so after all this time fighting hairloss and the many treatments, i now see it clearly.
we could win this battle!
as you know people got good results from finasteride+minoxidil and keto shampoo, but this isn't enough.
people are using anti androgens like ru instead of propecia and get results even better than propeica, but we need to think outside the box to realy win this battle.
after tons of reading i think there is still a lot of bullets in our arsenal.
one of them is ru-myristate.
it is prodrug of regular ru58841, with all the benefits with lower doese and without side effects.
i checked and in the past some people tried it, but without the vehicle they realy need.
they clearly didn't use it properly, and it is sad to drop something like this becasue some wrong directions.
Acne and androgenetic alopecia are linked to androgen effects and therefore should improve following topical application of antiandrogens. We present a new antiandrogen prodrug, RU 58841-myristate (RUM) for topical therapy. Almost devoid of affinity to the androgen receptor, as derived from investigations in the mouse fibroblast cell line 29 +/GR +, RUM is rapidly metabolised to the potent antiandrogen RU 58841 by cultured human foreskin fibroblasts and keratinocytes, male occipital scalp skin dermal papilla cells, and by cells of the sebaceous gland cell line SZ95. In order to improve a specific targeting of the hair follicle, RUM was loaded on solid lipid nanoparticles (SLN), which are already known to support dermal targeting effects. Physically stable RUM loaded SLN were produced by hot homogenization. Penetration/permeation studies carried out using the Franz diffusion cell proved only negligible permeation of reconstructed epidermis and excised porcine skin within 6 h, implying a more topical action of the drug. Targeting to the hair follicle using SLN was visualised by fluorescence microscopy, following the application of Nile Red labelled SLN to human scalp skin. Transmission electron microscopy (TEM) allowed to detect intact silver labelled SLN in porcine hair follicles of preparations applied to the skin for 24 h. RUM loaded SLN should be considered for topical antiandrogen therapy of acne and androgenetic alopecia.
it looks realy interesting and promising and for the people among us who are using regular ru , it could save money and side effects, remeber you need less of it and it will go to where it should in the scalp and not other unwanted places.
we could win this battle!
as you know people got good results from finasteride+minoxidil and keto shampoo, but this isn't enough.
people are using anti androgens like ru instead of propecia and get results even better than propeica, but we need to think outside the box to realy win this battle.
after tons of reading i think there is still a lot of bullets in our arsenal.
one of them is ru-myristate.
it is prodrug of regular ru58841, with all the benefits with lower doese and without side effects.
i checked and in the past some people tried it, but without the vehicle they realy need.
they clearly didn't use it properly, and it is sad to drop something like this becasue some wrong directions.
Acne and androgenetic alopecia are linked to androgen effects and therefore should improve following topical application of antiandrogens. We present a new antiandrogen prodrug, RU 58841-myristate (RUM) for topical therapy. Almost devoid of affinity to the androgen receptor, as derived from investigations in the mouse fibroblast cell line 29 +/GR +, RUM is rapidly metabolised to the potent antiandrogen RU 58841 by cultured human foreskin fibroblasts and keratinocytes, male occipital scalp skin dermal papilla cells, and by cells of the sebaceous gland cell line SZ95. In order to improve a specific targeting of the hair follicle, RUM was loaded on solid lipid nanoparticles (SLN), which are already known to support dermal targeting effects. Physically stable RUM loaded SLN were produced by hot homogenization. Penetration/permeation studies carried out using the Franz diffusion cell proved only negligible permeation of reconstructed epidermis and excised porcine skin within 6 h, implying a more topical action of the drug. Targeting to the hair follicle using SLN was visualised by fluorescence microscopy, following the application of Nile Red labelled SLN to human scalp skin. Transmission electron microscopy (TEM) allowed to detect intact silver labelled SLN in porcine hair follicles of preparations applied to the skin for 24 h. RUM loaded SLN should be considered for topical antiandrogen therapy of acne and androgenetic alopecia.
it looks realy interesting and promising and for the people among us who are using regular ru , it could save money and side effects, remeber you need less of it and it will go to where it should in the scalp and not other unwanted places.
