The Study of Growth Factors in Patients with Androgenic Alopecia

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Studying the causes of hair loss and improving the methods of alopecia therapy are among the most important trends in dermatology. The interest is determined by the fact that pathogenic mechanisms of hair loss are poorly studied, current methods of therapy are not always effective enough, and the existing theories and assumptions do not reveal fully the mechanisms of hair loss. Undoubtedly, the development of new pharmacological means and methods of alopecia therapy is possible only owing to better understanding of hair loss patterns at the pathophysiological level. The purpose of this study was to investigate the role of the VEGF, KGF, EGF, TGF-β1 growth factors in the development of androgenic alopecia in men and women. This study demonstrates gender differences in the pathogenesis of androgenic alopecia. The obtained data give reason to assume the influence of other factors on the development of androgenic alopecia in men.

Growth factor Trial groups	VEGF (relative area of expression, %)	KGF (relative area of expression, %)	EGF (relative area of expression, %)	TGF-β1 (relative area of expression, %)
Women with androgenic alopecia (n=15)	32.24 (30.59; 33.83)*	22.32 (21.93; 23.81)*	20.96 (20.12; 21.7)	56.11 ± 1.77*
Healthy women (n=8)	68.53 ± 1.08	47.68 ± 0.93	19.96 ± 3	51.72 ± 2.21

The Study of Growth Factors in Patients with Androgenic Alopecia

Introduction Hair follicles develop from ectodermal and mesenchymal cells. The first morphological feature of follicles formation is the appearance of thickenings in epidermis, so-called “placodes”, located at equal distances. Placode formation begins with local bulge of epithelium and the as

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Growth factor Trial groups	VEGF (relative area of expression, %)	KGF (relative area of expression, %)	EGF (relative area of expression, %)	TGF-β1 (relative area of expression, %)
Men with androgenic alopecia (n=15)	56.27 ± 1.36*	61.33 ± 1.01*	65.05 ± 2.49*	82.38 ± 1.05*
Healthy men (n=8)	66.53 ± 1.42	49.76 ± 1.31	22.56 ± 0.5	54.45 ± 0.59

 

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Expression of the VEGF, KGF, EGF, and TGF-β1 growth factors is impaired in patients with androgenic alopecia in comparison with healthy persons. The level of growth factors expression depends on the patient’s sex, age, duration and nature of the disease progression. Thus, we may conclude that the VEGF, KGF, TGF-β1 growth factors influence the development of androgenic alopecia in women. Men obviously have other factors prevailing in the pathogenesis of alopecia development