Success With Dutasteride When Failed With Finasteride

Michael Bonawitz

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Greetings all!

I'm a long time lurker on this forum. I have been dealing with Androgenetic Alopecia since I was 21 years old.
I started taking generic finasteride and using Rogaine in August of 2017, and for the first year, I held on to the hair I already had and grew a little bit around my temples.
Around November of that same year, my progress fell way beyond baseline and sent me into a panic.
I currently live in Japan, and went to a Androgenetic Alopecia specialist. After explaining my situation, they perscribed me Zagallo (name brand dutasteride for Androgenetic Alopecia in Japan).
I stopped finasteride immediately and starting taking dutasteride in December of 2018. I also bumped my topical minoxidil to 15 %.

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The above pictures were the condition of my hairline in March of this year. Fast forward to September...

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So after taking Dutasteride for 9 months and upping the minoxidil, I finally feel like I'm making progress.

My current regimen is:

I take 0.5mg of dutasteride EOD
2.5mg of Oral minoxidil ED
15% or Topical Minoxidil twice a day

I'm also 26 years old, haven't experienced any physical side effects. Mental on the other hand, I find it more difficult to deal with stress at times, but besides that everything is fine.

Please feel free to ask any questions!
 
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DuckThisSheet

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First of all, that regrow is f*****g nice, congratz

In your regimen there is also oral minoxidil - Do you take it, what is the dose>?
What dose of Duta are you taking? Do you take it everyday?
Did you shed when you switched to duta>?
Did you consider taking both finasteride and Duta?
Would you advice ppl to switch from Fina to Duta to see better results? :D
 

Michael Bonawitz

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Thanks mate!

I forgot to mention, so I'll eddit my main post.

Along with the dutasteride, my dermatologist in Japan perscribed oral minoxidil as well (another common treatment for Androgenetic Alopecia here).

I take 0.5mg of dutasteride EOD
2.5mg of Oral minoxidil ED
15% or Topical Minoxidil twice a day

When I switched from finasteride to dutasteride, I did have a pretty massisve shed about 3 months into the treatment, which last for what felt like 2 months. I began to doubt if this regime was going to help me or not. But I just stuck it out and surely enough I stared to get decent regrowth about 2 months ago.

I would recommend dutasteride to anybody who has been taking finasteride for at least a year, doesn't have adverse side effects, and have not gained desirable results.
 

DuckThisSheet

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Do you have any photos of hairline in December of 2018? Would give me more info than photos in March when you have been shedding :x

I really consider switching from Fina to Duta, but im still not sure
 

Michael Bonawitz

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All my photos from when I started Fina are gone since that phone broke. My hairline did not get worse when I switched to Duta, I just had shedding all over my scalp.
 

Harv

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I also recently made the switch, however i was on finasteride for 8months in combination with duta for 6months.
The regime was working well as i wasnt shedding or felt scalp inflammation/tingling.
Ive dropped fina for 3 days now and my scalp is tingling again and hairs falling out, assume the dht has crept back in my scalp.
Im just bemused how this is happening as im still on advodart and been on it for 6months.
Could it be that when taking both together ia more potent?
 

Michael1986

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I also recently made the switch, however i was on finasteride for 8months in combination with duta for 6months.
The regime was working well as i wasnt shedding or felt scalp inflammation/tingling.
Ive dropped fina for 3 days now and my scalp is tingling again and hairs falling out, assume the dht has crept back in my scalp.
Im just bemused how this is happening as im still on advodart and been on it for 6months.
Could it be that when taking both together ia more potent?
I think this must be a placebo effect. Taking both finasteride and dutasteride together will not be any more potent than taking dutasteride alone. Furthermore, it would take longer than just three days for DHT levels to reduce significantly as a result of stopping finasteride usage (which would not happen anyway if you are continuously using dutasteride during and after stopping finasteride, as in your case).
 

