Shiny scalp
- Thread starter ethan
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Brains Expel Hair
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In general it seems like the longer you have not had hair somewhere, the less likely it is that you will ever grow it back in that area. This is why most people recommend starting management the day you notice somethings happening.
OverMachoGrande
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The "shine" is caused by excess sebum caused by enlarged sebaceous glands. Eating dairy directly contributes to sebum production because cows milk has DHT precursors and a powerful growth hormone called IGF-1 in it...plus it's loaded with artery clogging fat and cholesterol; raw material for making DHT and estrogen.
Sebum
The oil on the surface of skin is a complex mixture of sebum, lipids (from the surface skin cells), sweat and environmental material.
Sebum is produced by sebaceous glands. These are found over most of the body, although there are few on the hands or feet and none on the palms and soles. Sebaceous glands on the mid-back, forehead and chin are larger and more numerous than elsewhere (up to 400-900 glands per square centimetre). They are also numerous in the ear canal and around the genitals.
The sebaceous gland consists of lobes connected by ducts, which are lined with cells similar to those on the skin surface.
Most sebaceous glands open out into the hair follicle. Some free sebaceous glands open directly onto the skin surface. These include Meibomian glands on the eyelids, Tysons glands on the foreskin and Fordyce spots on the upper lip or genitals.
Sebum is produced when the sebaceous gland disintegrates. The cells take about a week from formation to discharge. Sebum is a complex and variable mixture of lipids including:
Glycerides
Free fatty acids
Wax esters
Squalene
Cholesterol esters
Cholesterol
Triglycerides produced by sebaceous glands are broken down by bacterial enzymes (lipases) in the sebaceous duct to form free fatty acids.
What does sebum normally do?
Sebum has the following functions:
It reduces water loss from the skin surface
It protects the skin from infection by bacteria and fungi
It contributes to body odour
It is colonised by the bacteria Proprionibacterium acnes, which may have a role in immune regulation
Hormonal control of sebum
Sebum production is under the control of sex hormones (androgens). The most active androgens are testosterone, 5-testosterone (DHT) and 5-androstene-317diol. These hormones and others are made by the sex glands (ovary in females, testis in males) and by the adrenal gland. These glands are in turn under the influence of the pituitary gland, located in the brain.
Androgens are made more active by enzymes in the skin and sexual organs. Type 1 5- reductase acts in the skin and Type II 5- reductase acts in the sexual organs. These enzymes convert less active androgens into the active testosterone and 5-testosterone (DHT). These more active androgens stimulate sebaceous gland cells to produce more sebum.
The role of progesterone is unclear. Females produce more sebum in the week before their menstrual period when progesterone levels are higher. But progesterone is known to reduce the activity of the enzyme 5-reductase that one might expect to reduce sebum production.
Sebum varies with age
Sebaceous glands are already active before birth. They are regulated by the mothers hormones and those made by the fetus itself.
The composition of oils on the skin surface varies with age. Excessive sebum production is known as seborrhoea.
The fetus produces vernix caseosa, a waxy protective layer
For 3 to 6 months, sebum produced by a newborn baby resembles that of an adult
Thereafter until the age of 8 it has less wax and squalene and more cholesterol
Sebum production increases at puberty up to fivefold in men
Adult males produce slightly more sebum than adult females
Sebum production declines with age, particularly after menopause in females
The amount of sebum can be altered by disease:
Pituitary, adrenal, ovarian or testicular disorders may increase or reduce it
Prolonged starvation reduces the amount of sebum
Parkinson's disease increases the amount of sebum
The amount can be reduced by certain systemic medications:
Oestrogens (oral contraceptive pill)
Antiandrogens such as cyproterone acetate and spironolactone
Vitamin-A derivatives such as isotretinoin
The amount can be increased by other systemic medications:
Testosterone given to prepubertal males
Progesterones with androgenic properties such as medroxyprogesterone, levonorgestrel
Phenothiazines
The proportion of different components may change with certain medications:
Diane-35® / Estelle-35®,containing ethinyl (o)estradiol 35mcg and cyproterone 2mg, increases linoleate
Isotretinoin reduces squalene, wax esters and fatty esters
The oil on the surface of skin is a complex mixture of sebum, lipids (from the surface skin cells), sweat and environmental material.
