Of course there is already numerous reported use of CB-03-01. Says weaker than RU,at least 2x stronger than fina and with no side effects
Edit :
A) These results inspire a new strategy that can restore morphological transitions and rescue the hair-forming
ability of adult organoids:
1) continuous PKC inhibition; and
2) timely supply of growth factors (IGF, VEGF), Wnts, and MMPs.
B) Vitamin D deficiency was present in 64.8% of patients, with 32.96% having mild, 17.60% moderate and 14.25% severe deficiency. Vitamin D values were significantly associated with all hair loss type (p=0.02), with
central centrifugal scarring alopecia having lowest vitamin D levels, and Androgenetic Alopecia the highest.
-> This is confusing me. Does it means Androgenetic Alopecia people have too much VitD levels?
C) The novel humanized mouse model of Androgenetic Alopecia holds great potential to systematically explore new candidate anti-Androgenetic Alopecia agents at the preclinical level and to better characterize the as yet incompletely understood mechanisms of action of traditional agents such as minoxidil.
-> Mouse : 1 / Human : 0
D) Our data revealed upstream first responses of KATP channel in HDPC induced by minoxidil sulfate.
The opening of KATP channel by minoxidil sulfate critically contributes to the promotion of therapeutic potency for
hair growth. The amplification of signaling via KATP channel activation may be essential and effective strategy for AAG
E) More specifically, genes involved in the monounsaturated fatty acid and triglyceride synthesis were proven fundamental for proper hair development. In
addition, more evidence has been advocating that essential dietary fatty acids, their metabolites and their nuclear receptors are influencing the hair follicle and fur in several preclinical models
F) Our data identify WNT10A
as a critical ligand controlling hair follicle progenitor cell proliferation. Together with the observation that hair
follicle stem cells are maintained in the absence of WNT10A and in balding scalp, our results suggest downstream
β-catenin pathway activation as a potential approach to ameliorate androgenetic alopecia in patients who carry a WNT10A variant.
-> Revelant with Vitexin VB-1
G) The elevated levels of plasma MMP activity in Androgenetic Alopecia patients could be consistent with hair follicle miniaturization and perifollicular fibrosis. Whether increased MMP activity puts Androgenetic Alopecia patients at risk for subclinical heart tissue remodeling is unknown.
H) Traction caused by the habit of wearing hats may facilitate colonization of the scalp by Staphylococcus aureus (Sa). Sa secreted cytotoxic proteins,
frequently detected in active DCS lesions, can act as superantigens, activating the secretion of inflammatory
cytokines, which may induce thickening of collagen. These cytokines activate the fibroblasts, causing
overproduction of the extracellular matrix, which leads to fibrosis due to its progressive accumulation.
I) Intralesional Triamcinolone Acetonide For Treatment Of Traction Alopecia
None of the patients reported any adverse effects due to the ILK. ILK
injections are usually done at a concentration of 5mg/mL
Here are the most important things from your paper for me
