systemic absorption of topical spironolactone

[waynakyo]

Any studies on the issue? I know most claim no systemic effect, but is that simply due to the weakness of spironolactone? (since RU, flutamide, and similar anti-androgens have clearly systemic effects).

 

[ladysmanfelpz]

It definitely has some. When I first started it I was loading it up, then one night I had 3 beers with some buddies and felt like I was wasted and near started spinning and had to go pass out. I woke up with a pretty bad hang over too. Now I apply much less, but sometimes can "feel it" say 30 mins to 2 hours after absorption in ways like metallic taste on the tongue and more frequent urination, but nothing else other than that.

 

[rcom440]

It gets absorbed locally and there were some serious studies about absorption of topical spironolactone.
But,
I believe if someone is super sensitive and applies a lot of spironolactone then he can develop side effects.
Just decrease amount you are using and see how it goes.