Spironolactone lotion 5%

[GSXR]

I was thinking of adding this to my regimen, does anyone else here use the stuff? What do you all think about it?

 

[Old Baldy]

I've use the 5 percent cream from Dr. Lee, (still have alot yet to use and I like it). It dries well and is cosmetically acceptable. I use alot of topicals but something is working. Been using spironolactone cream a couple of months now. I can apply it and go to work. I like that!

spironolactone is good stuff IMHO. Bryan's homemade recipe for creamed spironolactone is: 6, 100mg tablets of spironolactone. crushed into 20 ml of Dermovan. I use unscented neutral creams like Cetaphil (or Neutrogena) and it mixes well and goes on fine. Bryan will have to tell you if Dermovan is better.

Note: Bryan's recipe is a 3 percent mix but that's enough from all I've read.

 

[viperfish]

I for one am not a big believer in spironolactone. I'm not saying that it does not work I just question its effectiveness. I think your much better going for eucapil than spironolactone. I'll tell you why; It is believed that spironolactone has a short half-life of somewhere near 3-4 hours (this is quoted from various websites). How they determined spironolactone's half-life in the scalp I can't say! However, based on this fact spironolactone would have to be applied every 4 hours or so to be really effective . Fluridil (eucapil) has shown to have 3x the affinity for attaching to the receptor sites than spironolactone and is also believed to have a longer half-life. I believe the half-life of fluridil has been quoted to be around 16 hours. Also look around and see how many posters report postive things with fluridil and not too many with spironolactone. I guess that kinda makes sense when you look at the potential of both drugs.

 

[The Gardener]

I use spironolactone 5, and I like it.

 

[Bryan]

I for one am not a big believer in spironolactone. I'm not saying that it does not work I just question its effectiveness. I think your much better going for eucapil than spironolactone. I'll tell you why; It is believed that spironolactone has a short half-life of somewhere near 3-4 hours (this is quoted from various websites). How they determined spironolactone's half-life in the scalp I can't say!

That has NEVER EVER been determined. That is sheer speculation on the part of those websites!

However, based on this fact spironolactone would have to be applied every 4 hours or so to be really effective .

There are successful animal studies with topical spironolactone in which it was applied only once a day, and not at all over weekends! Furthermore, the Italian study on topical spironolactone for male pattern baldness in humans had them apply it only twice a day. Despite all the buzz that's taken place on this issue, applying topical spironolactone only once or twice a day is clearly sufficient to produce a significant antiandrogenic response.

Fluridil (eucapil) has shown to have 3x the affinity for attaching to the receptor sites than spironolactone...

Viper, do you have a reference or citation for that claim?

Bryan

 

[Old Baldy]

There's no doubt that using spironolactone topical once a day reduces DHT for that day. It's a definite plus.

Oh I forgot to mention Viper, or "re-mention", spironolactone cream is cosmetically acceptable. That's important if we're to use it regularly.

 

[Fallout Boy]

Is Eucipal not cosmetically exceptable?

And Bryan, do you think Fluridil has greater or atleast equal effectiveness of spironolactone?

 

[Old Baldy]

Fluridil is applied before bedtime.

 

[everlastinggaze]

I used 5% spironolactone for over 11 months and didn't think it was working so I quit and got a real bad shed over the coarse of a couple months. I started using it again last month, so my fingers are crossed.

 

[Fallout Boy]

Fluridil is applied before bedtime.

but if i go out at night alot to parties, just drinking is it ok to apply in the mornings?? or does it have that greasy effect i hear people talking about??

 

[viperfish]

Fluridil is totally undetectable when applied to the scalp.


I really don't think that applying spironolactone once per day is enough to halt dht for the entire day. However, maybe enough for you to gain a positive benefit from it. Even if it is "speculation" that spironolactone's half life is 3-4 hours I think that is probably a "good" estimate. Don't you agree?


Bryan,
Do you still use spironolactone? If not, why not? I'm not trying to be a jerk here........ just wondering! If it is such a "potentially" great treatment, why not continue to use it?


I know, know, know, that reading other poster's postings does not mean much, but look around and tell me how many have benefited from using spironolactone in comparison to what you hear about flu. I go on that too and not just what the studies show. It is hard not to do that I guess.

 

[Old Baldy]

Fluridil is totally undetectable when applied to the scalp.


I really don't think that applying spironolactone once per day is enough to halt dht for the entire day. However, maybe enough for you to gain a positive benefit from it. Even if it is "speculation" that spironolactone's half life is 3-4 hours I think that is probably a "good" estimate. Don't you agree?


Bryan,
Do you still use spironolactone? If not, why not? I'm not trying to be a jerk here........ just wondering! If it is such a "potentially" great treatment, why not continue to use it?


I know, know, know, that reading other poster's postings does not mean much, but look around and tell me how many have benefited from using spironolactone in comparison to what you hear about flu. I go on that too and not just what the studies show. It is hard not to do that I guess.

Yes, even though I can't find what the half-life for spironolactone on the scalp is.

As to fluridil, I haven't used it. Sounds like good stuff, I didn't know how it worked cosmetically. Assumed it wasn't great cosmetically because the manufacturer suggests it be used at bedtime.

 

[Bryan]

I really don't think that applying spironolactone once per day is enough to halt dht for the entire day. However, maybe enough for you to gain a positive benefit from it. Even if it is "speculation" that spironolactone's half life is 3-4 hours I think that is probably a "good" estimate. Don't you agree?

I'm not sure...

Bryan,
Do you still use spironolactone? If not, why not? I'm not trying to be a jerk here........ just wondering! If it is such a "potentially" great treatment, why not continue to use it?

I use topical spironolactone.

Bryan