OverMachoGrande
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The "Big Three" Diseases Associated With M.P.B.
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OverMachoGrande
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Bryan said:[
LOL!! Is THAT the best you can do, to try to explain why reducing estrogen for YEARS with an aromatase inhibitor doesn't affect BPH or hairloss?
Because it's stuck to S.H.B.G. what don't you understand about that? Inhibit aromatase all ya want, it's not gunna displace estrogen from S.H.B.G.
OverMachoGrande
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Bryan said:LOL!! Is THAT the best you can do, to try to explain why reducing estrogen for YEARS with an aromatase inhibitor doesn't affect BPH or hairloss?
Because it's stuck to S.H.B.G. what don't you understand about that? Inhibit aromatase all ya want, it's not gunna displace estrogen from S.H.B.G.
OverMachoGrande
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Bryan said:
Don't you think this is worth investigating?
I believe that S.H.B.G. transports sex hormones to the receptor. The receptor being the S.H.B.G.-receptor.
Like another poster posted on my S.H.B.G. forum...he said that sex hormone binding globulin is like a taxi cab that picks up sex hormones and drives them to their specific location or destination.
It's complete nonsense to think that S.H.B.G. binds to hormones and "deactivates" them or renders them useless, because S.H.B.G. has a receptor! It seems to me that D.H.T., estradiol, and testosterone all compete for the same receptor...that receptor being S.H.B.G., which then binds to a receptor of it's own.
This also explains why an aromatase inhibitor or an alpha-5-reductase inhibitor has very little effect of hair growth, it's because you are inhibiting further production of D.H.T. or estradiol but not dealing with the D.H.T. or estradiol that is all ready bound to S.H.B.G., which is bound to the sex hormone binding globulin-receptor!
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misterE said:
No.
misterE said:
I'm telling you that that's ONLY in the prostate. For the THIRD TIME now, I'm telling you to stop wasting your time in a fruitless effort to try to make everybody think that the same thing happens in hair follicle cells.
OverMachoGrande
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OverMachoGrande
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Bryan said:
Why?
Bryan said:
Why would this ONLY happen in the prostate? This also explains acne, breast cancer, and male pattern baldness...all of which are hormonal related diseases.
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misterE said:
I don't know why the genetics and functions of prostates are different from the genetics and functions of hair follicles. Nobody does. That's like asking why hair follicles respond to androgens in a different fashion, depending on body location. Stop asking pointless questions that nobody can answer.
misterE said:
No it doesn't. You're a perfect example of that old saying, "A little knowledge is a dangerous thing." You take little things you read about on Google and PubMed (in this case, things having to do with the prostate), and try to EXTEND that to other things like hair follicles and sebaceous glands. But that's a fool's game! You're simply showing your appalling ignorance by trying to make everybody believe that everything that happens in the prostate also happens in hair follicles!
OverMachoGrande
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Brayn, you are getting defensive because you know in your heart (if ya got one) that I'm right (or on the right path), but your hidden agenda prohibits you from saying so.
By the way...you didn't answer my question. Why don't you think the sex-hormone-binding-globulin-receptor is worth investigating?
By the way...you didn't answer my question. Why don't you think the sex-hormone-binding-globulin-receptor is worth investigating?
OverMachoGrande
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Bryan said:
Then how do androgens cause baldness if there is no receptor?
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There are the normal INTRACELLULAR androgen receptors, doofus, but not the SHBG-rSHBG receptor complexes you like to talk about so much that bind to the outer membrane of prostate cells and imitate the function of androgen receptors. Do I have to explain every little thing to you, or did you really not understand what I was referring to?? :smack:
OverMachoGrande
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The androgen receptor and estrogen receptor are located on S.H.B.G. they are called ligand binding sites.
D.H.T. binds to the androgen receptor 3 times more than testosterone.
D.H.T. binds to the S.H.B.G. 3 times more than testosterone.
The androgen/estrogen receptor is S.H.B.G.
S.H.B.G. is a receptor that has a receptor.
D.H.T. binds to the androgen receptor 3 times more than testosterone.
D.H.T. binds to the S.H.B.G. 3 times more than testosterone.
The androgen/estrogen receptor is S.H.B.G.
S.H.B.G. is a receptor that has a receptor.
Bryan, you often say that the DHT made in the hair follicle plays a more prominent role in male pattern baldness than serum DHT which I agree tend to agree with. Is the 5ar enzyme that converts testosterone to DHT present within each follicle cell?
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baller234 said:
Yes, and it is ONLY located within cells (not just hair follicle cells, but also prostate cells, liver cells, sebaceous gland cells, etc.). I've seen people make the erroneous assumption that the enzyme circulates in the bloodstream, but that's completely false. It stays inside cells, tightly bound to certain cellular membranes (some say the nuclear membrane, some say the membrane of the endoplasmic reticulum).
What's really interesting is that 5a-reductase is SOOOO tightly bound to internal cellular membranes, scientists still have a hard time getting it out! I've read that they STILL don't have significant external supplies of it on hand, for that very reason; for example, you can't just walk into a biochemical laboratory and ask for a bottle of 5a-reductase!
