Seeming balding contradictions

[blaze]

What is the exact reason as to why people suffer from Androgenetic Alopecia(male pattern baldness)?

I have read some say that it is because people predisposed to Androgenetic Alopecia have androgen receptors on their follicles, whereas people who arent dont.

Then I have read, everyone has androgen receptors on their follicles, its just people with Androgenetic Alopecia have hair that is sensitive to DHT and therefore is damaged when it attaches to the follicle.

Then I have read that it is just merely an excess of DHT in the scalp of those who will suffer from Androgenetic Alopecia that causes it. People who dont have Androgenetic Alopecia dont have this "excess" DHT roaming in their scalp.

I know genetics is always involved, but as far as the rest which is it?? :?

 

[everysixseconds]

well, my two pence worth:

male pattern baldness only affect people which are genetically pre-disposed to the following series of events.

androgen receptors on the hair follicle bind DHT, immue system recognises the hair follicle-DHT complex as somehow alien and attacks the follicle to death. tahts why immuno-suppresants are great for making hair grow. although, my eating them its like voluntarily giving yourself AIDS. see why its not such a good idea?

in non-male pattern baldness people the dht may not bind to hair follicles as they may lack androgen receptors.. dunno about those freaks of nature!! lol!

 

[Bryan]

All human scalp hair follicles contain androgen receptors (BTW, androgen receptors are proteins found within the cellular cytoplasm).

People with balding do tend to have somewhat higher average levels of DHT and other androgens and steroidogenic enzymes, but I suspect that the main problem is that they also have a worse RESPONSE to androgens than non-balding people. In other words, androgens in general alter the production of various growth factors within hair follicles, and that alteration is WORSE (more on the NEGATIVE side) in balding people than it is in non-balding people.

Bryan

 

[Armando Jose]

Hi;

The current theory don't hold water very well. How is it possible explain the developing of bald areas in predisposed people years after the contact with androgens?, also can explain the dinamic pattern modeling: receding line front and from the crown to outside?

In my oppinion there is anything (in my theory problems with the sebum replacement and drainage) before the decisive influence of DHT.

Regards
Armando