wookster
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Perhaps this is an important clue?
http://cat.inist.fr/?aModele=afficheN&cpsidt=13646651
http://cat.inist.fr/?aModele=afficheN&cpsidt=13646651
Effects of gonadal steroid hormones on the thymus gland were microscopically examined. Thymic weight increased in all the groups after gonadectomy. Testosterone, estrogen, and estrogen + progesterone treatment decreased thymic weight after gonadectomy. Progesterone treatment also decreased weight, but there was no statistical significance. In the light microscopy, testosterone and estrogen treatment induced a loss of lymphoid elements from the thymic cortex, increased the number of phagocytic macrophages and mast cells, and enlarged blood vessels and connective tissue were observed in the thymic medulla. In the electron microscopic study it was observed that rough endoplasmic reticulum enlarged in the thymic lymphocytes. The same results were also found after estrogen + progesterone treatment. No histologically identifiable changes were observed in the thymus gland after progesterone treatment. This study demonstrated that the thymus gland undergoes involution after testosterone and estrogen treatment, but not progesterone, following gonadectomy.
