So I heard that Setipiprant failed the trials for hair loss, as well as allergies and asthma. In short, the CRTH2 blockade didn't do sh*t.
However, Ramatroban, another CRTH2 antagonist, DOES work for allergies:
http://www.ncbi.nlm.nih.gov/m/pubmed/11778458/
In my opinion, Setipiprant is just a sh*t drug and too weak to stop hair loss.
If trials on hair loss were conducted on TM30089, a chemical analogue of Ramatroban that is far more potent with INSURMOUNTABLE blockade to the receptor, meaning it doesn't let any PGD2 bind to the receptor at all, I have a feeling we would have much better results.
I personally take it orally, 1 - 3mg a day (yes it's THAT potent) and it's certainly reduced, if not entirely stopped itch and shedding. No side effects. I've experimented with up to 10mg a day for months at a time, no side effects. Some fearmongers were spreading hysteria about it having a half life of like a million years; I notice return of itch after a few days cessation.
I read a post of someone who took it topically at 0.1% once a day, and claimed it did way better than RU at 5%.
However, Ramatroban, another CRTH2 antagonist, DOES work for allergies:
http://www.ncbi.nlm.nih.gov/m/pubmed/11778458/
In my opinion, Setipiprant is just a sh*t drug and too weak to stop hair loss.
If trials on hair loss were conducted on TM30089, a chemical analogue of Ramatroban that is far more potent with INSURMOUNTABLE blockade to the receptor, meaning it doesn't let any PGD2 bind to the receptor at all, I have a feeling we would have much better results.
I personally take it orally, 1 - 3mg a day (yes it's THAT potent) and it's certainly reduced, if not entirely stopped itch and shedding. No side effects. I've experimented with up to 10mg a day for months at a time, no side effects. Some fearmongers were spreading hysteria about it having a half life of like a million years; I notice return of itch after a few days cessation.
I read a post of someone who took it topically at 0.1% once a day, and claimed it did way better than RU at 5%.
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