Summing up, is DHT the main reason of male pattern baldness?

[Fat-Elvis]

As for it being expensive, you can get a year's supply of real generic dutasteride (assuming you take one pill a day) for $360 from InHouse Pharmacy.

I was just going to add, this is if you take .5mg every single day. I myself am probably going to start off at maybe 2 or 3 pills a week, so at that price per pill it's about $150 a year (if I don't up the dosage).

 

[Guest]

As for it being expensive, you can get a year's supply of real generic dutasteride (assuming you take one pill a day) for $360 from InHouse Pharmacy.

I was just going to add, this is if you take .5mg every single day. I myself am probably going to start off at maybe 2 or 3 pills a week, so at that price per pill it's about $150 a year (if I don't up the dosage).

yeah i said assuming one pill a day.

 

[abcdefg]

Im skeptical of 5-ar 2 inhibitors. I asked morphollica.coms creator of revivogen and he said science doesnt know what DHT even really does. It crosses the bbb and has some effect on hairloss and acne, but no one has any clue what else DHT is doing in enough detail to say its safe to stop it.

 

[docj077]

Im skeptical of 5-ar 2 inhibitors. I asked morphollica.coms creator of revivogen and he said science doesnt know what DHT even really does. It crosses the bbb and has some effect on hairloss and acne, but no one has any clue what else DHT is doing in enough detail to say its safe to stop it.

There's nothing to be skeptical about with 5ARII inhibitors. 5AR type I is still producing DHT to somewhat maintain plasma levels. With an inhibitor that targets both like dutasteride., I really don't know what to think anymore. I would still use either, if I could.

 

[Bryan]

I think it would be very interesting if we had a THIRD 5a-reductase inhibitor (besides finasteride and dutasteride) available to us on the commercial market: one that had the awesome power that dutasteride has to inhibit the type 2 enzyme (close to 100% inhibition), but negligible activity against the type 1 enzyme (like finasteride). That could help establish just how much of dutasteride's modestly greater effectiveness for male pattern baldness is due to the nearly complete inhibition of type 2, and how much is due to the partial inhibition of type 1.

Of course, I suppose that the same thing could probably be accomplished by using elevated amounts of finasteride, like maybe taking a Proscar tablet 4 to 6 times a day, spread evenly throughout the day. But how many people (test subjects and doctors alike) would have the cajones to do such an experiment?? :wink:

Bryan

 

[chino20]

I'll do it if you buy me the proscar lol

 

[abcdefg]

Hmm. Interesting. So docj you would use either dutasteride or propecia if you could? Even knowing all you know about what DHT does and we all know it does an awful lot. Would it be riskier to take curcumin instead of propecia?

I think my main problem is im still scared it might not be male pattern baldness and i dont want to make the problem worse.

 

[docj077]

there bad man doctors have told me how bad they are..do you know more then a doctor jayman..DR WOODS from thewoodstechnique.com told me when i seen him for a consiltation that prolonged use of systemic dht inhibitors will in alot of cases cause oesteopherosis

He needs to explain that to you, because what he's saying makes absolutely no sense. Both DHT and testosterone increase collagen synthesis, but only testosterone is converted into estrogen, which acts at the level of the osteoblast to increase proliferation, and thus, bone deposition.

 

[abcdefg]

I wonder if the merk guys that made finasteride take it themselves? that would speak a lot if they are still using it to this day.

 

[Old Baldy]

The link below (go to roughly 1/4 of the way down in the text) is what I find most of the time relative to male hormones and bone loss.

It is the decline in circulating free testosterone and overall testosterone that most of the pros feel causes male bone loss as we get older.

http://www.eje-online.org/cgi/content/full/154/2/175

Here's an excerpt:

Age-related osteoporosis is now considered to be a consequence of the progressive impairment of the hypothalamic–pituitary–gonadal axis in men (14) and, even though a corresponding dramatic fall of sex hormones as happens in menopause does not occur in men, the continuous slow reduction in circulating androgens, as well as changes in total and bioavailable serum testosterone in men, are strongly related to bone loss (2, 8).

So yes, maybe lowering DHT has some effect but it doesn't appear that the pros feel it has a significant effect because we don't have much circulating DHT?

Maybe take DHEA? Maybe get your testosterone levels checked by a doctor and get on testosterone replacement treatment if needed?

If it wasn't for the a**hole pro weightlifters and atheletes, we could still get testosterone to use moderately and get us back to healthy levels without having to go to a doctor. But, as usual, the abusers screwed it up for the rest of us.

 

[flimflam]

one that had the awesome power that dutasteride has to inhibit the type 2 enzyme (close to 100% inhibition), but negligible activity against the type 1 enzyme (like finasteride).
Bryan

Bryan,
what about combining finasteride with a topical anti-androgen such as fluridil? that would be pretty close to dutasteride type 2 inhibition standards right?

 

[Nick4441]

i'm not convinced DHT is the only cause of hairloss. I took saw palmetto then finasteride over last year and my hairloss has got prgressively worse..my hairline continues receding and diffuse thinning like a bast**d. I see no samll regrowth hairs at all over this period just continual loss of hair.
My testosterone is the highest its ever been if its related to sex drive, it was always high but not this high so I think finasteride has helped that and that's increased the hairloss.

I got to make a decision whether to stop or not after all this effort and expense. i don't know whether its worth trying avodart or would I just become a sex maniac and bald as a coote.

 

[Stu85]

i'm not convinced DHT is the only cause of hairloss. I took saw palmetto then finasteride over last year and my hairloss has got prgressively worse..my hairline continues receding and diffuse thinning like a bast**d. I see no samll regrowth hairs at all over this period just continual loss of hair.
My testosterone is the highest its ever been if its related to sex drive, it was always high but not this high so I think finasteride has helped that and that's increased the hairloss.

I got to make a decision whether to stop or not after all this effort and expense. i don't know whether its worth trying avodart or would I just become a sex maniac and bald as a coote.

Well, Nick you haven't been on finasteride for that long. According to your regimen it's been over 4 months, right? As for the other things, well we don't know if Saw Palmetto and Pr0cerin actually help.

 

[Stu85]

I wonder if the merk guys that made finasteride take it themselves? that would speak a lot if they are still using it to this day.

That would be interesting. I do know Dr. Rassman from baldingblog.com takes Propecia. That's somewhat different, I know, but he is a doctor and has devoted his life to hairloss, so that must count for something...

 

[Old Baldy]

I wonder if the merk guys that made finasteride take it themselves? that would speak a lot if they are still using it to this day.

That would be interesting. I do know Dr. Rassman from baldingblog.com takes Propecia. That's somewhat different, I know, but he is a doctor and has devoted his life to hairloss, so that must count for something...

I think it counts alot.

Hasson and Wong recommend dutasteride to their hair transplant patients regularly.

I might get flamed for this but, IMHO, our reaction to DHT is a MAJOR factor in baldness. IMHO it starts the "downward spiral".

If only, as Bryan has said, we could discover why beard follicles respond favorably to DHT while scalp follicles respond badly! :-x