Brian how important is alcohol in minoxidil? I understand it is used to dissolve minoxidil and used as a delivery vehicle for penetrating the scalp to enabling more effective absorbtion. The problem lies with the drying effect left on the skin which can cause inflammation rendering it counter productive to some level. The reason i ask is someone claims to have made there minoxidil more effective by letting the alcohol content evaporate and still managed to get results.
http://jefffsbeardboard.yuku.com/to...echnique-Convert-regular-to-7-no-alcohol.html
The only way i can see this happen is that once it has dissolved the minoxidil lies saturated within the ppg and doesnt evaporate with the alcohol as quickly. Of course some of the minoxidil will evaporate with the alcohol but a lot of it will be left as a residue of mainly minoxidil saturated within ppg (effectivelly increasing the concentration of minoxidil). Now with the alcohol evaporated i suspect it will effect the level of absorbtion when applied to the scalp despite the increased concentration of minoxidil.
A company that uses one of doctor proctors ingredients (SOD's) in the brand name of nanogaine claims that there product acts the same way as minoxidil but without the harsh side effects and alcohol. Check link below.
http://www.nanogen.co.uk/res_websit...y&supplierCode=PANGAEA&cat1=134&productId=236
Another site gives an explantion of how this is possible.
It means that yes the solution dries/penetrates more
slowly but it does not dry out the hair.
Liposomal questions -
This is a fair and incisive comment/observation made by one of your readers but is not relevant to this
particular product for two reasons:
1) Capilarity - If this was any other part of the skin, the benefits
of a liposomal vehicle for improved transcutaneous absorption of an aqueous solution is unquestionable.
However this is not the same for hair products. The reason why is that Nanogaine actives are designed
to travel to the hair folicle itself.
Fortunately, normal, thinning and even vellus hair is present in what appears to be smooth/bald areas
acts as a direct transport system to the follicle using the physical and powerful priniciple of capilarity.
The same mechanism that drives water up through narrow channels from the base to the leaves of 100m
metre tall trees without any power source.
It also makes some bold claims about minoxidil possibly worsening hairloss by opening channels which could allow more dht to reach the follicles.
The mechanism of action of Minoxidil has nothing to do with its vasodilatory
effects as is commonly and incorrectly stated by pseudo-scientists.
That is increasing access to blood supply. You would be amazed at the number of so-called hair loss
experts who still band around the concept that Minoxidil 'works' by increasing the blood supply
available to the hair follicle.
In fact the increase in blood supply as a consequence of the vasodilatory effect of minoxidil is an
unfortunate side-effect that probably reduces its hair regrowth effects to a large degree.
The last thing one wants to do is increase the amount of DHT presenting to hair follicle cells that
are genetically predisposed to 'die' when they are exposed to DHT.
Taken from
http://stophairlossnow.ipbhost.com/lofiversion/index.php/t14.html
Now if this is true then not only is nanogaine a safe alternative that offers the same bennefits as minoxidil. Alcohol in minoxidil may not be needed as much once minoxidil is already dissolved in the solution. It can be absorbed through the hair which acts as a direct transporter to the follicle providing it doesnt evaporate too quickly which it wont due to the ppg keeping IT saturated on the scalp (long enough for it to be absorbed to take effect). The bottom line is this alcohol's only use at this point is to further penetrate the scalp.
My question is this do you think such as solution (nanogaine and minoxidil) will work without alcohol. Im thinking nanogaine exagerates its ability to penetrate the scalp without alcohol. I understand skin is semi permeable and is needed to be to enable us to sweat. So i guess its possible but i doubt it will be effective enough without the use of alcohol to take any real effect.
The reason i am asking such questions is i am considering mixing nanogaine with minoxidil so that the alcohol can enable nanogaine to have more effective penetration into the scalp. The result of which i hope will be more impressive hair regrowth with less scalp drying and inflammation. I understand this will weaken the minoxidil so i am thinking of using 5% minoxidil 50% diluted with 2% Nanogaine. If im correct that should bring the minoxidil solution down to 2.5% with 1% Sod'S and copper peptides (apparently nanogaine has copper peptides according to the third url link).
Inaddition to this im thinking of dissolving finestride into the solution before mixing it with nanogaine after everyones instructions on how to do it. Im thinking of using five 1mg propecia pills into the solution. Why might i do this you might thinking. I cant full tollerate propecia internally (gyno) and have many pills left over i dont want to waste. Further more im a choosing to use 5 pills instead of one because various sources tell me topical finasteride isnt effective enough because not enough finestride penetrates the scalp. Its my guess that by increasing the concentration of finestride into the solution it will increase the probability of enough finestride penetrating the scalp to take a more noticeable effect.
Of course this is just an idea and im not going to try it until i know more about it. If it turns out alcohol isnt really needed there wont be much point in mixing both nanogaine and minoxidil as i can just use them separatelly. The idea is just to increase the absorbtion power of nanogaine with some added extras.
Do you think such a solution could work?
