- Reaction score
- 563
Duasteride blocks 5AR1 100x more than Finasteride and 5AR2 around 3x more than Finasteride. The fact is some people may not do great long term on Finasteride and others may do better of Duasteride. 5AR2 is what is responsible for hair loss and Duasteride more completely inhibits this. It inhibiting 5AR1 is unhelpful and can cause worrying long term side effects such as lipid issues. If I were to take Duasteride, I would take a lower dosage such as .5mg 3x per week. Before switching from Finasteride to Duasteride I would try oral+topical Finasteride and oral Minoxidil (low dose).