what do we know about FGF5? Study attached

[fugged]

Just reading on increasing anlagen phase, which I need, after the cbd thread. Seems Japanese rose extract has some FGF5 inhibitory effect.

Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process​

Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process - PubMed

Isolates from the monoterpenoid family displayed efficacy in FGF5 inhibition in vitro. A topical formulation containing a leading isolate significantly improved AT ratio, reduced hair fall and increased apparent hair density in the tested population of men and women.

pubmed.ncbi.nlm.nih.gov

 

[partysnacks]

We also screened a number of isolates from the monoterpene family (Figure 1) including 3-carene, l-carveol, 1,8-cineole, β-citronellol, dl-rose oxide, geraniol, geranyl acetate, lin-alool, linalyl acetate, l-menthol, nerol, piperitone, α-terpineol, (−)terpinen-4-ol, (+)terpinen-4-ol and (±)terpinen-4-ol. The monoterpenoid isolates were sourced from Tokyo Chemical Industries (Tokyo, Japan) except for 3-carene, l-carveol and dl-rose oxide, which were kindly provided by Nippon Terpene Chemicals, Inc. (Kobe, Japan). A selection of the above will hereafter be referred to as MTP3–MTP6 without disclosure of their identities for reasons of commercial protection.

Saw this and the mention of "monoterpenoids" being inhibitors of FGF5 (mainly MTP3, but they don't say which terpene that is). Cannabis contains many "terpenoids", including monoterpenoids:

Fig. 3 Monoterpenoids commonly encountered in cannabis (all structures...

Download scientific diagram | Monoterpenoids commonly encountered in cannabis (all structures drawn by EBR using ChemSketch 2015.2.5). from publication: Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads | The golden age of cannabis pharmacology began in the 1960s as Raphael...

www.researchgate.net

So, IF (big if) CBD does noticeably help hair growth, I wonder if this is one of the reasons why.

 

[partysnacks]

Also found what looks to be the patent for their monoterpenoid-based treatment: https://patents.google.com/patent/US20160374979A1/en

However, it looks like it was abandoned lol?