spironolactone: what a wonderfull smell!!! delicious

[thylax]

this thing smell awful! Even if after you wash your hair...


f***ing hair loss, what a trouble!

 

[Sir_LagaLot]

are you still using spironolactone in minoxidil after being told the reaction between the two renders the mixture useless?

 

[Sir_LagaLot]

Preparation and clinical assessment of spironolactone-containing cream on hair growth in hirsute women

Saadat N, Salehi P, Emami A, Mortazavi A.

Endocrine Research Center; and Faculty of Pharmacy,
Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

Abstract:
Spironolactone is a diuretic antihypertensive drug which has been shown to produce antiandrogenic effects. The antiandrogenic effects of topical spironolactone have been proved in animals. In this study, we tried to prepare an effective formulation of topical spironolactone and also we evaluated its clinical effects in human. The study was performed in two phases: different formulations of topical spironolactone were examined in the first phase. Spironolactone creams containing 2% drug were prepared in aqueous cream, buffered, vanishing, oily, and cold cream bases and then physico-chemical tests including assessment of visual characteristics (appearance), uniformity, apparent viscosity and spread ability, drug release from the base, and assay of active ingredient were performed on each cream. In the second phase, the best formulation was applied twice daily for 3 months in 12 patients aged 17-50 years who suffered from mild to moderate hirsutism localized to the face. The patients used about 1 gram of the selected cream on one side of their face and did not remove or manipulate hair from that area throughout the study. The 2% spironolactone cream containing aqueous cream base was the best cream with the greatest stability and desirable physico-chemical properties. The clinical trial results from monthly assessments up to 3 months showed a lack of effectiveness of this formulation on hair growth compared with the other side of the face. Hirsutism and hair growth were not influenced by the application of the spironolactone-containing cream during 3 month of treatment. Other formulations or drug doses should be sought in the future studies.

 

[thylax]

Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

Is it reliable?

 

[thylax]

Are you saying to me that the mixture does nothing to my hair as minoxidil OR spironolactone?

 

[Sir_LagaLot]

yes to both your questions.

 

[Guest]

Dr Lee's spironolactone does not smell but it's expensive

 

[Sir_LagaLot]

make your own?..spironolactone is spironolactone..as long as its the active ingrediant..all you need to do is make sure it dissolves fine..

i get aldactone tabs..10 for a dollar..

 

[thylax]

orally?

 

[Sir_LagaLot]

orally?

yes...orally...and i'd recommend hair removal and a pink dress to go with
the breasts then..


nOt OrallY!...spironolactone is the most potent of all DHT inhibitors...i meant topically!..from aldactone tabs!..according to 'iamnaked' , they dissolve in rosewater+glycerine just fine..so apply it topically!..

unless you'd rather grow breasts than go bald..

 

[viperfish]

orally?

yes...orally...and i'd recommend hair removal and a pink dress to go with
the breasts then..


nOt OrallY!...spironolactone is the most potent of all DHT inhibitors...i meant topically!..from aldactone tabs!..according to 'iamnaked' , they dissolve in rosewater+glycerine just fine..so apply it topically!..

unless you'd rather grow breasts than go bald..

spironolactone is an anti-androgen and not a dht inhibitor.

 

[Dave001]

Preparation and clinical assessment of spironolactone-containing cream on hair growth in hirsute women

Saadat N, Salehi P, Emami A, Mortazavi A.

Endocrine Research Center; and Faculty of Pharmacy,
Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

[abstract snipped]

Old Baldy,

Can you provide the full citation or a link to that paper?

Thanks.

 

[Old Baldy]

Haven't been able to find the whole study, however, I did find a medical site that stated cream spironolactone. has not been shown to be effective for hirsutism when applied topically. Seems to be an acknowledged fact among professionals.

http://216.109.125.130/search/cache?p=s ... 1&.intl=us

Creams or lotions would be the ideal routes to administer antiandrogens. Their effect would be solely at the hair follicle, and indeed, only the areas of skin where unwanted hair was growing. Systemic side effects could be avoided, and the only conceivable problem would be an allergic dermatitis. Unfortunately, trials have been done with progesterone and spironolactone with no benefit. Recently the FDA approved Vaniqa (eflornithine hydrochloride) Cream for the treatment of hirsutism. This fragrance-free medication is applied similar to a moisturizing cream twice a day. Vaniqa works by actively inhibiting 5, alpha-reductase located in the root of the hair follicle, which is responsible for hair growth.

I don't know if we should rely too much on these "trials". They were for a VERY short period of time (i.e., around 3 months). However, it is bad news that spironolactone. cream doesn't appear to help women.

Btw, I read about Vaniqa a long time ago but don't know how it would work for us. Just never followed up on it because it.... well, I really don't know what to make of it. Maybe I should do more reading.

 

[Dave001]

Haven't been able to find the whole study, however, I did find a medical site that stated cream spironolactone. has not been shown to be effective for hirsutism when applied topically. Seems to be an acknowledged fact among professionals.

I'm well aware of the trials of spironolactone for hirsutism. I wanted to know the source of the abstract that you posted, because I couldn't find it in MEDLINE's index. Where did you find the abstract that you posted earlier in this thread? Do you have a link?

Btw, I read about Vaniqa a long time ago but don't know how it would work for us. Just never followed up on it because it.... well, I really don't know what to make of it. Maybe I should do more reading.

That stuff doesn't work by an antiandrogenic mechanism. It would probably damage your hair follicles and cause hair loss if applied to the scalp. It certainly wouldn't help.

 

[Bryan]

That stuff doesn't work by an antiandrogenic mechanism. It would probably damage your hair follicles and cause hair loss if applied to the scalp. It certainly wouldn't help.

I agree. I don't think the doctor who made that claim about Vaniqa knows what she's talking about.

Bryan

 

[Old Baldy]

Dave: I don't know what abstract you're saying I posted. I tried to find the full published study for the abstract Sir Lag. posted.

(You know, our avatars are pretty close in appearance.)

 

[Old Baldy]

That stuff doesn't work by an antiandrogenic mechanism. It would probably damage your hair follicles and cause hair loss if applied to the scalp. It certainly wouldn't help.

I agree. I don't think the doctor who made that claim about Vaniqa knows what she's talking about.

Bryan

Good. I figured something was off base.

 

[mvpsoft]

are you still using spironolactone in minoxidil after being told the reaction between the two renders the mixture useless?

According to Dr. Lee:

When minoxidil and spironolactone are combined in the same base, they will chemically react within a few hours and degrade each other causing a particularly offensive odor and compromising the pharmacological effect of both compoments. Since this chemical reaction requires many hours, it does not happen if minoxidil and spironolactone are applied to the scalp at the same time from separate containers.

http://www.hairlosshelp.com/html/drleespiroreview.cfm

 

[Dave001]

Dave: I don't know what abstract you're saying I posted. I tried to find the full published study for the abstract Sir Lag. posted.

(You know, our avatars are pretty close in appearance.)

opsblush:

You're right. I had mistaken the other poster for you because of the avatars.

 

[Sir_LagaLot]

link to website

http://www.ijem.org/iranian/9/4.html