Harv

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I think this must be a placebo effect. Taking both finasteride and dutasteride together will not be any more potent than taking dutasteride alone. Furthermore, it would take longer than just three days for DHT levels to reduce significantly as a result of stopping finasteride usage (which would not happen anyway if you are continuously using dutasteride during and after stopping finasteride, as in your case).

logically i agree with what your saying and thats why i dropped fina, HOWEVER, 100% my scalp became more oily and tingling returned and alot of hair easily comming out, its not a placebo effect.
One theory someone told me is that my body was used to being on fina for 8months and quiting cold turkey was going to cause some sort of reaction to my system.
Its so strange as it seems like finasteride was suppressing the dht better. Fina shot up my testerone as it was converting the dht to Testerone and consequently my i had an increased libido.
As soon as i dropped finasteride my libido went down and producing less sperm.
I understand that finasteride takes a couple weeks to get out of the system so should i expect the dht to gradually or perhaps duta is waiting for fina to get out the system so it can overtake as bizzare as that sounds
 

Michael1986

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logically i agree with what your saying and thats why i dropped fina, HOWEVER, 100% my scalp became more oily and tingling returned and alot of hair easily comming out, its not a placebo effect.
One theory someone told me is that my body was used to being on fina for 8months and quiting cold turkey was going to cause some sort of reaction to my system.
Its so strange as it seems like finasteride was suppressing the dht better. Fina shot up my testerone as it was converting the dht to Testerone and consequently my i had an increased libido.
As soon as i dropped finasteride my libido went down and producing less sperm.
I understand that finasteride takes a couple weeks to get out of the system so should i expect the dht to gradually or perhaps duta is waiting for fina to get out the system so it can overtake as bizzare as that sounds
The way that 5ar inhibitors work chemically is that if you are using the two together, the effect of the stronger one will override the effect of the weaker one. They do not work synergistically with one another. Dutasteride removes more DHT than finasteride does for at least 99% of people (and probably more like 99.99% of people), the exception being a tiny number of people who carry (and would most likely need to be homozygous for) a very rare mutant variant of the 5ar type 2 allele that happens to display a higher affinity to finasteride than to dutasteride. This was demonstrated in a study I read recently. Unless you are one of these very rare people, dutasteride (at the usual dosing scheme of 0.5mg a day) will inhibit more of your DHT than finasteride will, and taking both drugs together will not result in any more DHT inhibition than just taking dutasteride on its own would. Therefore, I don't see a way whereby there could be a change in your DHT levels after stopping finasteride, as you are continuing to use dutasteride. Consequently, I don't see how there would be any withdrawal effects, as it is the change in DHT levels that causes any such withdrawal effects in the first place. So to conclude, if the symptoms you are experiencing are not a placebo effect, it would seem to me that there must be some other unrelated cause for these symptoms.
 
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Harv

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The way that 5ar inhibitors work chemically is that if you are using the two together, the effect of the stronger one will override the effect of the weaker one. They do not work synergistically with one another. Dutasteride removes more DHT than finasteride does for at least 99% of people (and probably more like 99.99% of people), the exception being a tiny number of people who carry (and would most likely need to be homozygous for) a very rare mutant variant of the 5ar type 2 allele that happens to display a higher affinity to finasteride than to dutasteride. This was demonstrated in a study I read recently. Unless you are one of these very rare people, dutasteride (at the usual dosing scheme of 0.5mg a day) will inhibit more of your DHT than finasteride will, and taking both drugs together will not result in any more DHT inhibition than just taking dutasteride on its own would. Therefore, I don't see a way whereby there could be a change in your DHT levels after stopping finasteride, as you are continuing to use dutasteride. Consequently, I don't see how there would be any withdrawal effects, as it is the change in DHT levels that causes any such withdrawal effects in the first place. So to conclude, if the symptoms you are experiencing are not a placebo effect, it would seem to me that there must be some other unrelated cause for these symptoms.

appreciate the response, the above of what you said I do understand and knew about it but its definately dropping the fina caused it, its no concidece that the first few days without fina all these symptoms came back. I dont have an underlying issue as I had my blood test done, only worrying thing was i have a low white blood cell count which apparently i have most likely a viral infection which i have no idea what could be as im not ill.
i really just think generic fina hit my system much harder in blocking dht, im just going by how my body reacts because othweriwse i have no logical explanation.
 
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