Often times ive called for Help here but my posts seemed to be ignored, but anyway Im gonna help you guys now. Im from Denmark and I speak German so I guess im able to inform you about whats going on right now in German research. As you know Prof. Roland Lauster from the technical university in Berlin was able to create new hairs out of stem cells. The procedure is very difficult to understand. The first step is they take some hair follicles from the scalp, the second step is they isolate cells out of these hairs and clone them. Step three is they reconstruct the structure which is needed for hair grwoth with these cloned cells , they use a biomatrix to protect these cells while theyre growing. As you know they just grew these hairs under experimental conditions, so that the follicles were not just as strong as follicles on the human scalp. However according to a member of Lausters team the follicles created by the method should grow even better if they put the follicle into the human scalp. Clinical trials are on the way they are just searching for investors. The procedure would be comparable to a FUE Hair Transplant with the diffrence that these hairs would be created under microscopical conditions before they place them on the scalp. Right now theyre talking about five years before these method would be available on the market. If the trials would be succesfull and the predictions of Lausters team members because of the better conditions in vivo for these generated follicles would become reality theres big chance that this is the Breaktruogh! Just to inform you the technical University in Berlin is one of the leading institutes in Biotechnology in Europe these guys are really respected european scientists . Gentleman we have a new candidate for the final solution to our Problem.
Updates on German research
- Thread starter Batzadog
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dimitar_berbagod
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Re: Updates about on German research
Now where have I heard that term in reference to Germany before...? :whistle:
Now where have I heard that term in reference to Germany before...? :whistle:
Re: Updates about on German research
http://www.ncbi.nlm.nih.gov/pubmed/21277344
J Biotechnol. 2011 Jan 28. [Epub ahead of print]
De novo formation and ultra-structural characterization of a fiber-producing human hair follicle equivalent in vitro.
Lindner G, Horland R, Wagner I, Ataç B, Lauster R.
Department of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, D-13355 Berlin, Germany.
Abstract
Across many tissues and organs, the ability to create an organoid, the smallest functional unit of an organ, in vitro is the key both to tissue engineering and preclinical testing regimes. The hair follicle is an organoid that has been much studied based on its ability to grow quickly and to regenerate after trauma. But hair follicle formation in vitro has been elusive. Replacing hair lost due to pattern baldness or more severe alopecia, including that induced by chemotherapy, remains a significant unmet medical need. By carefully analyzing and recapitulating the growth conditions of hair follicle formation, we recreated human hair follicles in tissue culture that were capable of producing hair. Our microfollicles contained all relevant cell types and their structure and orientation resembled in some ways excised hair follicle specimens from human skin. This finding offers a new window onto hair follicle development. Having a robust culture system for hair follicles is an important step towards improved hair regeneration as well as to an understanding of how marketed drugs or drug candidates, including cancer chemotherapy, will affect this important organ.
http://www.ncbi.nlm.nih.gov/pubmed/10559902
Nat Cell Biol. 1999 Jul;1(3):158-64.
Noggin is a mesenchymally derived stimulator of hair-follicle induction.
Botchkarev VA, Botchkareva NV, Roth W, Nakamura M, Chen LH, Herzog W, Lindner G, McMahon JA, Peters C, Lauster R, McMahon AP, Paus R.
Department of Dermatology, Charité, Humboldt-University Berlin, Germany.
Abstract
The induction of developmental structures derived from the ectoderm, such as the neural tube or tooth, occurs through neutralization of the inhibitory activity of members of the bone-morphogenetic protein (BMP) family by BMP antagonists. Here we show that, during hair-follicle development, the neural inducer and BMP-neutralizing protein Noggin is expressed in the follicular mesenchyme, that noggin-knockout mice show significant retardation of hair-follicle induction, and that Noggin neutralizes the inhibitory action of BMP-4 and stimulates hair-follicle induction in embryonic skin organ culture. As a crucial mesenchymal signal that stimulates hair-follicle induction, Noggin operates through antagonistic interactions with BMP-4, which result in upregulation of the transcription factor Lef-1 and the cell-adhesion molecule NCAM, as well as through BMP4-independent downregulation of the 75 kD neurotrophin receptor in the developing hair follicle.
PMID: 10559902 [PubMed - indexed for MEDLINE]
Here two studies in medline:dimitar_berbagod said:
http://www.ncbi.nlm.nih.gov/pubmed/21277344
J Biotechnol. 2011 Jan 28. [Epub ahead of print]
De novo formation and ultra-structural characterization of a fiber-producing human hair follicle equivalent in vitro.
Lindner G, Horland R, Wagner I, Ataç B, Lauster R.
Department of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, D-13355 Berlin, Germany.
Abstract
Across many tissues and organs, the ability to create an organoid, the smallest functional unit of an organ, in vitro is the key both to tissue engineering and preclinical testing regimes. The hair follicle is an organoid that has been much studied based on its ability to grow quickly and to regenerate after trauma. But hair follicle formation in vitro has been elusive. Replacing hair lost due to pattern baldness or more severe alopecia, including that induced by chemotherapy, remains a significant unmet medical need. By carefully analyzing and recapitulating the growth conditions of hair follicle formation, we recreated human hair follicles in tissue culture that were capable of producing hair. Our microfollicles contained all relevant cell types and their structure and orientation resembled in some ways excised hair follicle specimens from human skin. This finding offers a new window onto hair follicle development. Having a robust culture system for hair follicles is an important step towards improved hair regeneration as well as to an understanding of how marketed drugs or drug candidates, including cancer chemotherapy, will affect this important organ.
http://www.ncbi.nlm.nih.gov/pubmed/10559902
Nat Cell Biol. 1999 Jul;1(3):158-64.
