What if you added stuff to minoxidil. to make it more effective?

[Jacob]

There are many natural remedies on the market that claim to address hair loss and thinning hair. But very few of these products have been adequately tested. Over the past few months alone, herbs such as Chinese Knotweed and ginseng have been cited in the medical literature as hopeful agents for “follically challengedâ€￾ men and women. However, I generally don’t mention such findings because they rarely, if ever, produce cosmetically relevant results. That’s why I’m happy to report that a publication in the July 14th, 2011 issue of the Journal of Dermatological Treatment offers something dramatically different – a human study with an optimistic outcome. According to the paper, a blend of the popular have loss drug minoxidil and an extract of Curcuma aeruginosa (blue and pink ginger) may actually promote hair regrowth and reduce hair shedding. In vitro experiments indicate that C. aeruginosa extracts interfere with the conversion of testosterone to dihydrotestosterone (DHT). Lowering DHT in hair follicles may counteract the progression of androgenetic alopecia (Androgenetic Alopecia) or male pattern baldness. In the current trial, a 6 month intervention involving 87 men with Androgenetic Alopecia was undertaken. The study called for the volunteers to apply the herbal medication or an inactive topical formula twice daily. The conclusion of the paper states, “In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growthâ€￾. (7,8,9)

http://www.healthyfellow.com/896/share-your-knowledge/

Have there been studies like this with topical finasteride and dutasteride? Seems there's something out there..........

 

[ripple-effect]

Ok but what's your point? This is still a 5AR inhibitor, it's just a natural one, but you would still get the same side effects associated with 5AR inhibitors IE: finasteride, dutasteride, etc. So why not just use Topical finasteride, or dutasteride, what's the difference?

Just because they happen with finasteride and dutasteride does not mean it applies to natural DHT inhibitors as well. It has been shown that topical finasteride and dutasteride is absorbed systemically, but show me what is your basis for the claim "Natural is also absorbed systemically" to the point where this would be a concern for side effects? There are topical natural DHT Inhibitors that only inhibit locally.

 

[hairhoper]

Just because they happen with finasteride and dutasteride does not mean it applies to natural DHT inhibitors as well.

Um it's more likely it does apply in just the same way than your idea that by some *magic* no natural DHT inhibitors get absorbed systemically.

Where is your proof they only inhibit locallty?

Btw study is pretty useless in showing the efficacy of the natural 5ar inhibitor because they don't compare to a minoxidil only group.

 

[Bryan]

Just because they happen with finasteride and dutasteride does not mean it applies to natural DHT inhibitors as well.

Um it's more likely it does apply in just the same way than your idea that by some *magic* no natural DHT inhibitors get absorbed systemically.

Where is your proof they only inhibit locallty?

Nobody should make the ridiculous claim that no natural 5a-reductase inhibitor (let's try to stick to the same terms used by doctors and scientists) gets absorbed systemically; it depends entirely on what specific chemical substance we're talking about (natural or synthetic).

Here's a screamingly obvious example of a "natural substance" which doesn't get absorbed systemically, and inhibits 5a-reductase only locally where applied: fatty acids (GLA, ALA, LA, etc.). The very long, careful, and thorough study done on hamsters by Liang & Liao et al showed that the fatty acids affected ONLY the flank-organs to which they were applied, and not the opposite flank-organ. A similar result was obtained by the same researchers in a human test, in which a small amount of GLA (gamma-linolenic acid) suppressed sebum production only where applied to the forehead of a human volunteer.

 

[blaze]

Just because they happen with finasteride and dutasteride does not mean it applies to natural DHT inhibitors as well.

Um it's more likely it does apply in just the same way than your idea that by some *magic* no natural DHT inhibitors get absorbed systemically.

Where is your proof they only inhibit locallty?

Nobody should make the ridiculous claim that no natural 5a-reductase inhibitor (let's try to stick to the same terms used by doctors and scientists) gets absorbed systemically; it depends entirely on what specific chemical substance we're talking about (natural or synthetic).

Here's a screamingly obvious example of a "natural substance" which doesn't get absorbed systemically, and inhibits 5a-reductase only locally where applied: fatty acids (GLA, ALA, LA, etc.). The very long, careful, and thorough study done on hamsters by Liang & Liao et al showed that the fatty acids affected ONLY the flank-organs to which they were applied, and not the opposite flank-organ. A similar result was obtained by the same researchers in a human test, in which a small amount of GLA (gamma-linolenic acid) suppressed sebum production only where applied to the forehead of a human volunteer.

Bryan I have heard you speak on these free fatty acids a few times now and I have also read you make reference to that human study.

I have also read you say that finasteride does not inhibit sebum production. I have also heard you say that neither does dutasteride in light of the MK386 5AR1 inhibitor which apparently according to you didnt benefit acne at all.

Question: if MK386, Dutasteride nor finasteride inhibit sebum production through suppressing 5AR, then how do these free fatty acids do so via the same method of action?

 

[Jacob]

I think I'd rather have some ginger absorb systemically than finasteride or dutasteride :shock:

 

[Bryan]

Bryan I have heard you speak on these free fatty acids a few times now and I have also read you make reference to that human study.

I have also read you say that finasteride does not inhibit sebum production. I have also heard you say that neither does dutasteride in light of the MK386 5AR1 inhibitor which apparently according to you didnt benefit acne at all.

Question: if MK386, Dutasteride nor finasteride inhibit sebum production through suppressing 5AR, then how do these free fatty acids do so via the same method of action?

I don't really know for sure whether or not MK386 or dutasteride reduce sebum production, although it seems likely that they would, especially based on the results of the experiments with the fatty acids. I've said a number of times over the years that I find it shocking that as far as I know, sebum production has never been tested before-and-after MK386 or dutasteride. MK386's lack of effect on acne specifically has been tested and documented, but not any effect on sebum.

 

[knowingyou]

minoxidil with saw palmetto got rid of thinning at the back of my head where dutas and regular minoxidil hadn't over a 2 year period.

Interesting, how do you mix minoxidil and saw palmetto, can you give more details please, eg. what is the ratio? Thanks a lot!!!!