Sebum is produced by sebaceous glands. These are found over most of the body, although there are few on the hands or feet and none on the palms and soles. Sebaceous glands on the mid-back, forehead and chin are larger and more numerous than elsewhere (up to 400-900 glands per square centimetre). They are also numerous in the ear canal and around the genitals.
The sebaceous gland consists of lobes connected by ducts, which are lined with cells similar to those on the skin surface.
Most sebaceous glands open out into the hair follicle. Some free sebaceous glands open directly onto the skin surface. These include Meibomian glands on the eyelids, Tysons glands on the foreskin and Fordyce spots on the upper lip or genitals.
Sebum is produced when the sebaceous gland disintegrates. The cells take about a week from formation to discharge. Sebum is a complex and variable mixture of lipids including:
Glycerides
Free fatty acids
Wax esters
Squalene
Cholesterol esters
Cholesterol
Triglycerides produced by sebaceous glands are broken down by bacterial enzymes (lipases) in the sebaceous duct to form free fatty acids.
What does sebum normally do?
Sebum has the following functions:
It reduces water loss from the skin surface
It protects the skin from infection by bacteria and fungi
It contributes to body odour
It is colonised by the bacteria Proprionibacterium acnes, which may have a role in immune regulation
Hormonal control of sebum
Sebum production is under the control of sex hormones (androgens). The most active androgens are testosterone, 5-testosterone (DHT) and 5-androstene-317diol. These hormones and others are made by the sex glands (ovary in females, testis in males) and by the adrenal gland. These glands are in turn under the influence of the pituitary gland, located in the brain.
Androgens are made more active by enzymes in the skin and sexual organs. Type 1 5- reductase acts in the skin and Type II 5- reductase acts in the sexual organs. These enzymes convert less active androgens into the active testosterone and 5-testosterone (DHT). These more active androgens stimulate sebaceous gland cells to produce more sebum.
The role of progesterone is unclear. Females produce more sebum in the week before their menstrual period when progesterone levels are higher. But progesterone is known to reduce the activity of the enzyme 5-reductase that one might expect to reduce sebum production.
Sebum varies with age
Sebaceous glands are already active before birth. They are regulated by the mothers hormones and those made by the fetus itself.
The composition of oils on the skin surface varies with age. Excessive sebum production is known as seborrhoea.
The fetus produces vernix caseosa, a waxy protective layer
For 3 to 6 months, sebum produced by a newborn baby resembles that of an adult
Thereafter until the age of 8 it has less wax and squalene and more cholesterol
Sebum production increases at puberty up to fivefold in men
Adult males produce slightly more sebum than adult females
Sebum production declines with age, particularly after menopause in females
The amount of sebum can be altered by disease:
Pituitary, adrenal, ovarian or testicular disorders may increase or reduce it
Prolonged starvation reduces the amount of sebum
Parkinson's disease increases the amount of sebum
The amount can be reduced by certain systemic medications:
Oestrogens (oral contraceptive pill)
Antiandrogens such as cyproterone acetate and spironolactone
Vitamin-A derivatives such as isotretinoin
The amount can be increased by other systemic medications:
Testosterone given to prepubertal males
Progesterones with androgenic properties such as medroxyprogesterone, levonorgestrel
Phenothiazines
The proportion of different components may change with certain medications:
Diane-35® / Estelle-35®,containing ethinyl (o)estradiol 35mcg and cyproterone 2mg, increases linoleate
Isotretinoin reduces squalene, wax esters and fatty esters
Hoppi
Senior Member
- Reaction score
- 61
Am I right in saying that eventually the hair follicles actually die? 
