what do You think? finasteride + minoxidil... bad combination???

[michas100]

...."Review paper

Finasteride in androgenetic alopecia in men
Hanna Walkowiak
Katedra i Klinika Dermatologii Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu,
kierownik Katedry i Kliniki: prof. dr hab. n. med. Wojciech Silny
Post Dermatol Alergol 2007; XXIV, 3: 133–139
Abstract
Androgenetic alopecia in men occurs in the majority of men over 40 years old and is becoming a significant
psychological problem. Androgens have profound effects on scalp and body hair in the human scalp. Testosterone
acts in tissues after conversion into dihydrotestosterone. Miniaturization of the scalp hair follicles due to the
androgens’ activity constitutes the process background. The alpha 5 reductase enzyme, a key mediator of male
pattern loss participating in testosterone metabolism, plays a significant role in the disease aetiopathogenesis.
Diagnosis of andogenetic alopecia was based on an interview and the clinical picture. The clinical picture is quite
typical and consists of hair loss in the fronto-parietal area. The 8-step Hamilton-Norwood scale is used to evaluate
the severity of the disease. The treatment of androgenetic alopecia is not always successful, but has psychological
importance. Finasteride is one of the drugs inhibiting androgenetic alopecia in men. The best effects are seen when
finasteride is administrated at a dose of 1 mg/day for 24 months. The drug is usually well tolerated and if any adverse
events occur, in most cases they are not a reason to interrupt the treatment.
Key words: androgenetic alopecia in men, alpha 5 reductase enzyme, finasteride.
Also in this article they write that minoxidil and finasteride is bad combination (they have good results on animals but results on humans where bad/poor) and when it's use like a combo (together) then the results are poor than only minoxidil or only finasteride is a good combination BTW They write when you take away minoxidil(double curation) and continue finasteride your hair will goes hard tellogen phase ... Do you agree with it? This article is wrote in polish language so i can translate it correctly

 

[phish]

bs the big 3 is the what you need to get on, finasteride,rogain,nizoral.

 

[Pondle]

There are studies on PubMed that indicate that the best results are obtained through using finasteride and minoxidil in combination.

Comparative efficacy of various treatment regimens for androgenetic alopecia in men.

Khandpur S, Suman M, Reddy BS.
Department of Dermatology and S.T.D., Maulana Azad Meical College and Associated Lok Nayak Hospital, New Delhi, India.

Our understanding of the aetiology of androgenetic alopecia (Androgenetic Alopecia) has substantially increased in recent years. As a result, several treatment modalities have been tried with promising results especially in early stages of Androgenetic Alopecia. However, as far as has been ascertained, there is no comprehensive study comparing the efficacy of these agents alone and in combination with each other. One hundered male patients with Androgenetic Alopecia of Hamilton grades II to IV were enrolled in an open, randomized, parallel-group study, designed to evaluate and compare the efficacy of oral finasteride (1 mg per day), topical 2% minoxidil solution and topical 2% ketoconazole shampoo alone and in combination. They were randomized into four groups. Group I (30 patients) was administered oral finasteride, Group II (36 patients) was given a combination of finasteride and topical minoxidil, Group III (24 patients) applied minoxidil alone and Group IV (10 patients) was administered finasteride with topical ketoconazole. Treatment efficacy was assessed on the basis of patient and physician assessment scores and global photographic review during the study period of one year. At the end of one year, hair growth was observed in all the groups with best results recorded with a combination of finasteride and minoxidil (Group II) followed by groups IV, I and III. Subjects receiving finasteride alone or in combination with minoxidil or ketoconazole showed statistically significant improvement (p<0.05) over minoxidil only recipients. No signifcant side-effects related to the drugs were observed. In conclusion, it is inferred that the therapeutic efficacy is enhanced by combining the two drugs acting on different aetiological aspects of Androgenetic Alopecia.

 

[michas100]

Thanks Pondle and Phish so I was wrong but why why when I appied minoxidil("Loxon" lotion) and finasteride(proscar) and Ketoxin(2% ketokonazol) for about 5 months my hair slowly gone... that in the mirror I can see my skin ... :-( I am scared ... I decided change Liquid minoxidil to Rogaine foam Is that good? Is glikol inside liquid minoxidil is bad for my so that my hair going out (I was applied minoxidil on the temple of head) :cry:

 

[CCS]

that is odd. oral finasteride outperformed minoxidil. I thought minoxidil regrew over 50% more hair than finasteride at the one year mark. It is not until later that hair loss brings the minoxidil group lower than the finasteride group.

 

[lain]

Thanks Pondle and Phish so I was wrong but why why when I appied minoxidil("Loxon" lotion) and finasteride(proscar) and Ketoxin(2% ketokonazol) for about 5 months my hair slowly gone... that in the mirror I can see my skin ... :-( I am scared ... I decided change Liquid minoxidil to Rogaine foam Is that good? Is glikol inside liquid minoxidil is bad for my so that my hair going out (I was applied minoxidil on the temple of head) :cry:

After 5 months of liquid I swapped to the foam too... Its been 3 months on the foam and hair still receding at the same rate... So I dont know... seems it does not make any difference.

 

[michas100]

Ohhh that sad what should we do? I maybye reduce proscar to 5 pices like that

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