The link between chronic caffeine intake an increased androgenic sensitivity
- Thread starter Nebula74
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I think rat studies mislead. Apparently male rats are hairier than the female ones and this has led to wrong-thinking about estrogen not improving hair and even promoting hair loss. Nope. Anyway, studies where they actually shave rats and then see if various things make the fur grow back faster are relevant and that's where the use of polysorbates started in hair loss. It was an accident though like minoxidil and we don't know why either works although as topicals, they are mostly for maintenance. Then some dude somewhere drank his minoxidil and was like, "wow" but I am not telling anyone. I am puzzled why females have been using low dose oral minoxidil for years and as to why it took Upjohn/males essentially 40 years to figure out that oral minoxidil works far better but sometimes it takes information and studies many years to sink into the public consciousness but I digress.
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Thanks for that. Even at my age, the minoxidil emergence and testing by Upjohn was before me and the public had far less access to potential treatments and knew little about different ingestion methods and we often still don't.
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2008:
www.ncbi.nlm.nih.gov
2013:
[...]
The caffeine in a cup of coffee might help your small blood vessels work better, according to research presented at the American Heart Association's Scientific Sessions 2013.
A study of 27 healthy adults showed -- for the first time -- that drinking a cup of caffeinated coffee significantly improved blood flow in a finger, which is a measure of how well the inner lining of the body's smaller blood vessels work. Specifically, participants who drank a cup of caffeinated coffee had a 30 percent increase in blood flow over a 75-minute period compared to those who drank decaffeinated coffee.'
'Caffeine Stimulation of Cortisol Secretion Across the Waking Hours in Relation to Caffeine Intake Levels
[...]Conclusion
Cortisol responses to caffeine are reduced, but not eliminated, in healthy young men and women who consume caffeine on a daily basis.'
Caffeine Stimulation of Cortisol Secretion Across the Waking Hours in Relation to Caffeine Intake Levels
Caffeine increases cortisol secretion in people at rest or undergoing mental stress. It is not known whether tolerance develops in this response with daily intake of caffeine in the diet. We therefore tested the cortisol response to caffeine challenge ...
www.ncbi.nlm.nih.gov
2013:
'Coffee may help perk up your blood vessels
[...]
The caffeine in a cup of coffee might help your small blood vessels work better, according to research presented at the American Heart Association's Scientific Sessions 2013.
A study of 27 healthy adults showed -- for the first time -- that drinking a cup of caffeinated coffee significantly improved blood flow in a finger, which is a measure of how well the inner lining of the body's smaller blood vessels work. Specifically, participants who drank a cup of caffeinated coffee had a 30 percent increase in blood flow over a 75-minute period compared to those who drank decaffeinated coffee.'
Coffee may help perk up your blood vessels
A small study showed that a cup of coffee improved small blood vessel function. The study takes us one step closer to understanding how coffee might benefit cardiovascular health.
www.sciencedaily.com
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So ?
Caffeine intake drives down iron absorption so that could be a reason for oral hair loss from it.
pubmed.ncbi.nlm.nih.gov
Results: Increased smoking duration (p < 0.001) and the presence of dandruff (p = 0.028) were significantly associated with increased frontal hair loss
Increased exercise duration (p = 0.002), consumption of more than four alcoholic drinks per week (p = 0.042), and increased money spent on hair loss products (p = 0.050) were all associated with increased temporal hair loss.
Daily hat use (p = 0.050), higher body mass index (p = 0.012), and higher testosterone levels (p = 0.040) were associated with decreased temporal hair loss.
Factors that were significantly associated with increased vertex hair loss included abstinence from alcohol consumption (p = 0.030), consumption of more than four alcoholic drinks per week (p = 0.004), increased smoking duration (p = 0.047), increased exercise duration (p = 0.050), and increased stress duration (p = 0.010). Lower body mass index, more children, increased caffeine consumption, history of skin disease, and abstinence from alcohol were significantly associated with increased hair thinning scores (p < 0.05).
Conclusion: This study offers substantial evidence that exogenous factors may have a clinically significant impact on hair loss.
pubmed.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
Restore iron with lactoferrin and not ferrous sulfate. Lactoferrin scavenges excess iron too which it is easy to OD on. Notice in the below study ferrous sulfate increased serum IL-6 and lactoferrin did not.
