Serpico
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There is older research that points out that black tea is a 5a-reductase inhibitor, so decreases DHT but increases testosterone (think of DHT as the highway exit, 5a-reductase as the construction that closes the exit, and testosterone as the cars that back up onto the interstate)
But that is old news.
Studies also pointed out that green tea increased testosterone, but no one knew how this related to its impact on DHT.
I came across this study recently:
Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells.
CONCLUSION:
Overall, our results suggest that EGCG ameliorates the negative effects of DHT by altering the miRNA expression profile in human DPCs.
DPC stands for dermal papilla cell, which is where the stem cell that the hair follicle grows from originates. It seems when looking not just at serum levels of the hormone, but actual RNA expression, that green tea seems to mitigate the effects of DHT.
Also seems to reduce rates of prostate cancer, which can be an issue for those on finasteride/dutasteride long term, though this is older research.
Dihydrotestosterone sensitises LNCaP (prostate cancer cell line) cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor.
This is in the setting of the probable negative effects that caffeine intake alone seems to have on the androgenic environment for hair loss:
Chronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostate.
Our results suggest that chronic caffeine intake from puberty increases androgenic signalling and cell proliferation in the rat prostate gland and can be related to the development of benign prostatic hyperplasia.
This study is very limited in that they fed the rats caffeine water, and though green tea and coffee obviously have caffeine, they are far more complex. And of course the prostate is not the dermal papilla, so take with a heavy dose of salt.
Bottom line: As the long term data on dutasteride is fairly limited (ie. as far as I know, we don't have data on whether if the effect reduces over time or if androgen receptors upregulate), it would be wise to inhibit 5a-reductase activity from more than one angle.
So, as per the most recent and well designed research, probably a good idea to drink both green and black tea. If you want be extra careful, just take EGCG in supplement form to avoid the caffeine. It's not going to give you the hairline of Ted Danson in your 50s, but might keep you closer to Jeff Bridges if you play your cards right.
In general, things that are good for your hairline tend to be good for your overall health, though with a few notable exceptions.
*Caveats: The former study is in vitro and the latter studies are in vivo but in animals. But we are holding up a very tiny candle light in the midst of a massive cave. Here be dragons, tread with caution. Or, as a wise poster here once said, 'I'll believe it when I can run my hand through it.' Still, drink for thought.
But that is old news.
Studies also pointed out that green tea increased testosterone, but no one knew how this related to its impact on DHT.
I came across this study recently:
Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells.
CONCLUSION:
Overall, our results suggest that EGCG ameliorates the negative effects of DHT by altering the miRNA expression profile in human DPCs.
DPC stands for dermal papilla cell, which is where the stem cell that the hair follicle grows from originates. It seems when looking not just at serum levels of the hormone, but actual RNA expression, that green tea seems to mitigate the effects of DHT.
Also seems to reduce rates of prostate cancer, which can be an issue for those on finasteride/dutasteride long term, though this is older research.
Dihydrotestosterone sensitises LNCaP (prostate cancer cell line) cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor.
This is in the setting of the probable negative effects that caffeine intake alone seems to have on the androgenic environment for hair loss:
Chronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostate.
Our results suggest that chronic caffeine intake from puberty increases androgenic signalling and cell proliferation in the rat prostate gland and can be related to the development of benign prostatic hyperplasia.
This study is very limited in that they fed the rats caffeine water, and though green tea and coffee obviously have caffeine, they are far more complex. And of course the prostate is not the dermal papilla, so take with a heavy dose of salt.
Bottom line: As the long term data on dutasteride is fairly limited (ie. as far as I know, we don't have data on whether if the effect reduces over time or if androgen receptors upregulate), it would be wise to inhibit 5a-reductase activity from more than one angle.
So, as per the most recent and well designed research, probably a good idea to drink both green and black tea. If you want be extra careful, just take EGCG in supplement form to avoid the caffeine. It's not going to give you the hairline of Ted Danson in your 50s, but might keep you closer to Jeff Bridges if you play your cards right.
In general, things that are good for your hairline tend to be good for your overall health, though with a few notable exceptions.
*Caveats: The former study is in vitro and the latter studies are in vivo but in animals. But we are holding up a very tiny candle light in the midst of a massive cave. Here be dragons, tread with caution. Or, as a wise poster here once said, 'I'll believe it when I can run my hand through it.' Still, drink for thought.
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