- Reaction score
- 1,332
BTW Swoop, I may be wrong about this, and if I am, then never mind, but I believe you said at some point about CB that will never match the effectiveness of 5-AR inhibitors. Or that might've been about Setipiprant. Either way... why wouldn't something like CB (or anything else that completely blocks the androgen receptor) be equally effective (if not more, actually, since it would prevent ALL androgens from binding to it) than Finasteride?
Provided that DHT only works at the androgen receptors and no where else.
So far it seems that based on effectiveness RU is worse than Finasteride, and CB even worse than RU, and it doesn't sound right.
If compounds like CB-03-01 or RU58841 would actually be able to completely block the androgen receptor then that would be great, or rather block all androgens from binding. Problem is they can't.
For instance if we look what is said about RU;
RU58841 is an androgen receptor (AR) inhibitor capable of blocking 70% of DHT binding
So who knows how much it actually blocks in-vivo? For all you know it might block 40% of DHT in some and in other people 70%. At the very least we can say with certainty that it doesn't stop all androgens from binding. I have read quite some literature of androgen receptor inhibitors and it is a complicated and hard task to block all androgens from binding and actually pretty much no compound till date has achieved of being a full inhibitor of the androgen receptor. Recently Dench57 came up with ODM-201, which is one of the newest generation androgen receptor inhibitors which might come close to really stop all androgens from binding. We need one that like that but one doesn't go systemic with a good safety profile.
I might have said that dutasteride > finasteride > RU > CB? In a head to head hair count trial over a longer time I think that would be the case. I can't know for sure though, that's my rough prediction on the data. Still I would put all of those treatments in a tier 1 box. CB-03-01 should have the advantage of having a very good side effect profile though like you know, we'll have to see .