sebaceous gland is not a relic in scalp hairs Kligman

[docj077]

The skin peeling and sun sensitivity from Accutane has nothing to do with its sebum reduction.

HA?
SEBUM hidrates the skin and while taking accutane your lips scalp and face all become dry, how can this not be an affect of sebum?

First of all, sebum doesn't have any significant role in hydrating the skin.

Second of all, young children and people with Complete Androgen Insensitivity Syndrome probably produce even less sebum than patients taking Accutane, and yet THEY don't have permanently dry skin, scaling, peeling, etc. I don't believe doctors know yet exactly how Accutane works, but it obviously has other very significant effects on the structure and the function of the skin, besides just a simple reduction in sebum production.

Bryan

Doesn't accutane increase keratinocyte production and turnover? Just off-hand without looking anything up that sounds right to me. If so, that's your explanation. Increased turnover is going to give you dry flakey skin. Accutane is like instant psoriasis in a pill.