Sanchez1234
Experienced Member
- Reaction score
- 311
Hi guys, i am long battler against gyno due hormonal hairloss medications and i've tried multiple treatments.
Tamoxifen and Raloxifene were the best against gyno but the problem is always the same, hairloss picks up while on anti-gyno treatment (even on hairloss medications).
While we try to battle hairloss locally with topicals (RU, minoxidil, CB etc) we dont have any good topicals against gyno locally. I couldnt find any results here on the forum but i've done some research in hopes to find a anti-gyno treatment that might be used while on hairloss medications.
Might topical tamoxifen be the answer?
Please read the text below and let me know what you guys think?!!
"Seema Khan, MD, professor of surgery, found a new skin gel that reduced the growth of cancercells minimizing dangerous side effects. A gel form of tamoxifen applied to the breasts of women with noninvasive breast cancer reduced the growth of cancer cells to the same degree as the drug taken in oral form but with fewer side effects that deter some women from taking it, according to new Northwestern Medicine research."
Source: http://www.womenshealth.northwestern.edu/blog/tamoxifen-gel-form-effective-less-side-effects
"To explore alternatives to oral tamoxifen that might have fewer side effects, researchers are testing a topical form of the drug in two clinical trials. These randomized placebo-controlled studies are evaluating a gel formulation of tamoxifen called 4-hydroxytamoxifen (4-OHT) that waomen apply directly to the breasts.
Source: https://www.cancer.gov/news-events/cancer-currents-blog/2018/tamoxifen-gel-breast-cancer-prevention
"Our trial is testing 4-OHT gel, which is an active form of tamoxifen, in women with DCIS.When tamoxifen is taken by mouth, it goes through the gut and into the liver, where it’s broken down into two main active forms, 4-OHT and endoxifen. If we put any drug on the skin that goes directly into the breast, it has to be an active form like 4-OHT, because it won’t pass through the liver to be activated.
I can say that the circulating gel levels in the body are extremely low compared with oral tamoxifen.
If it passes and goes to phase 2, they’ll start looking at its effectiveness. As an oral drug, this was too toxic to use in healthy women. "
Source: https://www.curetoday.com/publicati...19/getting-under-your-skin-with-tamoxifen-gel
Tamoxifen and Raloxifene were the best against gyno but the problem is always the same, hairloss picks up while on anti-gyno treatment (even on hairloss medications).
While we try to battle hairloss locally with topicals (RU, minoxidil, CB etc) we dont have any good topicals against gyno locally. I couldnt find any results here on the forum but i've done some research in hopes to find a anti-gyno treatment that might be used while on hairloss medications.
Might topical tamoxifen be the answer?
Please read the text below and let me know what you guys think?!!
"Seema Khan, MD, professor of surgery, found a new skin gel that reduced the growth of cancercells minimizing dangerous side effects. A gel form of tamoxifen applied to the breasts of women with noninvasive breast cancer reduced the growth of cancer cells to the same degree as the drug taken in oral form but with fewer side effects that deter some women from taking it, according to new Northwestern Medicine research."
Source: http://www.womenshealth.northwestern.edu/blog/tamoxifen-gel-form-effective-less-side-effects
"To explore alternatives to oral tamoxifen that might have fewer side effects, researchers are testing a topical form of the drug in two clinical trials. These randomized placebo-controlled studies are evaluating a gel formulation of tamoxifen called 4-hydroxytamoxifen (4-OHT) that waomen apply directly to the breasts.
Source: https://www.cancer.gov/news-events/cancer-currents-blog/2018/tamoxifen-gel-breast-cancer-prevention
"Our trial is testing 4-OHT gel, which is an active form of tamoxifen, in women with DCIS.When tamoxifen is taken by mouth, it goes through the gut and into the liver, where it’s broken down into two main active forms, 4-OHT and endoxifen. If we put any drug on the skin that goes directly into the breast, it has to be an active form like 4-OHT, because it won’t pass through the liver to be activated.
I can say that the circulating gel levels in the body are extremely low compared with oral tamoxifen.
If it passes and goes to phase 2, they’ll start looking at its effectiveness. As an oral drug, this was too toxic to use in healthy women. "
Source: https://www.curetoday.com/publicati...19/getting-under-your-skin-with-tamoxifen-gel
