Why Are Some Men Horribly Affected By Finasteride?

[jimmyjonas]

Has anything regrowth or thickened up?

It sounds like your dht never came back

No I wouldn't say I've had regrowth just stopped it's like I'm not shedding, I went to an endo and he tested me for bloods said all I was in range but test was low but not in my boots low his words, it was like 15 on a range from 7 - 30 I think, I got a second blood test done a few weeks after this and test had gone up to 19 if that means anything I don't know being honest that was around December, I spent a lot of cash on doctors and just drew the line and said f*** it if I keep going like this I will be in financial ruin plus I found Swole Source and made the decision this is the way to go, I could keep spending a fortune on docs and still have no answers because there are none it's just a case of living clean and putting your body in the best state to rebalance that's the way I've decided to go and it's helped me more than doctors have.

 

[tommyt123]

it's seems more likely now that the catastrophic side effects that some get are a result of reducing 5 alpha reductase activity in the brain which subsequently effect the levels of allopregnanolone and other neurosteroids which are important for brain fucntion and are involved in mood regulation etc. For a reason that is not clear yet neurosteroid levels are not able to return to normal levels in some people and this results in some of the depressive and sexually related symtoms of PFS. A recent harvard study found that PFS patients likely have normal peripheral androgen senstivity and seem to have relatively normal hormonal profiles, it's most likely that their brain chemistry has been altered in such a way that they have chronic mood and sexual dysfunction. Just remember that all erections start with the brain!! I belive that this side effect is extremely rare and that some people are susceptible to epigenetic changes (upon chronic 5 alpha reductase inhibition) that lead to the symptoms associated with PFS. Although it's quite astounding that even such small durations of 5alpha-reductase inhibition can lead to permanent changes.

 

[jimmyjonas]

it's seems more likely now that the catastrophic side effects that some get are a result of reducing 5 alpha reductase activity in the brain which subsequently effect the levels of allopregnanolone and other neurosteroids which are important for brain fucntion and are involved in mood regulation etc. For a reason that is not clear yet neurosteroid levels are not able to return to normal levels in some people and this results in some of the depressive and sexually related symtoms of PFS. A recent harvard study found that PFS patients likely have normal peripheral androgen senstivity and seem to have relatively normal hormonal profiles, it's most likely that their brain chemistry has been altered in such a way that they have chronic mood and sexual dysfunction. Just remember that all erections start with the brain!! I belive that this side effect is extremely rare and that some people are susceptible to epigenetic changes (upon chronic 5 alpha reductase inhibition) that lead to the symptoms associated with PFS. Although it's quite astounding that even such small durations of 5alpha-reductase inhibition can lead to permanent changes.

I'm not convinced of that to be honest, if its effects were that powerful a lot more than 1.4 % would be having issues in my opinion, could be wrong, Also persistent would be a better word to describe it, many have recovered, I've read a lot of recoveries they just don't get as much coverage.

 

[tommyt123]

I'm not convinced of that to be honest, if its effects were that powerful a lot more than 1.4 % would be having issues in my opinion, could be wrong, Also persistent would be a better word to describe it, many have recovered, I've read a lot of recoveries they just don't get as much coverage.

yeah agreed it's barley understood and most of what i'm saying is just conjecture, but i just think it's likely that the issue is much more than due to just suppression of DHT as the 2 iso enzymes inhibited by finasteride are involved in processes that go beyond production of DHT.

 

[g.i joey]

yeah agreed it's barley understood and most of what i'm saying is just conjecture, but i just think it's likely that the issue is much more than due to just suppression of DHT as the 2 iso enzymes inhibited by finasteride are involved in processes that go beyond production of DHT.

But that's the thing, numerous studies show that 5ar2 doesn't play much of a role in the brain and isn't really found there at all. But I've also read that 5ar3 is inhibitted on finasteride, never really got the run down on what blocking 5ar3 can cause though.

 

[dralex]

THAT my friend is the question EVERYONE asks themselves. If there were a way to establish who would get sides and who wouldnt, there wouldn't be such a sh*t show about finasteride.

I really wish we understood why some people respond so well to finasteride while others don't as well. It is clear that finasteride works better when you catch your hair loss earlier on, but that isn't the case for everyone. Some people can get insane regrowth and go from a NW3 to a NW2 on finasteride alone, and some people seem to lose hair faster than before they went on it. Hair loss is too fuckn complicated.

 

[tommyt123]

re

But that's the thing, numerous studies show that 5ar2 doesn't play much of a role in the brain and isn't really found there at all. But I've also read that 5ar3 is inhibitted on finasteride, never really got the run down on what blocking 5ar3 can cause though.

really? i was under the impression that 5ar2 was expressed in the brain but just not to the same extent as 5ar1. Could you link me to that study? I also got to delve more into the function 5ar3.

i wish i wasn't this pedantic and could just take the pills and forget about it lol.

 

[g.i joey]

re

really? i was under the impression that 5ar2 was expressed in the brain but just not to the same extent as 5ar1. Could you link me to that study? I also got to delve more into the function 5ar3.

i wish i wasn't this pedantic and could just take the pills and forget about it lol.

This is what I found on Wikipedia a couple weeks ago when reading on 5ar, Its consistent with what I've seen some forum members write

"Scientists looked for 5α-R2 expression in fetal liver, adrenal, testis, ovary, brain, scalp, chest, and genital skin, using immunoblotting, and were only able to find it in genital skin.[8]"

 

[tommyt123]

This is what I found on Wikipedia a couple weeks ago when reading on 5ar, Its consistent with what I've seen some forum members write

"Scientists looked for 5α-R2 expression in fetal liver, adrenal, testis, ovary, brain, scalp, chest, and genital skin, using immunoblotting, and were only able to find it in genital skin.[8]"

yeah they're talking about expression of 5aR2 expression in the fetus not in a grown man. i'm pretty sure it's expressed in the brain in adults i'll find a reference when i have time.

edit

yep if you read further into the paper "5α-R1-3 is ubiquitously expressed [10, 11, 13, 20, 55]. 5α-R1 and 5α-R2 are expressed differently in liver, genital and nongenital skin, prostate, epididymis, seminal vesicle, testis, ovary, uterus, kidney, exocrine pancreas, and brain (Table 2, Aumuller et al.)." they are talking about adults in that quote.

 

[tommyt123]

The most positive indication i can say about 5aR2 inhibition is that psudeohemaphrodites that lack this enzyme seem to be perfectly healthy although barley anything is known about 5aR3