This study decribe pros and cons of bmp pathway http://onlinelibrary.wiley.com/store/10.1634/stemcells.2005-0544/asset/242826_ftp.pdf;jsessionid=749EAE04D89E5CC75606749EB9AF7731.f04t02?v=1&t=ix5wjcft&s=8baa793bb7395b69d3f4d6f71cafc41fd12d78f3