pubmed.ncbi.nlm.nih.gov
www.frontiersin.org
One of the most well-known characteristics of LF is that it is antibacterial (19, 144–148), antiviral (99, 149–151), antifungal (152–154), anti-inflammatory (26), and anti-carcinogenic (155). Its ability to of limit iron availability to microbes is one of its crucial amicrobial properties. Bacteria have, however, developed various ways to sequester iron (156). Figure 4 shows how bacteria acquire iron through receptor-mediated recognition of transferrin, hemopexin, hemoglobin, or hemoglobin-haptoglobin complexes and also LF (30). As well as binding it directly from the environment, bacterial siderophores can obtain iron by removing it from transferrin, lactoferrin, or ferritin
Enteric coating allows LF release some distance from LF-degrading pepsin activities in the stomach, allowing it to remain intact, in the form capable of binding small intestinal LF receptors for uptake and eventual transfer into the systemic circulation (182). In a rodent study, the “absorption” of enteric-formulated LF was approximately 10-fold higher than that of regular LF introduced into the stomach of experimental animals (128). In view of these investigations, the authors of this paper regard enteric-coated LF as superior to regular LF supplements with respect to bioavailability and potential application for the prevention or therapy for coronaviruses such as the SARS-Cov-2 involved in COVID-19.
Bacteria are warring with us in our guts trying to take our iron.
Although LF has various means to counteract bacteria as part of its immune function (131), it is also capable of being hijacked to benefit the activities of bacteria. Thus, bacteria can also exploit LF by removing its bound ferric iron (19, 30). This process involves (1) synthesis of high-affinity ferric ion chelators by bacteria, (2) iron acquisition through LF or transferrin binding, mediated by bacterial-specific surface bacterial receptors, (3) or iron acquisition through bacterial reductases, which are able to reduce ferric to ferrous ions (19, 144–148).
Several Gram-negative pathogens including members of the genera Neisseria and Moraxella have evolved two-component systems that can extract iron from the host LF and transferrin (157). N. meningitidis is a principal cause of bacterial meningitis in children. While the majority of pathogenic bacteria employ siderophores to chelate and scavenge iron
It is fairly well established that male pattern baldness is a low grade systemic disease too which depletes iron even further AKA "anemia of inflammation"
www.ncbi.nlm.nih.gov
www.verywellhealth.com
Their research, published in a July 16 report in Nature Communications, found that the genes involved in metabolizing iron in the blood are connected to longer, healthier lives.1
In addition, abnormally high or low levels of blood iron can lead to age-related health conditions, like liver disease, Parkinson’s disease, and a decreased ability to fight off infection.
"It appears that humans become less effective at incorporating iron into red blood cells as we get older," Kalea Wattles, ND, a naturopathic physician and clinical content coordinator at the Institute for Functional Medicine, tells Verywell.
Wattles says that, as a result, more iron is left behind to create something called free radicals.
pubmed.ncbi.nlm.nih.gov
Conclusions: These findings suggest that OSA may be a risk factor for male pattern baldness in men who have a family history of hair loss and that low serum TSA(serum transferrin saturation) levels associated with hypoxia may be involved in a pathway linking OSA and male pattern baldness.
I will add about erythrocyte sedimentation rate and male pattern baldness later....
The contribution of endogenous and exogenous factors to male alopecia: a study of identical twins - PubMed
Risk, III.
pubmed.ncbi.nlm.nih.gov
Results: Increased smoking duration (p < 0.001) and the presence of dandruff (p = 0.028) were significantly associated with increased frontal hair loss
Increased exercise duration (p = 0.002), consumption of more than four alcoholic drinks per week (p = 0.042), and increased money spent on hair loss products (p = 0.050) were all associated with increased temporal hair loss.
Daily hat use (p = 0.050), higher body mass index (p = 0.012), and higher testosterone levels (p = 0.040) were associated with decreased temporal hair loss.
Factors that were significantly associated with increased vertex hair loss included abstinence from alcohol consumption (p = 0.030), consumption of more than four alcoholic drinks per week (p = 0.004), increased smoking duration (p = 0.047), increased exercise duration (p = 0.050), and increased stress duration (p = 0.010). Lower body mass index, more children, increased caffeine consumption, history of skin disease, and abstinence from alcohol were significantly associated with increased hair thinning scores (p < 0.05).
Conclusion: This study offers substantial evidence that exogenous factors may have a clinically significant impact on hair loss.
Inhibition of food iron absorption by coffee - PubMed
Dual isotope studies were performed in iron replete human subjects to evaluate the effect of coffee on nonheme iron absorption. A cup of coffee reduced iron absorption from a hamburger meal by 39% as compared to a 64% decrease with tea, which is known to be a potent inhibitor of iron absorption...
pubmed.ncbi.nlm.nih.gov
Association of Coffee and Tea with Ferritin: Data from the Korean National Health and Nutrition Examination Survey (IV and V)
There have been few studies that have evaluated the association between coffee intake and iron in Korean population. Data from the Korean National Health and Nutrition Examination Survey (IV and V; 2007–2012) was used to investigate the association ...
www.ncbi.nlm.nih.gov
Iron Plays a Certain Role in Patterned Hair Loss
Role of iron in hair loss is not clear yet. The purpose of this study was to evaluate the relationship between iron and hair loss. Retrospective chart review was conducted on patients with female pattern hair loss (FPHL) and male pattern hair loss (MPHL). ...
www.ncbi.nlm.nih.gov
Restore iron with lactoferrin and not ferrous sulfate. Lactoferrin scavenges excess iron too which it is easy to OD on. Notice in the below study ferrous sulfate increased serum IL-6 and lactoferrin did not.
