Study Of Gene Expression Alteration In Male Androgenetic Alopecia | HairLossTalk Forums

Study Of Gene Expression Alteration In Male Androgenetic Alopecia

Discussion in 'Hair Loss and Alopecia Published Studies' started by baldco, Jun 7, 2017.

  1. baldco

    baldco New Member My Regimen

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    https://www.ncbi.nlm.nih.gov/pubmed/28403520
    Abstract

    BACKGROUND:
    Male androgenetic alopecia (Androgenetic Alopecia) is the most common form of hair loss in men and is characterized by a distinct pattern of progressive hair loss starting from the frontal area and the vertex of the scalp. Although several genetic risk loci have been identified, relevant genes for Androgenetic Alopecia remain to be defined.

    OBJECTIVES:
    Herein, molecular biomarkers associated with premature Androgenetic Alopecia were identified through gene expression analysis using cDNA generated from scalp vertex biopsies of hairless/bald men with premature Androgenetic Alopecia and healthy volunteers.

    RESULTS:
    This monocentric study reveals that genes encoding mast cell granule enzymes, inflammatory and immunoglobulin-associated immune mediators were significantly over-expressed in Androgenetic Alopecia. In contrast, under-expressed genes appear to be associated with the Wnt/β-catenin and BMP/TGF-β signaling pathways. Although involvement of these pathways in hair follicle regeneration is well-described, functional interpretation of the transcriptomic data highlights different events that account for their inhibition. In particular, one of these events depends on the dysregulated expression of proopiomelanocortin (POMC), as confirmed by RT-qPCR and immunohistochemistry. In addition, lower expression of CYP27B1 in Androgenetic Alopecia subjects supports the notion that changes in vitamin D metabolism contributes to hair loss.

    CONCLUSION:
    This study provides compelling evidence for distinct molecular events contributing to alopecia that may pave way for new therapeutic approaches. This article is protected by copyright. All rights reserved.
     
    Afro_Vacancy and resu like this.
  2. resu

    resu Senior Member

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    There you go, it's finally confirmed.
     
  3. rclark

    rclark Senior Member My Regimen

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    So they think vitamin D is related to hair loss? They don't know what genes are involved.
     
  4. c_super2

    c_super2 Established Member

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    How do we fix the vitamin D problem?
     
  5. IvanXproject

    IvanXproject Established Member

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    Could you please also post this in the New Research, Studies and Technologies section? I think more people need to see this!
     
  6. lamch

    lamch Member

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    Ive just been reading some posts of people using vitamin D3 topically, and alot of them seem to be having success... Interesting. Maybe worth a try?
     
  7. IvanXproject

    IvanXproject Established Member

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    @InBeforeTheCure
     
  8. InBeforeTheCure

    InBeforeTheCure Established Member My Regimen

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    Well, start here: How is VDR expression regulated in hair follicles?
     
  9. arnoldd

    arnoldd Experienced Member

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    Hey guys

    "This monocentric study reveals that genes encoding mast cell granule enzymes, inflammatory and immunoglobulin-associated immune mediators were significantly over-expressed in Androgenetic Alopecia. "
    Does this mean that any immune response like a infection or virus could affect hair loss and speed up mbp since we have an upregulation of the immune mediators in our scalp?

    Or the overexpression of the immune cells in the bald scalp are just a consequence from the attack of dht ?
     
  10. Trichosan

    Trichosan Senior Member My Regimen

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    https://ghr.nlm.nih.gov/gene/CYP27B1

    Assuming the vit D3 correlation is valid, people should get their 25, hydroxy levels checked BEFORE they start losing their hair. Supplement to make sure levels are OPTIMAL not just in range.
     
  11. zigzag

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    Remember, always take D3 WITH K2
     
  12. Trichosan

    Trichosan Senior Member My Regimen

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    Why, Grasshopper?
     

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