I don't know how it was possible, but it seems even topical setipiprant gave me side effects, and not the side effects that are common with this drug either. It gave me brain fog/head pressure very similar to what Propecia gave me two years ago. I used 1 mL of 5% one night back in early August and woke up the next morning feeling pretty out of it, so I decided not to do another application. The crappy feeling I had went a way in a day or two and then the next week I decided to try again. Well, it's the middle of October now and I still feel off in the head from that second try. With the Propecia I tried two years ago, I only popped two pills of 0.25 mg and was left with horrible brain fog that lasted over a month. I remember back then being very fearful that I was never going to get my mental acuteness back. I seem to be VERY sensitiveness to these drugs. Sucks. I hope I recover soon. I wish I knew of something I could do to help myself feel some sort of relief.