Lactoferrin efficacy versus ferrous sulfate in curing iron disorders in pregnant and non-pregnant women - PubMed
Iron homeostasis in pregnancy compensates for increased iron requirements and in women of child-bearing age for iron loss in menses. Oral administration of ferrous sulfate, prescribed to cure iron deficiency (ID) and ID anemia (IDA), often fails to increase hematological parameters and causes...
pubmed.ncbi.nlm.nih.gov
Frontiers | The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria
<p>Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred via a variety of receptors into and between cells, serum, ...
www.frontiersin.org
One of the most well-known characteristics of LF is that it is antibacterial (19, 144–148), antiviral (99, 149–151), antifungal (152–154), anti-inflammatory (26), and anti-carcinogenic (155). Its ability to of limit iron availability to microbes is one of its crucial amicrobial properties. Bacteria have, however, developed various ways to sequester iron (156). Figure 4 shows how bacteria acquire iron through receptor-mediated recognition of transferrin, hemopexin, hemoglobin, or hemoglobin-haptoglobin complexes and also LF (30). As well as binding it directly from the environment, bacterial siderophores can obtain iron by removing it from transferrin, lactoferrin, or ferritin
Enteric coating allows LF release some distance from LF-degrading pepsin activities in the stomach, allowing it to remain intact, in the form capable of binding small intestinal LF receptors for uptake and eventual transfer into the systemic circulation (182). In a rodent study, the “absorption” of enteric-formulated LF was approximately 10-fold higher than that of regular LF introduced into the stomach of experimental animals (128). In view of these investigations, the authors of this paper regard enteric-coated LF as superior to regular LF supplements with respect to bioavailability and potential application for the prevention or therapy for coronaviruses such as the SARS-Cov-2 involved in COVID-19.
Bacteria are warring with us in our guts trying to take our iron.
Although LF has various means to counteract bacteria as part of its immune function (131), it is also capable of being hijacked to benefit the activities of bacteria. Thus, bacteria can also exploit LF by removing its bound ferric iron (19, 30). This process involves (1) synthesis of high-affinity ferric ion chelators by bacteria, (2) iron acquisition through LF or transferrin binding, mediated by bacterial-specific surface bacterial receptors, (3) or iron acquisition through bacterial reductases, which are able to reduce ferric to ferrous ions (19, 144–148).
Several Gram-negative pathogens including members of the genera Neisseria and Moraxella have evolved two-component systems that can extract iron from the host LF and transferrin (157). N. meningitidis is a principal cause of bacterial meningitis in children. While the majority of pathogenic bacteria employ siderophores to chelate and scavenge iron
It is fairly well established that male pattern baldness is a low grade systemic disease too which depletes iron even further AKA "anemia of inflammation"
Anemia of Inflammation
Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic normochromic anemia that is caused by an underlying inflammatory disease. It is diagnosed when serum iron concentrations are low despite adequate iron ...
www.ncbi.nlm.nih.gov
Blood Iron Levels May Be Key to Healthy Aging
Learn more about how the iron in your blood is associated with better aging and how to keep your levels within optimal ranges.
Their research, published in a July 16 report in Nature Communications, found that the genes involved in metabolizing iron in the blood are connected to longer, healthier lives.1
In addition, abnormally high or low levels of blood iron can lead to age-related health conditions, like liver disease, Parkinson’s disease, and a decreased ability to fight off infection.
"It appears that humans become less effective at incorporating iron into red blood cells as we get older," Kalea Wattles, ND, a naturopathic physician and clinical content coordinator at the Institute for Functional Medicine, tells Verywell.
Wattles says that, as a result, more iron is left behind to create something called free radicals.
Obstructive sleep apnea, low transferrin saturation levels, and male-pattern baldness - PubMed
These findings suggest that OSA may be a risk factor for male pattern baldness in men who have a family history of hair loss and that low serum TSA levels associated with hypoxia may be involved in a pathway linking OSA and male pattern baldness.
pubmed.ncbi.nlm.nih.gov
Conclusions: These findings suggest that OSA may be a risk factor for male pattern baldness in men who have a family history of hair loss and that low serum TSA(serum transferrin saturation) levels associated with hypoxia may be involved in a pathway linking OSA and male pattern baldness.
