Personally, and it's just a bro-science theory, I don't think DHT has anything to do with it.
I believe brown adipose tissue degradation is 100% responsible for it, and DHT, up-regulation of androgen receptors, and every other protein they are looking at are dead ends.
Here's my bro-science theory:
As BAT tissue degrades, the hair follicles become inflamed somehow. In response to this inflammation, the HF up-regulates androgen receptors to bind more anti-inflammatory DHT, which does not help.
BAT usually degrades in the male pattern baldness zone, NOT on the sides and back of the head. This would explain why:
-HF's on the sides and back of the head are not effected by DHT whatsoever.
-DHT does not have a negative effect on HF's anywhere else on the body.
Perhaps 5AR inhibitors, and the small estrogen increase stop the degradation of BAT and put a "pause" on the cascade?
All that being said, we know for sure:
-Nuking DHT to 0 does not reverse male pattern baldness
-Transition drugs (Bica, estrogen, etc etc) can and often do "reverse" male pattern baldness, with the unfortunate side effect of turning one into a woman.
-Minoxidil works, but its laughable at best.
Idk, just rambling. Wish I knew of a way to increase BAT activity in the scalp, I'd almost bet it would reverse the whole cascade.