an immune response from the skin that is similar in nature to the immune response that DHT causes when attacking follicle cells, and both stimuli together have a synergistic effect on the scalp, accelerating the male pattern baldness process.
Second, Nizoral is a mild anti-androgen, I believe there is a clinical study giving it regrowth properties comparable in scale to 2% minoxidil.[/code]
Nizoral annihilates the Malaseezia yeast that is naturally occurring on human scalps. This yeast, although an endemic human parasite, is irritative to humans and is a known causative factor for seborrheic dermatitis and dandruff. It's presence stimulates an immune response from the skin that is similar in nature to the immune response that DHT causes when attacking follicle cells, and both stimuli together have a synergistic effect on the scalp, accelerating the male pattern baldness process.
Second, Nizoral is a mild anti-androgen, I believe there is a clinical study giving it regrowth properties comparable in scale to 2% minoxidil.[/code]
"Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia", Piérard-Franchimont et al, Dermatology 1998;196:474-477.
"...Left untreated, androgen-dependent alopecia progressively deteriorates. This was found in the Androgenetic Alopecia subgroup using the nonmedicated shampoo alone. In contrast, both present studies concur to show an unequivocable effect of a 2% KCZ shampoo on hair variables affected by Androgenetic Alopecia. Hair density and size, and proportion of anagen follicles were all improved. Although the number of subjects was limited in the second study, results obtained compare with minoxidil. It has been stated that medications capable of maintaining the existing hair population should be regarded as effective treatments for Androgenetic Alopecia. The present data suggest that KCZ should enter this group of drugs".
"Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men".
Hugo Perez BS.
California College of Podiatric Medicine, 371 Columbus Avenue, 94133, San Francisco, CA, USA
Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (Androgenetic Alopecia). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat Androgenetic Alopecia. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of Androgenetic Alopecia. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat Androgenetic Alopecia.
PMID: 14729013 [PubMed - as supplied by publisher]
"...Left untreated, androgen-dependent alopecia progressively deteriorates. This was found in the Androgenetic Alopecia subgroup using the nonmedicated shampoo alone. In contrast, both present studies concur to show an unequivocable effect of a 2% KCZ shampoo on hair variables affected by Androgenetic Alopecia. Hair density and size, and proportion of anagen follicles were all improved. Although the number of subjects was limited in the second study, results obtained compare with minoxidil. It has been stated that medications capable of maintaining the existing hair population should be regarded as effective treatments for Androgenetic Alopecia. The present data suggest that KCZ should enter this group of drugs".
"Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men".
Hugo Perez BS.
California College of Podiatric Medicine, 371 Columbus Avenue, 94133, San Francisco, CA, USA
Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (Androgenetic Alopecia). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat Androgenetic Alopecia. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of Androgenetic Alopecia. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat Androgenetic Alopecia.
PMID: 14729013 [PubMed - as supplied by publisher]
global said:
Hair Loss Study Abstract: Ketoconazole binds to the human androgen receptor.
Title
Ketoconazole binds to the human androgen receptor.
Author
Eil C
Address
Department of Internal Medicine, Naval Hospital, Bethesda, Maryland.
Source
Horm Metab Res, 24: 8, 1992 Aug, 367-70
Abstract
Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections. Based on these potent effects on gonadal function in vivo as well as previous work in vitro demonstrating affinity of ketoconazole for receptor proteins for glucocorticoids and 1,25(OH)2 vitamin D3 and for sex steroid binding globulin (SSBG), the binding of ketoconazole to human androgen receptors (AR) in vitro was also examined. Ketoconazole competition with [3H]methyltrienolone (R1881) for androgen binding sites in dispersed, intact cultured human skin fibroblasts was determined at 22 degrees C. Fifty percent displacement of [3H]R1881 binding to AR was achieved by 6.4 +/- 1.8 (SE) x 10(-5) M ketoconazole. Additional binding studies performed with ketoconazole in the presence of increasing amounts of [3H]R1881 showed that the interaction of ketoconazole with AR was competitive when the data were analyzed by the Scatchard method. It should be noted, however, that the dose of ketoconazole required for 50% occupancy of the androgen receptor is not likely to be achieved in vivo, at least in plasma. Finally, androgen binding studies performed with other imidazoles, such as clotrimazole, miconazole, and fluconozole, revealed that in this class of compounds only ketoconazole appears to interact with the androgen receptor. Ketoconazole appears to be the first example of a non-steroidal compound which binds competitively to both SSBG and multiple steroid hormone receptors, suggesting that the ligand binding sites of these proteins share some features in common.
Language of Publication
English
Unique Identifier
92406209
Hi everyone,
I read a lot about Ketoconazole. I know what is is said to do. However, waht I dont' understand is how the hell it works when is used in a shampoo??? 5 minutes aren't enough to let anything to penatrate through the scalp...let alone reach the follicles....Even ethanlo, which is know to penatrate need atound 15 to 20 minutes....Can anyone explain to me how the hell shampoos help?? Regular antidandruff shampoos work because the affect the upper layers of the dermis of the scalp...exfoliate or take off exess flakings. But the deffinately can't attach to anything underneath the skin or hair follicles. Not in 5 minutes at the most. And even after these 5minutes they are rinsed....
I read a lot about Ketoconazole. I know what is is said to do. However, waht I dont' understand is how the hell it works when is used in a shampoo??? 5 minutes aren't enough to let anything to penatrate through the scalp...let alone reach the follicles....Even ethanlo, which is know to penatrate need atound 15 to 20 minutes....Can anyone explain to me how the hell shampoos help?? Regular antidandruff shampoos work because the affect the upper layers of the dermis of the scalp...exfoliate or take off exess flakings. But the deffinately can't attach to anything underneath the skin or hair follicles. Not in 5 minutes at the most. And even after these 5minutes they are rinsed....
Petchsky
Senior Member
- Reaction score
- 13
eliazush said:
I don't know the science behind it but it does something that helps. Either that or we are all squirting expensive pink shampoo on to our palms for nothing.
People have found using Nizoral helps with the immune response male pattern baldness triggers and creates a healthier environment for the hair.
I had this problem and it was not in till i got the dermatitis under control that proscar started to work.
Nizoral is not for everyone though, some people find that doesn't really help or irritates an already irritated scalp...
I had SD and i use nizoral . I put it on when i first get my hair wet, and leave it in for the duration of the shower whether i shave or wash whatever...usually its probably on my scalp for 10minutes or so.
Emphasis on i HAD SD...nizoral cleared it up completely
Emphasis on i HAD SD...nizoral cleared it up completely
Britannia
Senior Member
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- 3
Its cheap. It apparantly has results comparible to 2% Minoxidil. Its clean and easy to use. Even if it doesnt help your male pattern baldness, it will leave your hair squeaky clean and your scalp healthy. Oh and it can be used in conjuction with finasteride + MIn with no problems.
I think Nizoral quite rightly has a place in the big 3.
All hail Nizoral.
I think Nizoral quite rightly has a place in the big 3.
All hail Nizoral.
