Taiwan develop novel HM method -07 Aug 08

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Scientists developed new platform for large-scale production of dermal papilla microtissues for hair follicle regeneration -

Scientists at the Institute of Biomedical Engineering, National Taiwan University developed new platform for large-scale production of dermal papilla microtissues for hair follicle regeneration. Dermal papilla is know to be essential for the induction of the regeneration of new hair follicles (so-called hair multiplication) in adult animals and humans.

Major obstacle in achieving effective large-scale hair regeneration platform based on use of dermal papilla induction properties is in inability to efficiently produce dermal papilla aggregates in cell culture.

Now scientists developed cell culture platform when dermal papilla cells are seeded onto poly(ethylene-co-vinyl alcohol) (EVAL) membranes. EVAL facilitates dermal papilla cells self-assembly into many compact spheroidal microtissues that are able to induce new hair follices. This system can be used as part of large-scale efficient hair multiplication protocol.

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New hair follicles induced by dermal papillae microtissues

This study is published in 2008 edition of journal Biomaterials
 
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Re: Taiwan develop novel HM method - 31 Jul 08

Title:
Self-assembly of dermal papilla cells into inductive spheroidal microtissues on poly(ethylene-co-vinyl alcohol) membranes for hair follicle regeneration. or not only

Author(s):
Young TH or not only, Lee CY or not only, Chiu HC or not only, Hsu CJ or not only, Lin SJ or not only


Abstract:

Self-aggregation is key to hair follicle (HF) induction ability of dermal papilla (DP) cells and neogenesis of HF can be achieved by transplanting DP microtissues. However, there is currently lack of a suitable system that allows efficient production of DP microtissues and analysis of DP self-aggregation in vitro. We demonstrate that, at a higher seeding cell density, poly(ethylene-co-vinyl alcohol) (EVAL) membranes facilitate DP self-assembly into many compact spheroidal microtissues that are able to induce new HFs. This self-assembling process is associated with an enhanced cell movement and a declined cell-substrate adhesivity on EVAL. A compromised cell growth is also revealed on EVAL. On the contrary, a more adherent surface allows faster cell expansion but maintains DP cells in a flat morphology. Dynamically, cell migration, intercellular collision and intercellular adhesion contribute to DP microtissue formation on EVAL. Our results suggest that, for large-scale production of DP microtissues for HF regeneration, an adhesive surface is needed for quick cell expansion and a biomaterial with a lower adhesivity is required for self-aggregation. In addition, this system can be a model for investigation of DP self-aggregation in vitro.


Source: Biomaterials (Biomaterials) or not only
Journal Rank: 8.20308799848442Rank is based on: Journal Citation Reports® Impact Factors published by Thomson Scientific, Inc. Rank range: from 0.01 to 100
Forward Citations: No PubMed citations
Volume: 29(26)
Publication Date: 07-08-2008
Research Institution: Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Sec. 1, Jen-Ai Road, Taipei 100, Taiwan.
Publication Type: Journal Article
Publication Language: eng
Main Field(s) of Science/Medicine: ,
Additional Field(s) of Science/Medicine:
 
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