Whatever happened to the Pgd2 inhibitor bandwagon?

[dan1938]

even the google results are sparse.

 

[peacemaker]

AFAIK some people had bad reactions to it, some people said that they didn't work and some people said that it completely halted their hair loss in a few days. They are kind of risky though because they are hard to obtain and you have to know the amount to apply and we don't have a lot of info on their safety profiles. In short, you can try them yourself and see : ). Don't expect regrowth from them tho.

 

[bushbush]

Read this recent publication: http://www.docdroid.net/9jqw/exd12348.pdf.html

Research on PGD2 continues.

 

[maher]

Read this recent publication: http://www.docdroid.net/9jqw/exd12348.pdf.html

Research on PGD2 continues.

"Any items found to be elevated in bald scalp might be a product of that state rather than a cause of it." Interesting- i was saying that all along and you guys gave me neg.rep. every time i mentioned it.They are still sceptic.

 

[bushbush]

"Any items found to be elevated in bald scalp might be a product of that state rather than a cause of it." Interesting- i was saying that all along and you guys gave me neg.rep. every time i mentioned it.They are still sceptic.

Please read the very next line. A causal relationship has been demonstrated experimentally. It is not just a correlation.

Therefore it was important to demonstrate that PGD2 indeed did decrease hair lengthening in both man and mouse. Therefore, we tested the effect on PGD2 on mouse models with inactivating mutations in each of the receptors for PGD2 --- PTGDR (DP-1) or GPR44 (DP-2). While PTGDR was not required for PGD2 to inhibit hair growth, GPR44 was required. Recent work from our group has shown that just as PGD2 and GPR44 inhibit hair growth, they also inhibit hair follicle regeneration after wounding(36).

 

[maher]

Please read the very next line. A causal relationship has been demonstrated experimentally. It is not just a correlation.

Wake up dude! interfering in immune system response changes nothing. dealing with pgd2 does't influence on pathophysiological changed tissue on scalp. Of course they are optimistic, they are on a good way to manipulate data and to create the "revolutionary cure" for baldness. forget it! In my opinion thats a step back in comparison to 5ar inhibitors. They are just working on a new angle to sell more ****.

 

[bushbush]

Of course they are optimistic, they are on a good way to manipulate data and to create the "revolutionary cure" for baldness. forget it! In my opinion thats a step back in comparison to 5ar inhibitors. They are just working on a new angle to sell more ****.

maher, you seem happy to cherry pick and quote parts from the paper in isolation when it supports your paranoid, tin-foil hat ideology.

 

[maher]

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maher, you seem happy to cherry pick and quote parts from the paper in isolation when it supports your paranoid, tin-foil hat ideology.

Of course I filter out MOUSE MODEL EXPERIMENTS! Did you know that German scientiests cured mice infected with HIV in 2010? You are obviously incapable of inteligente debate, insulting is the only thing you're good in.

 

[maher]

It just didn't work, as all the other "mad scientist" treatments people on internet forums came up with.

Don't waste your time arguing with maher. If I recall well, he was the one vehemently advocating that masturbation caused hair loss. Enough said.

As usual.. FredThePrick pops up when you need him the most and constructivly contributes to debate. Fred, you are a liar and hypocrite.

I never said masturbation causes hair loss but only that there is a relation: masturbation -> DHT (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2549675/pdf/bmj00593-0017.pdf).

I also recall numerous of posts Fred bashed, involving "mouse studies."

And, Fred.. keep giving me neg. reps. Having "red card" bellow my nick is nothing but complimentary on this forum. tnx.

 

[bushbush]

Of course I filter out MOUSE MODEL EXPERIMENTS! Did you know that German scientiests cured mice infected with HIV in 2010? You are obviously incapable of inteligente debate, insulting is the only thing you're good in.

Again maher, it is clear you have not actually read (or understood, which is fine, but either way you are not in an informed enough position to criticise) the study in question. PGD2 was shown to have the same effect on explanted human ​hair follicles.

 

[maher]

Again maher, it is clear you have not actually read (or understood, which is fine, but either way you are not in an informed enough position to criticise) the study in question. PGD2 was shown to have the same effect on explanted human ​hair follicles.

The paper you are clinching is a viewpoint essay, not a study-... Its full of speculations and missguided conclusions lead on mouse experiments. The author is pissing through his ***.. A frikin monolouge in his paper:

Reasons why PTGDS involvement in Androgenetic Alopecia makes sense
All the above is good evidence for the importance of PGDin the pathogenesis of Androgenetic Alopecia. The next question is the exact degree of importance. Is PGD the dominant agen which is downstream of testosterone and inhibits hair growth? Or is it one of many agents and itself only a minor contributor to Androgenetic Alopecia. The following observations support that PGD might be a dominant player, though clearly more .... bla bla..

Thats just ridicilous..

 

[bushbush]

Wrong again. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/ Please read before spouting further misinformed nonsense.

 

[abcdefg]

We are in the same spot as back when this discovery first came out. Guessing how important this might be for prevention/regrowth and if we will ever see any real treatment based off this. Not exactly the cure in 2 years most of the media told us though

 

[I.D WALKER]

The abstract references selenium chloride (59) as a potential future treatment. Does anyone care to touch this one?

 

[peacemaker]

The abstract references selenium chloride (59) as a potential future treatment. Does anyone care to touch this one?

God no. There are 100 things to try before messing with Selenium.

- - - Updated - - -

The abstract references selenium chloride (59) as a potential future treatment. Does anyone care to touch this one?

God no. There are 100 things to try before messing with Selenium.

 

[Homie]

A quote so nice, he said it twice!

PGD2 was, and always will be, bull****.

 

[dan1938]

We are in the same spot as back when this discovery first came out. Guessing how important this might be for prevention/regrowth and if we will ever see any real treatment based off this. Not exactly the cure in 2 years most of the media told us though

Has anyone had success in at least maintaining using PGD2 inhibitors? I am interested in maintaining at this point. I have tried every available topical and systemic anti-androgen out there from finasteride to RU and sadly I can't touch any of them, at least not for the foreseeable future. Even Fluridil is giving me sides for f**** sake. Right now I am down to using AHk-Cu, derma rolling, emu-oil for treatment. I will be very happy to maintain what I have, but I have run out of options. And the irony is that all the things that give me sides work very well for me.

 

[Sparky4444]

when I used CET on my temples, I saw DEFINITE fuzzies sprout up...DEFINITE...more than I ever got with minoxidil, by FAR....but I didn't see it through long enough to see if they'd go terminal...after following casperz, he only got so far....I opted out of CET as I was feeling ill effects of it

 

[theRA]

I opted out of CET as I was feeling ill effects of it

what kind of ill effects?

 

[Swoop]

Again maher, it is clear you have not actually read (or understood, which is fine, but either way you are not in an informed enough position to criticise) the study in question. PGD2 was shown to have the same effect on explanted human ​hair follicles.

Remember, bushbush was so convinced of the prostaglandin angle :roll:.