Serum DHT vs Scalp DHT

[peloncete1989]

Hi people,

I was wondering which is the difference between "scalp DHT" and "serum DHT".

I guess "scalp DHT" needs "serum DHT" concentration to reach the scalp; am I right?

Then, what means in the dutasteride/finasteride studies the differenciation of "scalp DHT" and "serum DHT"?

I know Avidart inhibits, 90% of serum DHT and 55% of scalp DHT, what it mean?

The 55% is inhibited from the total DHT or from the 10% (respect the 90% serum inhibit)?

Thankyou.

 

[Bryan]

I guess "scalp DHT" needs "serum DHT" concentration to reach the scalp; am I right?

DHT molecules are formed inside hair follicle cells themselves, so they don't "need" blood serum to be carried or transported anywhere.

 

[armandein]

I know Avidart inhibits, 90% of serum DHT and 55% of scalp DHT, what it mean?

If DHT is formed inside cells, then Avidart reach more difficult to hair cells?

 

[peloncete1989]

1) So, serum DHT is important for us or not?

2) Avoiding the DHT conversion at "blood" (serum), we are "carrying" more T to the scalp that will be converted in DHT?

 

[Bryan]

1) So, serum DHT is important for us or not?

I think it's pretty clear that DHT generated inside hair follicles is considerably more important than DHT that gets to hair follicles by way of the bloodstream.

2) Avoiding the DHT conversion at "blood" (serum), we are "carrying" more T to the scalp that will be converted in DHT?

We're carrying testosterone to hair follicles, which then gets converted to DHT in the hair follicle.

 

[peloncete1989]

1) So, serum DHT is important for us or not?

I think it's pretty clear that DHT generated inside hair follicles is considerably more important than DHT that gets to hair follicles by way of the bloodstream.

2) Avoiding the DHT conversion at "blood" (serum), we are "carrying" more T to the scalp that will be converted in DHT?

We're carrying testosterone to hair follicles, which then gets converted to DHT in the hair follicle.

So, reducing serum-DHT (whic means more serum-T) could be, even, worse... am I right?

 

[Bryan]

So, reducing serum-DHT (whic means more serum-T) could be, even, worse... am I right?

No. DHT is a much stronger androgen than testosterone, so reducing it (DHT) is always more effective in the fight against male pattern baldness, even if testosterone rises a bit in response.

 

[peloncete1989]

Now I get it.

Thanks man. Really appreciate it.