The Gardener
Senior Member
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Tynan told me.
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the best and safest?
- Thread starter Spaade777
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michael barry
Senior Member
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Here is a new study about how exactly minoxidil works, read and learn young'un's.
Hair growth effect of minoxidil]
[Article in Japanese]
Otomo S.
Pharmacological Evaluation Laboratory, Taisho Pharmaceutical Co., Ltd., 403, Yoshino-cho 1-chome, Saitama-shi, Saitama 330-8530, Japan.
The length and size of hair are depend on the anagen term in its hair cycle. It has been reported that the some cell growth factors, such as VEGF, FGF-5S, IGF-1 and KGF, induce the proliferation of cells in the matrix, dermal papilla and dermal papillary vascular system and increase the amount of extra cellular matrix in dermal papilla and then maintain follicles in the anagen phase. On the other hand, negative factors, like FGF-5, thrombospondin, or still unknown ones, terminate the anagen phase. If the negative factors become dominant against cell proliferation factors according to fulfilling some time set by the biological clock for hair follicles, TGF beta induced in the matrix tissues evokes apoptosis of matrix cells and shifts the follicles from anagen to catagen. Androgenetic alopecia is caused by miniaturizing of hair follicles located in the frontal or crown part of scalp and are hereditarily more sensitive to androgen. In their hair cycles, the androgen shortens the anagen phase of follicles and shifts them to the catagen phase earlier than usual. The mode of action of hair growth effect of minoxidil is not completely elucidated, but the most plausible explanation proposed here is that minoxidil works as a sulfonylurea receptor (SUR) activator and prolongs the anagen phase of hair follicles in the following manner: minoxidil (1) induces cell growth factors such as VEGF, HGF, IGF-1 and potentiates HGF and IGF-1 actions by the activation of uncoupled SUR on the plasma membrane of dermal papilla cells, (2) inhibits of TGF beta induced apoptosis of hair matrix cells by opening the Kir 6.0 channel pore coupled with SUR on the mitochondrial inner membrane, and (3) dilates hair follicle arteries and increases blood flow in dermal papilla by opening the Kir 6.0 channel pore coupled with SUR on the plasma membrane of vascular smooth muscle cells
As you can see, there is much more to minoxidil that just "growth stimulant"
In baldness, DHT binds to a receptor and then the dermal papilla cells release growth inhibitors like FGF-5 and thrombospondin, and others.................one of these negative growth factors probably elicits and immuno resonse towards the struggling follicle. We know that TGF beta probably gets the fibroblasts to deposit collagen all around the struggling follicle and effectively make it hard for microcapillaries to reach it. minoxidil is the most effective stimulant we have and its super cheap (and you can make it yourself even cheaper).
A regimine that consists of finasteride, minoxidil, nizoral shampoo every other day, and topical spironolactone twice a day on days you dont use spironolactone should keep you in hair a long, long, while if youre just beginning to lose it. Adding a copper peptide product (dont use within thirty minutes of minoxidil) should add time further still.
REmember, we are waiting on cloning...........and when it comes you will keep THAT hair. Just hold on a few more years. It will almost certainly be availed within ten years at the most.
Hair growth effect of minoxidil]
[Article in Japanese]
Otomo S.
Pharmacological Evaluation Laboratory, Taisho Pharmaceutical Co., Ltd., 403, Yoshino-cho 1-chome, Saitama-shi, Saitama 330-8530, Japan.
The length and size of hair are depend on the anagen term in its hair cycle. It has been reported that the some cell growth factors, such as VEGF, FGF-5S, IGF-1 and KGF, induce the proliferation of cells in the matrix, dermal papilla and dermal papillary vascular system and increase the amount of extra cellular matrix in dermal papilla and then maintain follicles in the anagen phase. On the other hand, negative factors, like FGF-5, thrombospondin, or still unknown ones, terminate the anagen phase. If the negative factors become dominant against cell proliferation factors according to fulfilling some time set by the biological clock for hair follicles, TGF beta induced in the matrix tissues evokes apoptosis of matrix cells and shifts the follicles from anagen to catagen. Androgenetic alopecia is caused by miniaturizing of hair follicles located in the frontal or crown part of scalp and are hereditarily more sensitive to androgen. In their hair cycles, the androgen shortens the anagen phase of follicles and shifts them to the catagen phase earlier than usual. The mode of action of hair growth effect of minoxidil is not completely elucidated, but the most plausible explanation proposed here is that minoxidil works as a sulfonylurea receptor (SUR) activator and prolongs the anagen phase of hair follicles in the following manner: minoxidil (1) induces cell growth factors such as VEGF, HGF, IGF-1 and potentiates HGF and IGF-1 actions by the activation of uncoupled SUR on the plasma membrane of dermal papilla cells, (2) inhibits of TGF beta induced apoptosis of hair matrix cells by opening the Kir 6.0 channel pore coupled with SUR on the mitochondrial inner membrane, and (3) dilates hair follicle arteries and increases blood flow in dermal papilla by opening the Kir 6.0 channel pore coupled with SUR on the plasma membrane of vascular smooth muscle cells
As you can see, there is much more to minoxidil that just "growth stimulant"
In baldness, DHT binds to a receptor and then the dermal papilla cells release growth inhibitors like FGF-5 and thrombospondin, and others.................one of these negative growth factors probably elicits and immuno resonse towards the struggling follicle. We know that TGF beta probably gets the fibroblasts to deposit collagen all around the struggling follicle and effectively make it hard for microcapillaries to reach it. minoxidil is the most effective stimulant we have and its super cheap (and you can make it yourself even cheaper).
A regimine that consists of finasteride, minoxidil, nizoral shampoo every other day, and topical spironolactone twice a day on days you dont use spironolactone should keep you in hair a long, long, while if youre just beginning to lose it. Adding a copper peptide product (dont use within thirty minutes of minoxidil) should add time further still.
REmember, we are waiting on cloning...........and when it comes you will keep THAT hair. Just hold on a few more years. It will almost certainly be availed within ten years at the most.
I just wanted to say that its definitely not as simple as the ar-type2 enzyme. Plain and simple propecia is kind of a general barbaric blind stab in the dark at stopping hairloss. Its like radiation therapy to kill cancer its does some bad and some good. There is the estrogen/androgen ratio, tgf, inflammation, and probably some things no one even knows about yet all playing into hairloss which may be different types of hairloss just that no one can classify them yet.