We need PROTEASOME INHIBITORS!!

[ProteasomeInhibitorsFTW]

My other colorfully-worded post probably won't be accepted I guess, hopefully this one will.

Seriously, why is it nothing but "finasteride this minoxidil that"? Proteasome inhibitors don't destroy your sexuality and manhood and make you a fat, boob-possessing, estrogen-laded wuss like anti-androgens including finasteride and dutasteride, do. They also wouldn't give you a freggin' heart attack or make you look like a hideous old man like minoxidil SO often does.

Proteasome inhibitors have been shown to be much more effective growth stimulants than minoxidil. People report serious reversal of Norwood stages, with them.

MG-132 is available online from bulk suppliers..why not just fool them into shipping that stuff to our "company", make a bulk group buy, after determining the optimum dose, delivery method and vehicle, etc.? Or other more easily available (natural?) proteasome inhibitors, possibly?

This seems like the only possible key to solving hairloss, other than being an extremely unusual responder to finasteride/dutasteride/minoxidil etc., or having a hair transplant or simply hitting a new self-disrespecting low, and wearing a darn wig.

We need to discuss and try to obtain proteasome inhibitors, people!!

Watchu think??

 

[I.D WALKER]

I think clinical double-blind studies would be helpful. Thanks for sharing.

 

[ProteasomeInhibitorsFTW]

You obviously haven't tried to follow the research on proteasome inhibitors or their effect on hair loss, but consider this, at the very least (one out of many examples, not even gonna talk about actual people who reported massive regrowth on PSI):

http://www.ncbi.nlm.nih.gov/pubmed/23963711

 

[ProteasomeInhibitorsFTW]

[h=1]Partial proteasome inhibitors induce hair follicle growth by stabilizing β-catenin.[/h]Yucel G1, Van Arnam J, Means PC, Huntzicker E, Altindag B, Lara MF, Yuan J, Kuo C, Oro AE.
[h=3]Author information[/h]

[h=3]Abstract[/h]The activation of tissue stem cells from their quiescent state represents the initial step in the complex process of organ regeneration and tissue repair. While the identity and location of tissue stem cells are becoming known, how key regulators control the balance of activation and quiescence remains mysterious. The vertebrate hair is an ideal model system where hair cycling between growth and resting phases is precisely regulated by morphogen signaling pathways, but how these events are coordinated to promote orderly signaling in a spatial and temporal manner remains unclear. Here, we show that hair cycle timing depends on regulated stability of signaling substrates by the ubiquitin-proteasome system. Topical application of partial proteasomal inhibitors (PaPIs) inhibits epidermal and dermal proteasome activity throughout the hair cycle. PaPIs prevent the destruction of the key anagen signal β-catenin, resulting in more rapid hair growth and dramatically shortened telogen. We show that PaPIs induce excess β-catenin, act similarly to the GSK3β antagonist LiCl, and antagonize Dickopf-related protein-mediated inhibition of anagen. PaPIs thus represent a novel class of hair growth agents that act through transiently modifying the balance of stem cell activation and quiescence pathways.
Copyright © 2013 AlphaMed Press.

 

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what are proteasome inhibitors

Actually, calcification is the missing piece of the hair loss puzzle