Noggin is a mesenchymally derived stimulator of hair-follicle induction.
Botchkarev VA, Botchkareva NV, Roth W, Nakamura M, Chen LH, Herzog W, Lindner G, McMahon JA, Peters C, Lauster R, McMahon AP, Paus R.
Department of Dermatology, Charité, Humboldt-University Berlin, Germany.
Abstract
The induction of developmental structures derived from the ectoderm, such as the neural tube or tooth, occurs through neutralization of the inhibitory activity of members of the bone-morphogenetic protein (BMP) family by BMP antagonists. Here we show that, during hair-follicle development, the neural inducer and BMP-neutralizing protein Noggin is expressed in the follicular mesenchyme, that noggin-knockout mice show significant retardation of hair-follicle induction, and that Noggin neutralizes the inhibitory action of BMP-4 and stimulates hair-follicle induction in embryonic skin organ culture. As a crucial mesenchymal signal that stimulates hair-follicle induction, Noggin operates through antagonistic interactions with BMP-4, which result in upregulation of the transcription factor Lef-1 and the cell-adhesion molecule NCAM, as well as through BMP4-independent downregulation of the 75 kD neurotrophin receptor in the developing hair follicle.
PMID: 10559902 [PubMed - indexed for MEDLINE]
Yeah Ive heard about the studies in the US. But the germand research looks more promissing to me. The only problem is that t has not been noticed so far like Ari or Histogen. But it somehow seems to me like it is very promissing because the generated follicles grown under embryonic conditions would get more support from supplements and vitamins if they really put them into humans or animal skin. This assumption seems logical to me and its not like the case in 2004 in Pensylvania, this time they really rebuild a follicle so that theyre even able to change things if it should not work.
To me also, and this thanks to the publication mentioned previously. This exerpt:Batzadog said:
is without doubt the most concrete scientific progression in this domain. If it will lead to a routinely applied commercial solution or not is another problem though.
Does any one know when they will have results if this will actually be a sucess or not? I read somewhere (can`t remeber where) that they were supposed to have some results within the year 2011, but I dunno if this is correct or not. Or what the next step for them is? Planting it on a human head and see if it grows or not?
I see that they are talking about five years from now, but I guess that they will have more information within shorter amount of time that that. All questions aside, I really and fully believe that "we" will have some kind of cure (that can give a man/women a full head of hair again) within the next five, max ten, years. Maybe this is the sollution? I sure to think so!
I see that they are talking about five years from now, but I guess that they will have more information within shorter amount of time that that. All questions aside, I really and fully believe that "we" will have some kind of cure (that can give a man/women a full head of hair again) within the next five, max ten, years. Maybe this is the sollution? I sure to think so!
No one can tell. If what the paper abstract says is precise, then this is an evolution that has the full potential to provide a real cure.Letac said:Maybe this is the sollution? I sure to think so!
But from the point we are now to commercialise a male pattern baldness cure is a long way: securing funds (to consolidate, optimize and tweak the process), statistically testing performance and safety, going through regulations, and probably fighting competition.
This is what everyone here wants to believe. It is not the ideal solution of in situ (that is, on the scalp) surgery-free hair multiplication, but the operation would be reduced to just implant the new hair and let it grow, instead of harvesting grafts from the donor area and then implanting them as it is done today. If it works like that it would be a breakthrough compared to what we have today because the biggest barrier (limited donor area) will be lifted.Rutt said:
Time will tell.
well yes, in situ, surgery free would be the holy grail cure, but extracting a few donor hairs, cloning them via stemcells, and then having virtually unlimited supply would in theory "cure" baldness [you can go back to NW1], but it would require a few surgeries and probably a lot of money.
It depends on the cost of the hair multiplication phase. If this is optimized to produce high yields, then there is the potential to have an overall significantly cheaper procedure, even if the new hair has to be transplanted. The reason would be that with hair multiplication in the lab, the extraction and processing of grafts from the donor area is eliminated.Nex said:
thats' true
however i didn't think about the fact that placing grafts takes a very skilled surgeon, meaning it'd still be only about a dozen doctors in the world who would be good for this in areas like the hairline.
and unfortunatly they may have "ethical issues" even with unlimited donor..
however i didn't think about the fact that placing grafts takes a very skilled surgeon, meaning it'd still be only about a dozen doctors in the world who would be good for this in areas like the hairline.
and unfortunatly they may have "ethical issues" even with unlimited donor..
somone uk
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i don't think that would be a problem for a competent doctorRutt said:
doctors usually have to possess some adequate intelligence to become a competent doctor
someone who is so bear sh*t stupid that they oppose stem cell research really do need to have their medical licence revoked
my concern is that HM is just going to be like duke nukem forever, people have said it's around the corner but then it will just have arbitrary delays that last.....forever
Yeah i was referring to that, but if donor is unlimited there shouldn't be an ethical issue with reverting to an adolescent hairline (although, that could turn into a give away of hair transplant's, no recession at all, lol)
at that point it's just a matter of funds.
at that point it's just a matter of funds.
Jacob
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Since there's been more done with those lines that don't step on those "moral concerns"...and if one thinks of all the money and time that could have been put into THEM...let's just say it's too bad people couldn't see the light..instead of living in the dark ages.....