spironolactone effectiveness

[Johnny24601]

I have searched and reviewed posts on this site concerning sprio effectiveness and evidence is very inconclusive. I am having a hard time dealing with finasteride sides and have had to drop dosage drastically, so I need to add some topicals.
Any thoughts on spironolactone effectiveness would be helpful. I already know why is "should" work but there are serious questions in regards to its ability to dissolve into the scalp and whether a drug such as spironolactone could ever be helpful as a lotion and not in pill form. The only study I found was weak. I am especially interested in those who are using only topicals. Any help would be much appreciated. Thanks.

 

[iamnaked]

It is reckoned to be helpful in pill form, it just has an unfortunate habit of making you grow tits!

The rub of it is that although DHT doesn't seem to fulfil any useful functions in grown male, testosterone certainly does, and with spironolactone acting on testosterone you'd likely experience too many side effects for it to be worthwhile.

It has been noted, however that unlike fluridil (a comparable testosterone blocker) systematic absorption is low with spironolactone. This can be taken as being a good and a bad thing. It is good because it means you won't experience any of the undesirable side effects associated with anti-androgens, but bad because it also has a low halflife in the areas it acts on.

People can't agree on the effectiveness on spironolactone, because practically no-one has been willing to try spironolactone alone as a treatment. Using it with a load of other stuff effectively means you can't conclude anything from a person's success or lack of it, because you can't prove any success isn't down to the rest of the regimen. There have been two studies which claimed improvement on spironolactone, which I am inclined to trust.

So spironolactone is something of a leap of faith. It almost certainly won't perform miracles for you overnight, but on the basis of the evidence in front of me, and its mega-cheapness (I make my own topical) I'm willing to give it the nod.

Hope that's helpful.

 

[Johnny24601]

re:

1.) Taking spironolactone pills to battle hairloss is absolutely insane in my opinion and I never wanted to give the impression that I was considering that option.
2.) Fluridil makers report no systematic absorption just like spriro?
3.) Seeing how I have been on this site for a while and have heard very little on Fluridil I am guessing it is not very effective. Is it really just spironolactone in a cute bottle?
4.) Where are the thoughts from the topical only guys on this site? It appears that many people on this site experience sides from finasteride (I am not saying this to debate the overall reported side effects as I do not care) so I wish there was more discussion about topical effectiveness.....thanks

 

[Guest]

Why is Oral spironolactone a bad idea? :shock:

I have read it is just a medication to get rid of liquid in body, nothing else.

 

[iamnaked]

Re: re:

2.) Fluridil makers report no systematic absorption just like spriro?

Apologies- getting my antiandrogens mixed up. I meant flutamide.

3.) Seeing how I have been on this site for a while and have heard very little on Fluridil I am guessing it is not very effective. Is it really just spironolactone
in a cute bottle?

This may be a case of treatment fatigue. Fluridil is relatively new, and pretty expensive. The same issues about spironolactone affect fluridil - I don't think many are using it on its own.

 

[iamnaked]

Why is Oral spironolactone a bad idea? :shock:

I have read it is just a medication to get rid of liquid in body, nothing else.

It wipes out your testosterone. No testosterone equals b**ch tits, I'm afraid.

 

[socks]

Why is Oral spironolactone a bad idea? :shock:

I have read it is just a medication to get rid of liquid in body, nothing else.

It wipes out your testosterone. No testosterone equals b**** tits, I'm afraid.

Not true I'm afraid

Spironolactone is a androgen receptor blocker. What this means is Spironolactone binds to the same androgen receptors that hormones such as testosterone and DHT bind to thus preventing DHT and testosterone from exerting its full influence on the given tissue. Now, by decreasing the effectiveness of DHT/Testosterone on say breast tissue you allow the estrogen (yes men produce estrogen) to exert a greater influence. Depending on your genetics this may tip the balance so-to-speak and result in gyno.

Spironolactone can reduce testosterone to a point but it certainly does not wipe it out

 

[iamnaked]

Perhaps I need to rephrase: To take it in amounts which would be useful in reducing your hairloss would be to invite b**ch tits.