So like, if the scalp is actually shiny and there are no signs of little hairs... could the follicles be actually GONE... or are they just still dormant?
There might be hope if you cut down sebum, lower overall and scalp DHT and give the hair follicles a little boost
So like, if the scalp is actually shiny and there are no signs of little hairs... could the follicles be actually GONE... or are they just still dormant?
There might be hope if you cut down sebum, lower overall and scalp DHT and give the hair follicles a little boost
Hoppi
Senior Member
- Reaction score
- 61
dougfunny said:
Well, from what I've heard it also often implies that the hair follicles have large sebaceous glands, which apparently can be bad as it accumulates 5ar and DHT. There is pretty reasonable evidence from what I've seen and heard that this impacts hair loss, hence why I've incorporated Coenzyme A into my regimen
hell at the very least I'll have a wicked complexion! lol
- Reaction score
- 43
raj47 said:
Not to any measurable extent. Kligman has done actual physical experiments showing that if you take areas of the skin with the highest sebum production (like the face and scalp) and multiply that level of sebum by 10 (literally apply TEN TIMES as much sebum as what normally occurs on the face), only then do you START to get a modest amount of water retention from that sebum. So sebum as it normally occurs on the body (even the face!) has no significant or measurable effect at all on water loss.
raj47 said:
Not according to Kligman. He has written extensively about that claim, and says sebum isn't antibacterial or fungistatic.
hey man bryan i been waiting long time to someone quote on the water and fungi ,
i was actually weird about that statement like water loss prevent and protect from fungi and bacteria .thanks
couple of question for you .
experiment says that it will prevent water loss how can it will prevent?
my thought is this :
1.as we look into physics if you put one tea spoon of oil into a bowl of water it will remain at top its because of its density .the same thing it will happen your head so sebum will on the top it will block the oxygen so there no room to breathe for follicles .
2.take same concept and heat the oil and water ,water will quickly evaporate compare to oil.hence there is no water.and oil will remain in the area.
3.compare to water and oil ,oil will easily attract impurities and dust from the air easily so there is a room for bacteria and fungi to grow.
i was actually weird about that statement like water loss prevent and protect from fungi and bacteria .thanks
couple of question for you .
experiment says that it will prevent water loss how can it will prevent?
my thought is this :
1.as we look into physics if you put one tea spoon of oil into a bowl of water it will remain at top its because of its density .the same thing it will happen your head so sebum will on the top it will block the oxygen so there no room to breathe for follicles .
2.take same concept and heat the oil and water ,water will quickly evaporate compare to oil.hence there is no water.and oil will remain in the area.
3.compare to water and oil ,oil will easily attract impurities and dust from the air easily so there is a room for bacteria and fungi to grow.
Exp Dermatol. 2008 Jun;17(6):542-51.
Frontiers in sebaceous gland biology and pathology.
Zouboulis CC, Baron JM, Böhm M, Kippenberger S, Kurzen H, Reichrath J, Thielitz A.
Department of Dermatology, Dessau Medical Center, Dessau, Germany. christos.zouboulis@klinikum-dessau.de
The development of experimental models for the in vitro study of human sebaceous gland turned down the theory of a phylogenetic relict and led to the identification of several, unknown or disregarded functions of this organ. Such functions are the production of foetal vernix caseosa, the influence of three-dimensional organization of the skin surface lipids and the integrity of skin barrier and the influence on follicular differentiation. In addition, the sebaceous gland contributes to the transport of fat-soluble antioxidants from and to the skin surface, the natural photoprotection, the pro- and antiinflammatory skin properties and to the innate antimicrobial activity of the skin. It is mainly responsible for skin's independent endocrine function, the hormonally induced skin ageing process, the steroidogenic function of the skin as well as its thermoregulatory and repelling properties and for selective control of the hormonal and xenobiotical actions of the skin. Interestingly, sebocytes, at least in vitro, preserve characteristics of stem-like cells despite their programming for terminal differentiation. This review reports on various sebaceous gland functions, which are currently under investigation, including its role on the hypothalamus-pituitary-adrenal-like axis of the skin, the impact of acetylcholine on sebocyte biology, the activity of ectopeptidases as new targets to regulate sebocyte function, the effects of vitamin D on human sebocytes, the expression of retinoid metabolizing cytochrome P450 enzymes and the possible role of sebum as vehicle of fragrances. These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland.
