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Patients wich Large Prostate Size show higher prevalence of Androgenetic Alopecia
Chao-Chun Yang, Tzong-Shin Tzai, Meng-Chi Wu, WenHieh Chen Department of Dermatology and Urology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Department of Dermatology Chang Gung University, Kaohsiung Chang Gung Memorial Hospital Kohsiung, Taiwan
Objectives:
Androgenetic Alopecia (Androgenetic Alopecia) or Male Pattern Baldness and Benign Prostatic Hyperplasia (BPH) are both androgen-dependent disorders. Both display high levels of dihydrotestosterone with good therapeutic response to finasteride, a specific type II 5ar inhibitor. The hair follicle and prostate share similarities in embryological development related to 5a-reductase. The present study aims to understand the association between the prostate size and the prevalence and severity of Androgenetic Alopecia.
Methods:
97 patients (average age 70 years old) were retrospectively recruited from the Urology clinic. BPH was defined and diagnosed by (1) Prostate size of greater than 20cm cubed measured via an ultrasound (2) Maximum urine flow rate of less than 15ml per second and average flow rate of less than 10ml per second ... and lastly (3) A PSA level of less than 10ng/ml. Included as controls for this study were patients with conditions such as prostatitis, infections, or other non BPH related prostate inflammations.
(This effectively separated them from the BPH group which had larger prostates due to androgen related causes.)
* The presence and severity of Androgenetic Alopecia were evaluated by dermatologists using a modified Norwood/Hamilton classification.
* The difference of prevalence was analyzed by "Chi-square test".
* The correlation between severity of Androgenetic Alopecia and size of prostate was estimated by "Spearman's rank correlation test".
* Comparison of average prostate size in Androgenetic Alopecia versus non-Androgenetic Alopecia patients was analyzed by "Student's T-Test".
Results:
Patients with prostate size larger than 30cm cubed in volume have higher prevalence of Male Pattern Baldness (Androgenetic Alopecia) than patients with smaller prostate sizes. The prostate size, however, does not correlate with the severity of hair loss in either group. The *prevalence* of male pattern baldness is not significantly different in patients with or without BPH. The average prostate size is slightly larger in patients with male pattern baldness than those without male pattern baldness, but this is not statistically significant. There is no significant correlation between the onset age of male pattern baldness and the development of BPH.
Conclusions:
Patients with larger prostate size seem to have higher prevalence of Male Pattern Baldness. It remains to be seen if long-term use of Finasteride (Propecia) in people with male pattern baldness could prophylactically lower the incidence of BPH.
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Chao-Chun Yang, Tzong-Shin Tzai, Meng-Chi Wu, WenHieh Chen Department of Dermatology and Urology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Department of Dermatology Chang Gung University, Kaohsiung Chang Gung Memorial Hospital Kohsiung, Taiwan
Objectives:
Androgenetic Alopecia (Androgenetic Alopecia) or Male Pattern Baldness and Benign Prostatic Hyperplasia (BPH) are both androgen-dependent disorders. Both display high levels of dihydrotestosterone with good therapeutic response to finasteride, a specific type II 5ar inhibitor. The hair follicle and prostate share similarities in embryological development related to 5a-reductase. The present study aims to understand the association between the prostate size and the prevalence and severity of Androgenetic Alopecia.
Methods:
97 patients (average age 70 years old) were retrospectively recruited from the Urology clinic. BPH was defined and diagnosed by (1) Prostate size of greater than 20cm cubed measured via an ultrasound (2) Maximum urine flow rate of less than 15ml per second and average flow rate of less than 10ml per second ... and lastly (3) A PSA level of less than 10ng/ml. Included as controls for this study were patients with conditions such as prostatitis, infections, or other non BPH related prostate inflammations.
(This effectively separated them from the BPH group which had larger prostates due to androgen related causes.)
* The presence and severity of Androgenetic Alopecia were evaluated by dermatologists using a modified Norwood/Hamilton classification.
* The difference of prevalence was analyzed by "Chi-square test".
* The correlation between severity of Androgenetic Alopecia and size of prostate was estimated by "Spearman's rank correlation test".
* Comparison of average prostate size in Androgenetic Alopecia versus non-Androgenetic Alopecia patients was analyzed by "Student's T-Test".
Results:
Patients with prostate size larger than 30cm cubed in volume have higher prevalence of Male Pattern Baldness (Androgenetic Alopecia) than patients with smaller prostate sizes. The prostate size, however, does not correlate with the severity of hair loss in either group. The *prevalence* of male pattern baldness is not significantly different in patients with or without BPH. The average prostate size is slightly larger in patients with male pattern baldness than those without male pattern baldness, but this is not statistically significant. There is no significant correlation between the onset age of male pattern baldness and the development of BPH.
Conclusions:
Patients with larger prostate size seem to have higher prevalence of Male Pattern Baldness. It remains to be seen if long-term use of Finasteride (Propecia) in people with male pattern baldness could prophylactically lower the incidence of BPH.
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