Strange ideas when you're up all night

[Stingray]

As the name suggests, I was up all night last night thinking. I don't know why, I think it's just my insanity peaking through. I was thinking about how the body works, and why the body attacks hair follicles that are being weakened by DHT and it hit me. Why hasn't anyone tried a topical pure anti-inflammatory procedure using potent medicines? Now, I'm fairly sure that I'm not a pioneer in this field, but I haven't read anything about it except for the random cortizone injection here and there. So I figured, if cortizone can relieve inflammation on the scalp, and sometimes cause hair to regrow (I think people have claimed this), what about a non steroidal anti-inflammatory? I have already started an experiment on this today...cuz i was bored primarily. I dissolved 1500mg naproxen (an NSAID, main ingredient in Aleve if I recall) in 60mL of 70% Isopropyl alcohol (not all of it will dissolve, but I'm letting it sit to see if the chunks still need to dissolve too). I don't know the percentage of the drug by volume in the mixture, but if the pills were pure naproxen, then the solution comes out to be 6.25% by volume.

My question... is inflammation a key player in hairloss? If so, then a local high potency anti-inflammatory would be a good addition to any remedy. If I decide to be REAL hardcore, I might just try my concoction on myself to see what happens.

Just thought that would be something interesting.

 

[Guest]

As the name suggests, I was up all night last night thinking. I don't know why, I think it's just my insanity peaking through. I was thinking about how the body works, and why the body attacks hair follicles that are being weakened by DHT and it hit me. Why hasn't anyone tried a topical pure anti-inflammatory procedure using potent medicines? Now, I'm fairly sure that I'm not a pioneer in this field, but I haven't read anything about it except for the random cortizone injection here and there. So I figured, if cortizone can relieve inflammation on the scalp, and sometimes cause hair to regrow (I think people have claimed this), what about a non steroidal anti-inflammatory? I have already started an experiment on this today...cuz i was bored primarily. I dissolved 1500mg naproxen (an NSAID, main ingredient in Aleve if I recall) in 60mL of 70% Isopropyl alcohol (not all of it will dissolve, but I'm letting it sit to see if the chunks still need to dissolve too). I don't know the percentage of the drug by volume in the mixture, but if the pills were pure naproxen, then the solution comes out to be 6.25% by volume.

My question... is inflammation a key player in hairloss? If so, then a local high potency anti-inflammatory would be a good addition to any remedy. If I decide to be REAL hardcore, I might just try my concoction on myself to see what happens.

Just thought that would be something interesting.

Actually Dr Lee used to add coritzone to his topicals but got taken to task for the negative impact on the skin as a result of long term used. He has since dropped it as an ingredient I believe.

Good luck on the experiment.

 

[Stingray]

Well, cortizone is a steroid, and steroidal compounds usually have negative long term impacts on the body. I'll see what happens. Could be interesting.

 

[ShedMaster]

Well, cortizone is a steroid, and steroidal compounds usually have negative long term impacts on the body. I'll see what happens. Could be interesting.

Feel free to be our gineau pig and let us know what happens!

:salut:

 

[maddoc23]

You could always take a baby aspirin a day.

D

 

[Redbone]

Dr Lee still adds BV which is cortisone to his formulas but it can be had without it as well. It is a .0025 concentration which is supposedly insignificant.

 

[Guest]

From the Skin Biology website!!




Xandrox is a product from Dr. Robert Lee (picture to the left) who sells various mixtures of products for hair growth at http://www.minoxidil.com. Xandrox is consists of 5% to 12% Minoxidil and Azelaic Acid. Avoid the version of the product with Betamethasone Valerate. The latter is a corticosteroid included to counteract the effect of the Azelaic Acid which often causes skin irritation. Azelaic Acid, which is similar to retinoic acid, is normally used to treat acne and does have hair promoting properties in combination with minoxidil. Success rates on hair growth up to 70% are claimed. The versions without corticosteroids are basically OK.

The problem with the corticosteroid version is what happens with long term use? The long term use of corticosteroids on skin inflammations is usually disastrous with severe skin thinning and chronic skin damage because the corticosteroids inhibit the natural skin repair processes.

Some Xandrox users have said that the amount of corticosteroid is too low to matter. But this is not true. Corticosteroids exert their typical actions at 10exp(-11) molar concentration. For a corticosteroid of 300 molecular weight, this amounts to a concentration of 3 X 10exp(-9) grams per liter or about 210 nanograms for the entire body. If you put 1 milliliter of a solution containing only 0.1% corticosteroid, the corticosteroid you are putting on your scalp is 1 milligram, or 1,000 micrograms or 1 million nanograms. Since corticosteroids easily cross the skin barrier and enter the body and you are putting 1 million nanograms of your scalp daily, and only 210 nanograms are needed to activate corticosteroid effects, it is inevitable that after long term use of the Xandrox, you will have put sufficient corticosteroids into your body to cause serious damage.

Furthermore, long term corticosteroid use can promote diabetic conditions, thymus involution (accelerates aging), immune suppression, muscle wasting, the spread of cancers, bone damage, and cataracts. It is estimated that 5,000 hip replacements yearly in Canada are due to overuse of corticosteroids.





So what happens if you grow beautiful hair with corticosteroids? As you crawl into bed to show off your gorgeous physical attributes to your loved-one or intended-to-be loved-one, you may have trouble seeing through the developing cataracts on your eyes and the insulin injections to control the corticosteroid-induced diabetes will have left needle tracks over your arms. The muscle wasting and fragile bones will slow your movements and anything more physical could put you at risk for broken bones. Bed partners are only impressed by hair in combination with a beautiful, healthy body.

If you want to use these types of azeliac/ retinoic acid/minoxidil combinations, copper-peptidres may help to control the scalp irritation.

 

[Stingray]

That's the exact reason I was saying that NSAIDs would be by far better than corticosteroids. I'm prolly not gonna try it... cuz I was really just wanting to try to crush something up with a spoon and mix it in to something else to see what would happen. But it's still a good idea. I might go the way of taking a baby aspirin a day. I was thinking that also. Plus there's only good things that are involved with that.

 

[Guest]

That's the exact reason I was saying that NSAIDs would be by far better than corticosteroids. I'm prolly not gonna try it... cuz I was really just wanting to try to crush something up with a spoon and mix it in to something else to see what would happen. But it's still a good idea. I might go the way of taking a baby aspirin a day. I was thinking that also. Plus there's only good things that are involved with that.

I take a baby asprin each day but there is primarily for CV health.

 

[fred]

since male pattern baldness itself is incurable. To fight hairloss you have to focus on the effects around male pattern baldness, like DHT activity, scalp environement etc... (That's no news to anyone) inflammation is one of these "effects". I have no clue what percentage inflammations play on hairloss, 10%?? 30%??? can an expert answer that question?? but like I said in a earlier post no-one paid attention: I've been to the dentist 2 weeks ago for a toothache and since I always had big inflammation problems, he prescribed me a powerful oral anti-inflammatory (Tilcotil) which nearly completly cured the itches of my scalp, but not my toothache :roll: . As an aggressive thinner, I don't know what part of my hairloss as been improved by dealing with the "inflamatory" side of the problem, 10% ? 30% ? probably 0%... it's too early to say, I seem to lose as much hair as before, but it will probably help in a long term I don't know, I don't want to scratch my head anymore and that's good at least for that alone.

My question... is inflammation a key player in hairloss? If so, then a local high potency anti-inflammatory would be a good addition to any remedy. If I decide to be REAL hardcore, I might just try my concoction on myself to see what happens.

 

[bombscience]

interesting thought sting, let me know how it goes.