freudling
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OK, Revivogen, Revivogen and, well spironolactone in conjunction with Revivogen. Could this be Propecia's replacement? I suspect not, but you be the judge so far.
How Revivogen and spironolactone work:
Both are said to inhibit DHT and occupy androgen receptors.
Revivogen:
Out of 39 Participants, 30 (77%) have reported experiencing positive results including decreased hair loss and increased thickness of the hair. 9 users (23%) have reported no benefits. You can review the individual assessments to draw your own conclusions. Will NOT increase thickness of miniturized follicles.
The active ingredients of Revivogen® are natural compounds proven to inhibit 5-Alpha-Reductase (the enzyme that produces DHT), block the androgen receptors and stimulate hair growth. These active ingredients include Gamma Linolenic acid (GLA), Alpha Linolenic acid (ALA), Linoleic Acid, Oleic Acid, Azaleic acid, Vitamin B6, Zinc, Saw Palmetto Extract, Beta-Sitosterol and Procyanidin Oligomers.
What BLOCKS the androgen receptors? Saw Palmetto (also inhibits 5-Alpha-Reductase). The rest help block formation of DHT, except:
Procyanidin Oligomers there to stimulate growth similar to minoxidil.
spironolactone:
Inhibits 5-Alpha-Reductase and competes with DHT by occupying receptor sites as well.
One Case Study available showing perhaps favorable male pattern baldness effects:
Acta Derm Venereol 1990;70(4):342-343
Reversal of andro-genetic alopecia in a male. A spironolactone effect?
Bou-Abboud CF, Nemec F, Toffel F
Department of Internal Medicine, University Medical Center of Southern Nevada, University of Nevada School of Medicine.
This 73-year-old white male has been bald since the age of 28. He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years. For the last 3 months, his hair had started to regrow over the scalp. This might be related to the antiandrogenic effect of spironolactone.
spironolactone caused Hepatitus?
Spironolactone-induced hepatitis. Thai KE, Sinclair RD.
Department of Medicine (Dermatology), The University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.
PMID: 11488711 [PubMed - indexed for MEDLINE]
spironolactone causes tumors?
In rats, spironolactone has been found to increase the risk of tumors. It is not known if spironolactone increases the chance of tumors in humans.
http://www.anagen.net/spiroin.htm
Lastly, spironolactone suggested for use in women with Androgenetic Alopecia.
1: J Eur Acad Dermatol Venereol. 1999 May;12(3):205-14. Management of androgenetic alopecia. Tosti A, Camacho-Martinez F, Dawber R. Department of Dermatology, University of Bologna, Italy. tosti@almadns.unibo.it PMID: 10461639 [PubMed - indexed for MEDLINE]
spironolactone being suggested for use in Women for Androgenetic Alopecia is definately a trend in the literature.
Besides Lee's site, I am having trouble finding literature on topical spironolactone and male pattern baldness. Anybody know of any let me know.
So, I have NOT found any HARD data regarding spironolactone and male pattern baldness. Found some for Revivogen, but that was the companies study and the data are a little vague (reports of users @ 77% + rate). How does Propecia fair. From one of the original studies:
Oral finasteride at the dosage of 1 mg/day produced clinical improvement in up to 66% of patients treated for 2 years. The drug is effective for both frontal and vertex hair thinning.
Another study concluded:
: Dermatology. 2004;209(2):117-25. Related Articles, Links Click here to read An open, randomized, comparative study of oral finasteride and 5% topical minoxidil in male androgenetic alopecia.
Arca E, Acikgoz G, Tastan HB, Kose O, Kurumlu Z.
Department of Dermatology, Gulhane Military Medical Academy, School of Medicine, Etlik-Ankara, Turkey. earca@gata.edu.tr
In the clinical evaluation at the endpoint of treatment, the clinical cure rates (i.e. increased intensity of hair) were 80% (32/40) for the oral finasteride group and 52% (13/25) for the 5% topical minoxidil group.
Well, what is CERTAIN is the research on minoxidil and Propecia are far less vague than that of Revivogen or spironolactone. In fact, from what I have dug up so far, the research on the latter two treatments is far from anything resembling decisive conclusions. By all means, anybody have some studies that tell us more about Revivogen and spironolactone?
My recommendation is to sit back and watch what happens with these substances. I have read some good and bad things about both Revivogen and spironolactone. The question is are they more effective when taken without Propecia than Propecia alone? I suspect not, but taken in conjunction with Propecia could help, theoretically.
