Who is to Blame - The Follicle or the DHT?

[mbehr22]

How does it all work ... when male pattern baldness begins, is there a sudden change in the makeup/receptors in your follicles, or is the production/type of DHT produced increase/change ...

im trying to learn more about this process...

when I was 15, even 20 or 25, hairloss never even occured to me to be a possibility. Now im beginning to thin all over the top, so who is to blame? What has changed inside of me?

 

[Guest]

hm, i dont know, i only know that it is good to protect the follicle from dht by an anti-androgen and to reduce dht by a dht-blocker. and its good to get more blood in your scalp, by something like minoxidil.

 

[Bryan]

How does it all work ... when male pattern baldness begins, is there a sudden change in the makeup/receptors in your follicles, or is the production/type of DHT produced increase/change ...

Neither one, actually. The response of your hair follicles to androgens begins a change for the worse.

 

[mbehr22]

How does it all work ... when male pattern baldness begins, is there a sudden change in the makeup/receptors in your follicles, or is the production/type of DHT produced increase/change ...

Neither one, actually. The response of your hair follicles to androgens begins a change for the worse.

can you elaborate ...

 

[Bryan]

A much-discussed study with stumptailed macaques found that prior to puberty, their scalp hair follicles don't seem to be affected by androgens. In other words, they have a neutral response. It's apparently sometime during or after puberty that the response starts to change, and the growth of their scalp hair follicles starts to be suppressed by androgens. Nobody knows why it changes that way.

Human scalp hair follicles probably act the same way.

 

[barcafan]

hairloss has got to be studied more..... Imagine how much money the 'cure' would make.....

 

[s.a.f]

I'm sure there are companies working to find that cure as we speak but altering genetics is a huge task.

 

[antonio666]

to s.a.f
it's not altering genetics

we have to block genetics

 

[s.a.f]

Well thats also not easily done. (at least safely)

 

[antonio666]

but in theory if you took 2.5mg of avodart daily you would be surpressing 100% dht,is that not a cure,because if it is then the drug componies
should sell it has 2.5mg more cheaply than they do today and let the individual take the risks

 

[s.a.f]

dutasteride and finasteride are not m.p.b cures they are simply DHT inhibitors they are not guarateed to regrow hair or even halt hairloss.

 

[powersam]

a multi pronged treatment approach is going to help better in my opinion.

something to inhibit 5 alpha reductase

something to block dht from binding with androgen receptor

something to cut down inflammation

something to halt, reverse fibrosis

etc.

 

[abcdefg]

Yeah it never really made sense to me. If you took enough dutasteride and started at the very first sign of hairloss the you shouldnt lose any hair and keep your hair for life. That doesnt always happen so whats wrong?

Someone needs to have some men start dutasteride at the very first signs of hairloss and track how much hair they lose. In theory they should keep all there hair for life.

 

[s.a.f]

Not everyone responds to treatment. Who knows why?

 

[abcdefg]

yeah why do some men not respond to propecia if dht is the reason we lose hair?
What if the men that claim propecia made there hair worse are right?