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o no lo entiendo bien o creo que los resultados de la fase 3 de kx826 no son muy alentadores.....
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The results of phase 3 pyrilutamide are already in
- Thread starter peladillo peach
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Dosent sound like a complete failure to me, their wording is confusing and potentially selective for their place in the stocks market but it sounds like they are saying essentially; It did help promote growth of the hair, where as the hair count wasn't different to placebo, however this could have been due to the vehicle, dosage or the subjects ability to stick to the protocol, I say this because of their wording " but a trend in efficacy was observed." which suggests that there was an issue in the delivery somehow which could have lead to the lack of hair count increases.
Also they are still active in continuing their trials and plan to proceed. These Phase 3 results look like the reason behind why they decided to add the extra trial in, many speculated that results along the lines of what they have announced here would be the reason for the additional trial and it looks like those predictors were correct. A huge piece to this though is the fact that there is still a good safety profile, which gives hope for this making it to commercialisation.
Will it be anything close to finasteride/dutasteride with its results, well now we can pretty much assume no. However it may be a nice addition for maintenance
Also they are still active in continuing their trials and plan to proceed. These Phase 3 results look like the reason behind why they decided to add the extra trial in, many speculated that results along the lines of what they have announced here would be the reason for the additional trial and it looks like those predictors were correct. A huge piece to this though is the fact that there is still a good safety profile, which gives hope for this making it to commercialisation.
Will it be anything close to finasteride/dutasteride with its results, well now we can pretty much assume no. However it may be a nice addition for maintenance
Daym thats pretty devastating for those of us who were banking on this stuff. What I would say is though that the placebo apparently had gains in TAHC so that makes it all a little weird as the non placebo may actually have helped with maintenance"Trend in efficacy" just means that it probably helped, but it did not do enough to reach statistical significance. It's pharmaspeak for cope.
I tried pyriltamide bought from anagenica, in theory 98% pure pyri, and it stopped my hairloss in 1-2 weeks. The best hair treatment that I ever tried, honestly.
But it killed my libido at week 4-5 in a super strong way, much more than finasteride. Literally in had no dick. Also I lost 3 kg (even going to the gym 2-3 times per week), I was always tired and sleepy and my heart rhythm was irregular.
If I didn’t stop the treatment I would be death.
But it killed my libido at week 4-5 in a super strong way, much more than finasteride. Literally in had no dick. Also I lost 3 kg (even going to the gym 2-3 times per week), I was always tired and sleepy and my heart rhythm was irregular.
If I didn’t stop the treatment I would be death.
Either you're a hypochondriac, or what you got was not pyrilutamideI tried pyriltamide bought from anagenica, in theory 98% pure pyri, and it stopped my hairloss in 1-2 weeks. The best hair treatment that I ever tried, honestly.
But it killed my libido at week 4-5 in a super strong way, much more than finasteride. Literally in had no dick. Also I lost 3 kg (even going to the gym 2-3 times per week), I was always tired and sleepy and my heart rhythm was irregular.
If I didn’t stop the treatment I would be death.
Not hypochondriac. Do you think anagenic was selling fake Pyri?Either you're a hypochondriac, or what you got was not pyrilutamide
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If the report makes anything clear, it is that no adverse effects were reported, that is the good thing... the bad thing is that it is just as effective as pouring tap water.
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Finasteride and dutasteride inhibit the AR more potently than pyrilutamide. It could be worth a shot as a combination therapy with dutasteride, but RU58841 is probably better.But it did grow hair? Or even maintained? So for people who finasteride or dutasteride has not worked for - and I am continuing to lose on dutasteride - this could be worth a shot?
Finasteride and dutasteride inhibit the AR more potently than pyrilutamide. It could be worth a shot as a combination therapy with dutasteride, but RU58841 is probably better.
RU probably maxed-out the possibilities of fighting androgen exposure, and did it decades ago. I doubt anything else will ever match/beat it without having real systemic effect problems.
supermusic
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ru has been on the gray market for quite a few years now, many people have tried it but I have seen few cases with photos showing visible progress or improvement. So in my opinion it doesn't help much either.RU probably maxed-out the possibilities of fighting androgen exposure, and did it decades ago. I doubt anything else will ever match/beat it without having real systemic effect problems.
ru has been on the gray market for quite a few years now, many people have tried it but I have seen few cases with photos showing visible progress or improvement. So in my opinion it doesn't help much either.
It's coming from bootleg sources, some batches failed tests, the drug has known stability problems even when it's made correctly, and the method-of-action is loss prevention more than regrowth. The gray market feedback is probably not that reliable.
The various RU clinical trails pointed to results similar to oral Finasteride. That makes sense to me. If Finasteride was only known as a bootleg drug from inconsistent sources then we probably wouldn't hear too much glowing feedback about it either.
That whole route to fighting hair loss is a dead end. We've seen what blocking androgen exposure can do and it's not very much.
Do you have a source for the known stability problems? I have heard this a few times, but have never seen any source. It doesn't make sense to trial a hair loss drug that is not stable on the shelf for at least one yearIt's coming from bootleg sources, some batches failed tests, the drug has known stability problems even when it's made correctly, and the method-of-action is loss prevention more than regrowth. The gray market feedback is probably not that reliable.
The various RU clinical trails pointed to results similar to oral Finasteride. That makes sense to me. If Finasteride was only known as a bootleg drug from inconsistent sources then we probably wouldn't hear too much glowing feedback about it either.
That whole route to fighting hair loss is a dead end. We've seen what blocking androgen exposure can do and it's not very much.
These results of Pyrilutamide are written in a vague way. The data analysis showed that KX-826 promoted hair growth compared to baseline and demonstrated statistical and clinically meaningful as measured by target area non-vellus hair count (TAHC
So it promoted hair growth.
I have a bottle of it so am testing it.
It has almost same chemical structure as RU but a longer half life. Which means it works longer. Both are androgen receptor antagonists.
Minoxidil in a Petrie dish grows hairs 16 times more than placebo. But most of us know it often doesn’t do anything for us.. though until we get something better it will be used.
I like Pyrilurmtamide in conjunction w) other products & will continue to use it.
So it promoted hair growth.
I have a bottle of it so am testing it.
It has almost same chemical structure as RU but a longer half life. Which means it works longer. Both are androgen receptor antagonists.
Minoxidil in a Petrie dish grows hairs 16 times more than placebo. But most of us know it often doesn’t do anything for us.. though until we get something better it will be used.
I like Pyrilurmtamide in conjunction w) other products & will continue to use it.