A recent study published in the April 8 issue of Nature Chemical Biology improves on the "Cellular Reprogramming" method developed by Nobel Laureate in Medicine and Physiology Prof. Shinya Yamanaka, making it possible to produce cells in a considerably shorter time and with greater success. Yamanaka's method, which is referred to as "Cellular Reprogramming," obtains pluripotent cells, similar to the ones we know exist in the very early stages of the embryo.Since such cells are obtained by transforming existing cells of the body (such as skin cells), they are referred to as induced pluripotent stem cells, or iPS in short.
While transformative and hugely important, Yamanaka's reprogramming method needed improvement in two regards. First of all, the transformation of cells takes a long time, around 3-4 weeks. And the rate of successful reprogramming was rather low: Around one in a hundred thousand.
Now, thanks to the joint work of Assoc. Prof. Tamer Önder of Koç University School of Medicine and doctoral students Ayyub Ebrahimi and Kenan Sevinç, along with Prof. Udo Oppermann of Oxford University and his team, this waiting period has shortened, and the success rate has increased.
https://phys.org/news/2019-06-era-stem-cell-therapy.html
Paper:
https://www.nature.com/articles/s41589-019-0264-z#Sec30
While transformative and hugely important, Yamanaka's reprogramming method needed improvement in two regards. First of all, the transformation of cells takes a long time, around 3-4 weeks. And the rate of successful reprogramming was rather low: Around one in a hundred thousand.
Now, thanks to the joint work of Assoc. Prof. Tamer Önder of Koç University School of Medicine and doctoral students Ayyub Ebrahimi and Kenan Sevinç, along with Prof. Udo Oppermann of Oxford University and his team, this waiting period has shortened, and the success rate has increased.
https://phys.org/news/2019-06-era-stem-cell-therapy.html
Paper:
https://www.nature.com/articles/s41589-019-0264-z#Sec30