How Revivogen and spironolactone work:
Both are said to inhibit DHT and occupy androgen receptors.
Revivogen:
Out of 39 Participants, 30 (77%) have reported experiencing positive results including decreased hair loss and increased thickness of the hair. 9 users (23%) have reported no benefits. You can review the individual assessments to draw your own conclusions. Will NOT increase thickness of miniturized follicles.
The active ingredients of Revivogen® are natural compounds proven to inhibit 5-Alpha-Reductase (the enzyme that produces DHT), block the androgen receptors and stimulate hair growth. These active ingredients include Gamma Linolenic acid (GLA), Alpha Linolenic acid (ALA), Linoleic Acid, Oleic Acid, Azaleic acid, Vitamin B6, Zinc, Saw Palmetto Extract, Beta-Sitosterol and Procyanidin Oligomers.
What BLOCKS the androgen receptors? Saw Palmetto (also inhibits 5-Alpha-Reductase). The rest help block formation of DHT, except:
Procyanidin Oligomers there to stimulate growth similar to minoxidil.
spironolactone:
Inhibits 5-Alpha-Reductase and competes with DHT by occupying receptor sites as well.
One Case Study available showing perhaps favorable male pattern baldness effects:
Acta Derm Venereol 1990;70(4):342-343
Reversal of andro-genetic alopecia in a male. A spironolactone effect?
Bou-Abboud CF, Nemec F, Toffel F
Department of Internal Medicine, University Medical Center of Southern Nevada, University of Nevada School of Medicine.
This 73-year-old white male has been bald since the age of 28. He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years. For the last 3 months, his hair had started to regrow over the scalp. This might be related to the antiandrogenic effect of spironolactone.
spironolactone caused Hepatitus?
Spironolactone-induced hepatitis. Thai KE, Sinclair RD.
Department of Medicine (Dermatology), The University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.
PMID: 11488711 [PubMed - indexed for MEDLINE]
spironolactone causes tumors?
In rats, spironolactone has been found to increase the risk of tumors. It is not known if spironolactone increases the chance of tumors in humans.
http://www.anagen.net/spiroin.htm
Lastly, spironolactone suggested for use in women with Androgenetic Alopecia.
1: J Eur Acad Dermatol Venereol. 1999 May;12(3):205-14. Management of androgenetic alopecia. Tosti A, Camacho-Martinez F, Dawber R. Department of Dermatology, University of Bologna, Italy. tosti@almadns.unibo.it PMID: 10461639 [PubMed - indexed for MEDLINE]
spironolactone being suggested for use in Women for Androgenetic Alopecia is definately a trend in the literature.
Besides Lee's site, I am having trouble finding literature on topical spironolactone and male pattern baldness. Anybody know of any let me know.
So, I have NOT found any HARD data regarding spironolactone and male pattern baldness. Found some for Revivogen, but that was the companies study and the data are a little vague (reports of users @ 77% + rate). How does Propecia fair. From one of the original studies:
Oral finasteride at the dosage of 1 mg/day produced clinical improvement in up to 66% of patients treated for 2 years. The drug is effective for both frontal and vertex hair thinning.
Another study concluded:
: Dermatology. 2004;209(2):117-25. Related Articles, Links Click here to read An open, randomized, comparative study of oral finasteride and 5% topical minoxidil in male androgenetic alopecia.
Arca E, Acikgoz G, Tastan HB, Kose O, Kurumlu Z.
Department of Dermatology, Gulhane Military Medical Academy, School of Medicine, Etlik-Ankara, Turkey. earca@gata.edu.tr
In the clinical evaluation at the endpoint of treatment, the clinical cure rates (i.e. increased intensity of hair) were 80% (32/40) for the oral finasteride group and 52% (13/25) for the 5% topical minoxidil group.
Well, what is CERTAIN is the research on minoxidil and Propecia are far less vague than that of Revivogen or spironolactone. In fact, from what I have dug up so far, the research on the latter two treatments is far from anything resembling decisive conclusions. By all means, anybody have some studies that tell us more about Revivogen and spironolactone?
My recommendation is to sit back and watch what happens with these substances. I have read some good and bad things about both Revivogen and spironolactone. The question is are they more effective when taken without Propecia than Propecia alone? I suspect not, but taken in conjunction with Propecia could help, theoretically.