Topicla aromatase inhibitor - estrogen causes hair loss?

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These people thought estrogen caused hair loss and created this patent

US6020327A - Control of hair growth - Google Patents

A method for treating hair loss is disclosed by topically adminstering an aromatase inhibitor to a mammal, including humans, on the area to be treated.

patents.google.com

 

[ninarosshairtherapy]

Topical aromatase inhibitors (AIs) can contribute to hair loss as a side effect. Here's how it works:

Estrogen and Hair Growth:

• Estrogen plays a role in hair growth by stimulating the hair follicles.

Aromatase Inhibitors:

• AIs are medications used to reduce estrogen levels. They work by blocking the enzyme aromatase, which converts androgens (like testosterone) into estrogens.
• This reduction in estrogen, particularly estrone, can lead to hair loss in some individuals.

Hair Loss with AIs:

• Studies show that 22.4% of breast cancer survivors using AIs reported hair loss, and 31.8% reported hair thinning.
• This hair loss is typically similar to male pattern baldness, with a receding hairline and thinning at the crown being most common.

Factors Affecting Hair Loss:

• Individual Sensitivity: Not everyone using AIs experiences hair loss. It depends on individual sensitivity to estrogen levels and genetic predisposition to hair loss.
• Duration of Use: Hair loss is more likely during the initial stages of AI treatment and may improve or stabilize over time.

Management of Hair Loss with AIs:

• Talk to your doctor: If you're experiencing hair loss with AIs, discuss it with your doctor. They can assess the severity and offer solutions.
• Alternative Treatments: There might be alternative medications or treatment plans for your condition that don't involve AIs.
• Hair Loss Treatments: Your doctor might suggest using minoxidil (Rogaine) topically to promote hair growth.
• Lifestyle Changes: Maintaining a healthy diet, managing stress, and getting enough sleep can all contribute to overall hair health.

Here are some additional points to consider:

• Benefits vs. Side Effects: The benefits of AI therapy in treating certain medical conditions often outweigh the potential side effects like hair loss.
• Weighing the Options: Your doctor will help you weigh the benefits of AI therapy against the potential side effects and discuss alternative options if necessary.

Remember: It's important to communicate openly with your doctor about any side effects you experience during treatment. They can help you manage them and ensure you receive the best possible care.