I will add about erythrocyte sedimentation rate and male pattern baldness later....
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So I loose my hair because I dont drink alkohol?
Yes...it apparently is a factor. Moderate alcohol consumption is also associated with longevity so there is something to it.
What % of a factor is it? IDK...10%ish(pure guess) but not the most important one like androgens of course.
________________________________________
Surprising Ways Alcohol May Be Good for You
That glass of wine with dinner might do more for you than take the edge off a long day. Check out these possible health benefits of drinking in moderation by clicking through the WebMD slideshow.
"If you're in good shape, moderate drinking makes you 25% to 40% less likely to have a heart attack, stroke, or hardened arteries. This may be in part because small amounts of alcohol can raise your HDL ("good" cholesterol) levels. Heavy drinking, on the other hand, boosts your risk of heart disease."
____________________________________________
Hardened arteries mean they don't dampen out the blood pressure pulses from the heart and the delicate capillaries(like in the scalp) take the blunt of it.
99% of our circulation is in the capillaries.
im gonna become a drunk
Not quite that far...but I do know a few who are not cheating themselves of alcohol intake and have NW0 hair lines and in their 50's and zero gray.
Moderate drinking helps keep arteries clean: study
Moderate consumption of alcohol can stop, and maybe even reduce, the buildup of fat in arteries that is the leading cause of heart disease, according to a new study.
www.theglobeandmail.com
Alcohol’s Effects on the Cardiovascular System
Alcohol use has complex effects on cardiovascular (CV) health. The associations between drinking and CV diseases such as hypertension, coronary heart disease, stroke, peripheral arterial disease, and cardiomyopathy have been studied extensively and are ...
www.ncbi.nlm.nih.gov
Mechanisms Related to Alcohol’s Positive and Adverse Effects on CV Conditions
Many of the CV conditions outlined above share the pathophysiologic process of atherosclerosis and inflammation. Therefore, alcohol may exert its protective or enhancing effects on these conditions by modifying three broad categories of mechanisms: risk factors (e.g., lipid profiles, carotid intima-medial thickness [cIMT], and insulin sensitivity), hemostatic factors (e.g., fibrinogen levels and platelet reactivity), and inflammation. In addition, and specific to CHD, alcohol consumption may modulate ischemia–reperfusion mechanisms as blood flow is restored to tissues after oxygen deprivation. Several of these potential mechanisms are briefly reviewed below.
One Drink Of Red Wine Or Alcohol Is Relaxing To Circulation, But Two Drinks Are Stressful
One drink of either red wine or alcohol slightly benefits the heart and blood vessels, but the positive effects on specific biological markers disappear with two drinks, say researchers. Researchers conducted a real-time study of thirteen volunteers to determine whether a red wine with a...
www.sciencedaily.com
BPH is another androgen driven disease and....
Compared to no alcohol intake, an alcohol intake of 36 gm daily or greater was associated with a 35% decreased likelihood of benign prostatic hyperplasia (OR 0.65, 95% CI 0.58 – 0.74, p 0.001). Of the 4 studies that used lower urinary tract symptoms as the primary outcome 3 demonstrated a significantly increased likelihood of lower urinary tract symptoms with alcohol consumption. Conclusions: Alcohol consumption is associated with a decreased likelihood of benign prostatic hyperplasia but not of lower urinary tract symptoms. Further studies are needed to determine the mechanisms by which alcohol modifies the risk of benign prostatic hyperplasia
The metabolic syndrome is associated with systemic inflammation and oxidative stress,29 and histological BPH consistently occurs with inflammation.30 Thus, it is possible that metabolic disturbances promote microvascular disease and inflammation, which in turn contribute to ischemia, oxidative stress and an intraprostatic environment favorable to BPH. It is also possible that alcohol intake may modulate BPH through alterations in sympathetic tone.
How many grams of alcohol in a 12 oz(5%) beer.....14 grams.
What Is A Standard Drink? | National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Many people are surprised to learn what counts as a drink. The amount of liquid in your glass, can, or bottle does not necessarily match up to how much alcohol is actually in your drink. Different types of beer, wine, or malt liquor can have very different amounts of alcohol content. For...
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- Reaction score
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apply topical white claw to avoid systemic effects
Why is your name poop feast?
- Reaction score
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My parents named me after my grandfather.
Full of sh*t
- Reaction score
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yo I finally found out why I'm losing my hair then!!11`11`1`121
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- 348
I drink four of these every day. Two in the morning and two in the evening
Well if you swapped it for whiskey you'd be NW0
- Reaction score
- 348
alcohol sucks ngl
No wonder the homeless guys are all NW0