"The researchers focused on the interaction of the Wnt signaling pathway, which is important in embryonic development and regeneration, and bone morphogenetic proteins, which are hair growth inhibitory factors...
A breakdown of this complex signaling could uncover the roots of human hair growth irregularities and point to solutions.
For example, common male pattern baldness affects frontal and crown regions but not the back of the head. In adult humans, messaging among scalp hairs appears to stop, and every hair follicle is thought to grow independently.
“If communication between nonbalding and balding regions can be reactivated, hair growth signals can then start spreading across the entire head skin, preventing regional baldness,” Plikus said...
Plikus said that Wnt and BMP signaling activities can be regulated pharmacologically. “Our study identified the types of Wnt-BMP signaling levels that are very favorable for hair growth and the types that prevent it,” he said. “It provides the road map for optimizing Wnt-BMP levels to achieve enhanced hair growth.”
He added that the findings point toward additional signaling factors – besides Wnt and BMP – positively correlated with robust hair growth. Studying these will be the researchers’ next step."
https://news.uci.edu/2017/07/11/uci...lation-of-hair-growth-across-the-entire-body/
On Reddit, Dr. Wrassman recently referred to a new treatment that seems to have come out of this research:
"I am involved with a company called Amplifica which is working with the University of California Irvine. Amplifica’s approach to hair regrowth is based on the discovery of naturally occurring signaling molecules that prominently stimulate new hair growth. The scientific studies leading to the discovery of these molecules are based on the unique molecular biology found in the naturally occurring hairy nevi (aka hairy moles) which has been extensively studied and uniquely understood by the companies’ scientific founder.
William Rassman, M.D."
https://www.reddit.com/r/tressless/...ture_treatments_around_the/g4v4yrj/?context=3
A breakdown of this complex signaling could uncover the roots of human hair growth irregularities and point to solutions.
For example, common male pattern baldness affects frontal and crown regions but not the back of the head. In adult humans, messaging among scalp hairs appears to stop, and every hair follicle is thought to grow independently.
“If communication between nonbalding and balding regions can be reactivated, hair growth signals can then start spreading across the entire head skin, preventing regional baldness,” Plikus said...
Plikus said that Wnt and BMP signaling activities can be regulated pharmacologically. “Our study identified the types of Wnt-BMP signaling levels that are very favorable for hair growth and the types that prevent it,” he said. “It provides the road map for optimizing Wnt-BMP levels to achieve enhanced hair growth.”
He added that the findings point toward additional signaling factors – besides Wnt and BMP – positively correlated with robust hair growth. Studying these will be the researchers’ next step."
https://news.uci.edu/2017/07/11/uci...lation-of-hair-growth-across-the-entire-body/
On Reddit, Dr. Wrassman recently referred to a new treatment that seems to have come out of this research:
"I am involved with a company called Amplifica which is working with the University of California Irvine. Amplifica’s approach to hair regrowth is based on the discovery of naturally occurring signaling molecules that prominently stimulate new hair growth. The scientific studies leading to the discovery of these molecules are based on the unique molecular biology found in the naturally occurring hairy nevi (aka hairy moles) which has been extensively studied and uniquely understood by the companies’ scientific founder.
William Rassman, M.D."
https://www.reddit.com/r/tressless/...ture_treatments_around_the/g4v4yrj/?context=3
