Serum Paroxonase 1 level may be an Indicator and Predictor of the Severity of Androgenetic Alopecia

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Androgenetic Alopecia is a PON1 gene Polymorphism?

Association SOD2 and PON1 Gene Polymorphisms with Polycystic Ovary Syndrome in Saudi Women

Abstract. Polycystic ovary syndrome (PCOS) is a considered one of the most common female disorders associated with reproductive, metabolic, and psychological problems. The etiology of PCOS is still not yet disclosed; however, evidence for a genetic basis has been reported. In this study, we...

www.karger.com

 

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Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.​

Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on

Paraoxonase 1 (PON1) is a high density lipoprotein (HDL)-associated enzyme displaying esterase and lactonase activity. PON1 hydrolyzes several organophosphorus (OP) insecticides and nerve agents, a number of exogenous and endogenous lactones, and metabolizes ...

www.ncbi.nlm.nih.gov

Table 1​

Pharmaceutical drugs found to increase PON1 activity/expression in animals or Humans

Drugs​	PON1 increase​	Reference​
Cardiovascular drugs​
Statins (simvastatin, atorvastatin)*​	5–23%​	[17–20, 25]​
Fibrates (Gemfibrozil, fenofibrate)*​	18–59%​	[23, 29]​
Probucol​	50%​	[36]​
Ezetimibe​	32%​	[37]​
Aspirin*​	13%​	[32, 34]​
Antidiabetic drugs​
Rosiglitazone​	10–67%​	[38–40]​
Eplerenone​	60%​	[41]​
Sulphonylureas (glimepiride, glibenclamide)​	28–64%**​	[42]​
Other drugs​
Erythropoietin beta​	23%​	[48]​

Table 2​

Dietary antioxidants found to increase PON1 activity/expression in animals or Humans

Antioxidant​	PON1 increase​	Reference​
Vitamin C, Vitamin E​	7–80%​	[55–59]​
Quercetin​	30–200%​	[62–66]​
Green tea​	17–40%​	[70]​
Grape seed extract​	21–87%​	[72]​
Blueberries​	25%​	[73]​
Pomegranate juice​	20–80%​	[75–77]​
Dates (Hallawi variety)​	15%​	[80]​
Protandim®​	35%​	[74]​

 

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PON1: Increase Longevity And Detox Pesticides with 99+ Ways To Increase Paraoxonase 1 — MyBioHack | Unlock Your Genetics

Paraoxonase 1 (PON1) is an enzyme that plays a role in most diseases. In this post, we will discuss how you can use PON1 to improve overall health, longevity, and detox mechanisms.

mybiohack.com

PON1 Detox Pesticides Inflammation & Antioxidant - SelfHack

Low PON1 could be behind your oxidative stress, problems with detoxifying & bacterial infections. Learn how to decrease inflammation by increasing PON1.

selfhack.com

 

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People have taken tocopherols & tocotrienols, glutathione, NAC, astaxanthin and many other antioxidants without success.

What I love about studies like these though is that it throws a wrench in the broscience argument that balding men are the same as everyone else, but they just somehow miraculously have "DHT-sensitive folllicles". Systemic differences prove that whatever is causing Androgenetic Alopecia is present over the entire body, the hair follicle likely just manifests it the strongest.

EDIT: Apparently it's not just a mild difference either. Non balding people have 3 times as much PON1 on average.

View attachment 174751

It seems that the general consensus is a decrease of serum PON1 enzyme activities is directly associated with systematic oxidative stress and chronic inflammation. Same conclusion on every papers/studies.

example below.. I can carry on forever with so many studies.

"Genetic deletion of PON1 is associated with increased susceptibility of LDL to oxidation ex vivo, increased measures of macrophage oxidative stress, and increased lesion size in animal models of atherosclerosis; conversely, overexpression of the human PON1 transgene in mice results in reduced aortic lesion size and corresponding decreases in epitopes recognized by antibodies specific for oxidized lipid-protein adducts"

 

[FilthyFrancis]

Anybody on high dose quercetin/genistein supplementation? Doubt it'd make a difference but shouldn't hurt

 

[inmyhead]

I started on Pomegranate extract on the basis of increasing paroxonase and progesterone. Apparently it's not a simple matter whether Pomegranate is estrogenic. It reduces estradiol and acts as a SERM, and in women reduces both Estrone and Testosterone. If it were estrogenic though, I don't know why people use it for ED. I keep seeing 'hormone balancing'.

Anyway, I will also be starting Alfatradiol too soon.

I haven't been taking anything recently so will be able to report any progress or lack thereof.

are you still on it?

 

[zaman]

are you still on it?

Not consistently. I lost interest a bit because I expected some sort of changes to take place in 4 months but didn't notice anything. I know that's a short time frame, but I expect to see at least something, or reduction in shedding. To be fair, I also have concerns about my liver so was recently alternating with other vitamins and having days off

Still using Alfatradiol though.