- Reaction score
- 419
I stumbled upon an article from MinoxidilMax (they have some great products btw) that compared topical azelaic acid to finasteride and referenced a study that showed nice potential in azelaic acid as an inhibitor of 5ar (in high enough doses).
"In a study reported in the British Journal of Dermatology (Stamatiadis. 1988;119: 627-632), inhibition of 5-alpha reductase is virtually complete (98%) at 3 mmol/l. MinoxidilMax solutions contains 5% azelaic acid, which is 88 times the amount necessary for 98% inhibition of Type 1 and Type 2 5-alpha reductase in vitro. Both types of 5-alpha-reductase are present in the human scalp with Type 1 being the predominant isoenzyme. Allowing for the usual 4 or 5 percent absorption into the dermis and epidermis upon topical application, the amount of azelaic acid at the level of the hair follicles is at least 3 times the amount required for virtually complete inhibition of DHT synthesis."
The downside to the study is that it was done in vitro.... But still curious.. has anyone tried topical azelaic acid and had some level of success with it?
Link to the article:
https://www.minoxidilmax.com/azelaic-acid-for-hair-loss-review
Link to the study:
https://www.ncbi.nlm.nih.gov/pubmed/3207614
"In a study reported in the British Journal of Dermatology (Stamatiadis. 1988;119: 627-632), inhibition of 5-alpha reductase is virtually complete (98%) at 3 mmol/l. MinoxidilMax solutions contains 5% azelaic acid, which is 88 times the amount necessary for 98% inhibition of Type 1 and Type 2 5-alpha reductase in vitro. Both types of 5-alpha-reductase are present in the human scalp with Type 1 being the predominant isoenzyme. Allowing for the usual 4 or 5 percent absorption into the dermis and epidermis upon topical application, the amount of azelaic acid at the level of the hair follicles is at least 3 times the amount required for virtually complete inhibition of DHT synthesis."
The downside to the study is that it was done in vitro.... But still curious.. has anyone tried topical azelaic acid and had some level of success with it?
Link to the article:
https://www.minoxidilmax.com/azelaic-acid-for-hair-loss-review
Link to the study:
https://www.ncbi.nlm.nih.gov/pubmed/3207614