Vitamin D Recepter (vdr) Defunctional In Androgenetic Alopecia?

[HairCook]

Hi,

I am reading tons of RPs recently, and am connecting them more or less in models with ppt and excel.

Redensyl, probably already considered as snake oil, did show some VDR increasing effect in its study, which is why I am testing it currently. (http://www.nardev.com/UploadSection/ProdCat-276-1446515551.pdf)

Now there has been a new study this month on pubmed regarding a VDR gene mutation and alopecia.(
https://www.ncbi.nlm.nih.gov/pubmed/2912736)

Next I was looking for was a way to stimulate VDR expression aside from Redensyl of course.
I came to apoM which increases VDR stimulation as following RP states:
https://www.ncbi.nlm.nih.gov/pubmed/29067439

This is the point where it got me really, apoM expression can happen according to a paper through IGF-1(!), TGF(!), PAF and leptin. I read a lot of IGF-1 and TGF regarding hair growth. However this is the first time I heard that it was connected to vitamin D. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC523857/)

This paper states that VDR modulates PGE2 synthesis in the lungs.

This is the puzzle I ended up for now with, if someone has more info I would love to hear more. I am not coming form this field and majored in business, so I am really new to this field, would love to here more also from somebody working in this field, too!

Updated model and other papers:
https://www.ncbi.nlm.nih.gov/pubmed/29112142
https://www.ncbi.nlm.nih.gov/pubmed/28944088
https://www.ncbi.nlm.nih.gov/pubmed/28848172

Looks like DHT is actually downregulating apoM!
https://www.ncbi.nlm.nih.gov/pubmed/23216709

 

[Afro_Vacancy]

Welcome @HairCook.

I'm from an astronomy background myself, and what I suspect is that a large part of pubmed is fraudulent. At this point, hair loss has been cured dozens of times, and yet we're all still fucked.

The vitamin D receptors angle is relatively new and thus may have promise. There's a broccoli extract that helps vitamin D receptors that's been shown to be good to fight type II diabetes as well.

As far as I know, nobody here has tried this angle.

 

[HairCook]

I assume Diet isnt that relevant regarding Androgenetic Alopecia aside you got something like diabetes. Broccoli comes with a lot like Vit C, B3... and Quercetin which might have some minor benefits for the skin, not sure about its extracts bioavailibility though, quercetin and curcumin are often advertised with its great benefits on paper but end up doing nothing due to its bioavailibility.

The approach might be taking 3 angles, TGF-b control (might be a reason why taurine was brought up back in the days, it seems to be a natural TGF-Inhibitor, but just one example), IGF-1 stimulation (raspberry ketone; isoflavone+capsaicin or any sensoric stimulation like blue light), add vit D supplement, stimulate VDR (Redensyl) and then take some PGE2 (limonene...) and wnt agonist(vit b12, lithium chloride...).

 

[Afro_Vacancy]

I assume Diet isnt that relevant regarding Androgenetic Alopecia aside you got something like diabetes. Broccoli comes with a lot like Vit C, B3... and Quercetin which might have some minor benefits for the skin, not sure about its extracts bioavailibility though, quercetin and curcumin are often advertised with its great benefits on paper but end up doing nothing due to its bioavailibility.

The approach might be taking 3 angles, TGF-b control (might be a reason why taurine was brought up back in the days, it seems to be a natural TGF-Inhibitor, but just one example), IGF-1 stimulation (raspberry ketone; isoflavone+capsaicin or any sensoric stimulation like blue light), add vit D supplement, stimulate VDR (Redensyl) and then take some PGE2 (limonene...) and wnt agonist(vit b12, lithium chloride...).

It's not the broccoli, it's the broccoli extract which contains sulphorofane, or something like that. It's been tested in isolation and has a positive impact on type II diabetes. Type II diabetes correlates sharply with male pattern baldness.

Are you going to take 10 or 15 supplements?

 

[Trichosan]

I love broccoli and eat it frequently.

http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/indole-3-carbinol

Some observational studies have reported significant associations between high intakes of cruciferous vegetables and lower risk of several types of cancer (1). Cruciferous vegetables differ from other classes of vegetables in that they are rich sources of sulfur-containing compounds known as glucosinolates (for detailed information, see the article on Cruciferous Vegetables) (2). The potential health benefits of consuming cruciferous vegetables are attributed to compounds derived from the enzymatic hydrolysis (breakdown) of glucosinolates. Among these compounds is indole-3-carbinol (I3C), a compound derived from the degradation of an indole glucosinolate commonly known as glucobrassicin (Figure 1).