Study Offers New Insights Into Causes Of Premature Baldness In Men

[c_super2]

New male pattern baldness info.

Source: http://www.news-medical.net/news/20...ical-causes-of-premature-baldness-in-men.aspx

 

[SmoothSailing]

Short men may have an increased risk of becoming bald prematurely.

Manlets can't catch a break.

 

[InBeforeTheCure]

Link to paper: http://www.nature.com/articles/ncomms14694

Abstract:

Male-pattern baldness (male pattern baldness) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of male pattern baldness to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 male pattern baldness-associated loci (P<5 × 10−8, METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in male pattern baldness and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of male pattern baldness and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, male pattern baldness shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.

 

[Armando Jose]

women were not included in the study?

wrong item.

 

[N003]

Stupid study....i have many "short" friends with full hairs.

 

[Afro_Vacancy]

Stupid study....i have many "short" friends with full hairs.

That's not how science works.

Baldness is a multivariable, probabilistic phenomenon. There will be exceptions to virtually every trend.

 

[pjhair]

That's not how science works.

Baldness is a multivariable, probabilistic phenomenon. There will be exceptions to virtually every trend.

This. When will people realize that their friends/acquaintances are too small a sample to make conjectures about entire population. I have seen people repeat this fallacy over and over again on various issues.

 

[Dante92]

That's not how science works.

Baldness is a multivariable, probabilistic phenomenon. There will be exceptions to virtually every trend.

 

[abcdefg]

Another way of saying incurable, and no one knows anything about it. What we concretely know about male pattern baldness is maybe a small vague diagram before you go off into unexplored unknown territory. Hardly anything with male pattern baldness has real answers. At least yet, but it progresses so slowly I think we might be dead before most of it is understood.

"Baldness is a multivariable, probabilistic phenomenon."

 

[alebaba]

What a bs article, not even a real study.

 

[pegasus2]

Because when your genes suck, there's no end to your misery. Shitty genes usually come in a whole package.

Height is actually more associated with childhood nutrition than with genetics. Thyroid problems and dwarfism aside, most people of the same race would be within a couple inches given the same nutrition.

 

[pegasus2]

Another way of saying incurable, and no one knows anything about it. What we concretely know about male pattern baldness is maybe a small vague diagram before you go off into unexplored unknown territory. Hardly anything with male pattern baldness has real answers. At least yet, but it progresses so slowly I think we might be dead before most of it is understood.

"Baldness is a multivariable, probabilistic phenomenon."

That's the beauty of it, we don't have to understand it to have a functional cure, i.e. hair multiplication.

 

[Afro_Vacancy]

So we become bald to catch more sunlight?
I've read about that theory a few years ago...

I doubt it.

Cavemen didn't even wear shirts?

 

[Grasshüpfer]

I doubt it.

Cavemen didn't even wear shirts?

Cavemen in Europe were dressed thickly of course. It's not t shirt weather here except a few months in summer.

 

[InBeforeTheCure]

So we become bald to catch more sunlight?
I've read about that theory a few years ago...

This doesn't really imply an evolutionary purpose for baldness. One of the genes associated with baldness, IRF4, regulates expression of tyrosinase in melanocytes -- tyrosinase is the enzyme that converts tyrosine to melanin. Another is C10orf11, which is involved in melanocyte differentiation. Mutations in C10orf11 cause albinism. Selection for light skin was very strong in prehistoric Europe, so a higher rate of baldness could be a "side effect" of the evolution of light skin. Apparently melanocytes can affect whether you go bald or not. Maybe this is due to melanin, or maybe it's something else in melanocytes, who knows?

 

[dralex]

Weird...I am much lighter skin than my brothers and the only one out of us balding. Coincidence....? Yes, probably.

 

[whoken]

Yes coincidence, just visit North Africa, or most other mediteranean regions where people are darker than the usual european. Yet the rate of balding there is similar or higher than it is here in Europe.

 

[Feelsbadman.jpg]

Short, bald, heart disease, and prostate cancer. Sounds about right..... How do these god awful genes get passed on? WTF happened to natural selection and survival of the fittest.......

At least this "study" helps to show that baldness is not just a cosmetic disorder, it's a giant genetic flag that screams, "I'm prone to disease and cancer and am genetically inferior".

 

[plisk]

Short, bald, heart disease, and prostate cancer. Sounds about right..... How do these god awful genes get passed on? WTF happened to natural selection and survival of the fittest.......

At least this "study" helps to show that baldness is not just a cosmetic disorder, it's a giant genetic flag that screams, "I'm prone to disease and cancer and am genetically inferior".

Thats because your understanding of "natural selection" and "survival of the fittest" is completely wrong and based off cartoonish notions.

The only event where the world wouldve ever had a race of singularly healthy, tall, beautiful people with no genetic disease wouldve been if the Nazis had been allowed their eugenics programs to go into full swing or if the fascination with eugenics in the west survived the post war hatred of anything associated with Nazi germany.

But A) it didn't and B) even if it did it is likely someone in power wouldve fucked such an ambitious program up with their own biases anyway.

 

[Afro_Vacancy]

Thats because your understanding of "natural selection" and "survival of the fittest" is completely wrong and based off cartoonish notions.

The only event where the world wouldve ever had a race of singularly healthy, tall, beautiful people with no genetic disease wouldve been if the Nazis had been allowed their eugenics programs to go into full swing or if the fascination with eugenics in the west survived the post war hatred of anything associated with Nazi germany.

But A) it didn't and B) even if it did it is likely someone in power wouldve fucked such an ambitious program up with their own biases anyway.

The Man in the High Castle.

Good television.