PMID: 18474083 [PubMed - indexed for MEDLINE]
and more ......
http://www.jlr.org/cgi/content/full/49/2/271
There is more beyond Kligmang`s studies (good investigations otoh)
Armando
Frontiers in sebaceous gland biology and pathology.
Zouboulis CC, Baron JM, Böhm M, Kippenberger S, Kurzen H, Reichrath J, Thielitz A.
Department of Dermatology, Dessau Medical Center, Dessau, Germany. christos.zouboulis@klinikum-dessau.de
The development of experimental models for the in vitro study of human sebaceous gland turned down the theory of a phylogenetic relict and led to the identification of several, unknown or disregarded functions of this organ. Such functions are the production of foetal vernix caseosa, the influence of three-dimensional organization of the skin surface lipids and the integrity of skin barrier and the influence on follicular differentiation. In addition, the sebaceous gland contributes to the transport of fat-soluble antioxidants from and to the skin surface, the natural photoprotection, the pro- and antiinflammatory skin properties and to the innate antimicrobial activity of the skin. It is mainly responsible for skin's independent endocrine function, the hormonally induced skin ageing process, the steroidogenic function of the skin as well as its thermoregulatory and repelling properties and for selective control of the hormonal and xenobiotical actions of the skin. Interestingly, sebocytes, at least in vitro, preserve characteristics of stem-like cells despite their programming for terminal differentiation. This review reports on various sebaceous gland functions, which are currently under investigation, including its role on the hypothalamus-pituitary-adrenal-like axis of the skin, the impact of acetylcholine on sebocyte biology, the activity of ectopeptidases as new targets to regulate sebocyte function, the effects of vitamin D on human sebocytes, the expression of retinoid metabolizing cytochrome P450 enzymes and the possible role of sebum as vehicle of fragrances. These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland.
PMID: 18474083 [PubMed - indexed for MEDLINE]
and more ......
http://www.jlr.org/cgi/content/full/49/2/271
There is more beyond Kligmang`s studies (good investigations otoh)
Armando
dougfunny
Established Member
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Hoppi said:dougfunny said:
Well, from what I've heard it also often implies that the hair follicles have large sebaceous glands, which apparently can be bad as it accumulates 5ar and DHT. There is pretty reasonable evidence from what I've seen and heard that this impacts hair loss, hence why I've incorporated Coenzyme A into my regimen
hell at the very least I'll have a wicked complexion! lol
have you tried b5 yet? if you did did it dry out your skin? i'm thinking of taking it, though just do have dry skin not to regrow hair...
Hoppi
Senior Member
- Reaction score
- 61
dougfunny said:Hoppi said:dougfunny said:
Well, from what I've heard it also often implies that the hair follicles have large sebaceous glands, which apparently can be bad as it accumulates 5ar and DHT. There is pretty reasonable evidence from what I've seen and heard that this impacts hair loss, hence why I've incorporated Coenzyme A into my regimen
hell at the very least I'll have a wicked complexion! lol
have you tried b5 yet? if you did did it dry out your skin? i'm thinking of taking it, though just do have dry skin not to regrow hair...
erm, I am yeah.. no huge changes, nothing I've really noticed. I am looking forward to seeing any changes while on CoA though because that should clear the little spots on some small areas of my face and neck, but most importantly the little ones I sometimes get where my hair is receding. They look a bit suspect to me! I'm pretty sure they're just normal spots, but I'd be happier rid of them!
I'll keep you posted!